SmProt

Specific Information of Small Protein : SPROHSA214299

General Information

Small Protein ID	SPROHSA214299
Organism	Human (Homo sapiens)
Small Protein Sequence	MSAFVPEVSMQSSGYLDECQLLHFPCVSCDHSIWEHPSKSSCILLRTPDLLKLHNSHLDVTGLSHVNSSDHVLLYMPSAPSQDSYKRRNDEHP*
RNA Sequence	ATGTCAGCATTTGTACCTGAAGTCAGCATGCAAAGTTCAGGGTACCTGGATGAATGCCAACTTTTGCATTTCCCATGTGTATCCTGTGACCATTCTATCTGGGAACATCCTTCAAAGAGTTCATGCATCTTACTGAGGACACCTGACCTTTTGAAGCTTCATAATTCACATCTAGATGTCACCGGTCTTTCCCATGTTAACAGTTCTGACCATGTTTTATTATATATGCCTTCGGCGCCGAGCCAGGACAGCTACAAGAGGAGAAATGATGAACACCCATAG
Protein Length	93
Start Codon	ATG
Location	chr6:98926881-98927807:-
Blocks	98926881-98927060,98927704-98927807
Mean PhyloCSF	-4.66791134439
Data Source	Ribosome profiling; Literature;
Related Genes	ENSG00000112234; FBXL4; NONHSAG044429;
Mass (Da)	mono. 10497; avg. 10503.7

Ribosome profiling

Ribo-seq ID	Ensembl Gene ID	Ensembl Transcript ID	Symbol	Gene Type	TIS Type	Ribo P value	TIS P value	Start On Trans	Stop On Trans	In-frame Count	Ribo-seq RPKM
SRR4045276	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	6.368E-07	None	216	498	38	31.9147516
SRR4045276_alt	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	6.368E-07	None	216	498	38	31.9147516
SRR3208921	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.032657	None	216	498	6	4.72945243
SRR3208921_alt	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.032657	None	216	498	6	4.72945243
SRR5047772	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.002411	None	216	498	64	40.1300062
SRR5047771	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	1.349E-08	None	216	498	172	27.8934012
SRR5047770_alt	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	6.773E-10	None	216	498	101	28.4161688
SRR5047770	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	6.773E-10	None	216	498	101	28.4161688
GSE94613_2	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.023481	None	216	498	17	12.5440696
SRR2991181	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.030491	None	216	498	19	11.0124391
SRR2991181_alt	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.030491	None	216	498	19	11.0124391
SRR618770,618771,618772,618773_alt	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	1.38E-05	6.304E-05	216	498	77	46.0955313
SRR4045276	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	6.368E-07	None	274	556	38	31.9147516
SRR4045276_alt	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	6.368E-07	None	274	556	38	31.9147516
SRR3208921	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	0.032657	None	274	556	6	4.72945243
SRR3208921_alt	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	0.032657	None	274	556	6	4.72945243
SRR5047772	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	0.002411	None	274	556	64	40.1300062
SRR5047771	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	1.349E-08	None	274	556	172	27.8934012
SRR5047770_alt	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	6.773E-10	None	274	556	101	28.4161688
SRR5047770	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	6.773E-10	None	274	556	101	28.4161688
SRR2991181	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	0.030491	None	274	556	19	11.0124391
SRR2991181_alt	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	0.030491	None	274	556	19	11.0124391
SRR618770,618771,618772,618773_alt	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	1.38E-05	6.304E-05	274	556	77	46.0955313

Min Ribo P value	6.773E-10
Min TIS P value	6.304E-05

Ribo-seq ID	Cell or Tissue	Phenotype	Ribo-seq Source Details	PMID
GSE94613_2	MOLM13	Acute myeloid leukemia	GSM2481053	29186125;
SRR2991181	SH-SY5Y	Neuroblastoma	GSM1970518	31109297;
SRR2991181_alt	SH-SY5Y	Neuroblastoma	GSM1970518	31109297;
SRR3208921	ES cell-derived neurons TSC2-/-	Tuberous sclerosis complex	GSM2082573	27655340;
SRR3208921_alt	ES cell-derived neurons TSC2-/-	Tuberous sclerosis complex	GSM2082573	27655340;
SRR4045276	Meg01 cells	WT	GSM2285909	27681415;
SRR4045276_alt	Meg01 cells	WT	GSM2285909	27681415;
SRR5047770	iPSC-differentiated dopamine neurons	Parkinson Disease	GSM2402496; GSM2402497; GSM2402498	NA;
SRR5047770_alt	iPSC-differentiated dopamine neurons	Parkinson Disease	GSM2402496; GSM2402497; GSM2402498	NA;
SRR5047771	iPSC-differentiated dopamine neurons	Parkinson Disease	NA	NA;
SRR5047772	iPSC-differentiated dopamine neurons	Parkinson Disease	NA	NA;
SRR618770,618771,618772,618773_alt	HEK293	WT	SRR618770; SRR618771; SRR618772; SRR618773	NA;

Database information

No results

Literature information

PMID	26687005;
Cell lines Or Tissues	BJ
Phenotype	NULL
Gene ID	ENSG00000112234
Transcript ID	ENST00000369244
Symbol	FBXL4
ORF Type	sORF
Gene Type	protein_coding
Throughput	High-throughput Literature Mining
Interaction	NA
Function Description	NA

Mass Spectrometry Information

No results

Function and Disease

Functional domain prediction

Analysis	Signature Accession	Signature Description	Start location	Stop location	Score	Status of the match	InterPro accession	InterPro description	GO	Pathways
No results

Disease	Detected
No results

Related Variants

Variant ID	Consequence to sORF	rsID	Ribo-seq ID
6-98926884-A-T	Stop Loss p.*94K	rs34316889	SRR627627
6-98927762-G-T	Non-Synonymous p.L16M	rs195812	SRR5047770; SRR5047771; SRR5047772; SRR5350744; SRR1333393; SRR1333394; SRR1795425; SRR1795427; SRR1795428; SRR618771

Related Small Proteins with Different TISs

SmProt ID	Small Protein Length	Start Codon	Strand	Blocks
SPROHSA10890	8	AAG	-	98926881-98926908
SPROHSA170821	18	ATG	-	98926881-98926938
SPROHSA23712	42	AAG	-	98926881-98927010
SPROHSA66042	48	AGG	-	98926881-98927028
SPROHSA259355	49	CTG	-	98926881-98927031
SPROHSA134529	51	ATC	-	98926881-98927037
SPROHSA374324	72	TTG	-	98926881-98927060, 98927704-98927744
SPROHSA290599	78	CTG	-	98926881-98927060, 98927704-98927762
SPROHSA160770	84	ATG	-	98926881-98927060, 98927704-98927780

a reliable repository with comprehensive annotation of small proteins derived from ribosome profiling