SmProt

Specific Information of Small Protein : SPROHSA160770

General Information

Small Protein ID	SPROHSA160770
Organism	Human (Homo sapiens)
Small Protein Sequence	MQSSGYLDECQLLHFPCVSCDHSIWEHPSKSSCILLRTPDLLKLHNSHLDVTGLSHVNSSDHVLLYMPSAPSQDSYKRRNDEHP*
RNA Sequence	ATGCAAAGTTCAGGGTACCTGGATGAATGCCAACTTTTGCATTTCCCATGTGTATCCTGTGACCATTCTATCTGGGAACATCCTTCAAAGAGTTCATGCATCTTACTGAGGACACCTGACCTTTTGAAGCTTCATAATTCACATCTAGATGTCACCGGTCTTTCCCATGTTAACAGTTCTGACCATGTTTTATTATATATGCCTTCGGCGCCGAGCCAGGACAGCTACAAGAGGAGAAATGATGAACACCCATAG
Protein Length	84
Start Codon	ATG
Location	chr6:98926881-98927780:-
Blocks	98926881-98927060,98927704-98927780
Mean PhyloCSF	-4.39192549481
Data Source	Ribosome profiling;
Related Genes	ENSG00000112234; FBXL4; NONHSAG044429;
Mass (Da)	mono. 9549.5; avg. 9555.6

Ribosome profiling

Ribo-seq ID	Ensembl Gene ID	Ensembl Transcript ID	Symbol	Gene Type	TIS Type	Ribo P value	TIS P value	Start On Trans	Stop On Trans	In-frame Count	Ribo-seq RPKM
SRR5512738	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.032483	None	243	498	14	6.95986037
GSE45833_4	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.016684	None	243	498	8	6.77834558
GSE123564_1_alt	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.011768	None	243	498	6	4.69160766
GSE123564_1	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.011768	None	243	498	6	4.69160766
GSE103308	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.021511	None	243	498	38	13.2554897
GSE105082	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.000216	None	243	498	27	7.19521702
GSE94454	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	8.465E-06	None	243	498	45	7.85570953
GSE94454_alt	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	8.465E-06	None	243	498	45	7.85570953
GSE94613_1	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.038041	None	243	498	10	22.6527197
GSE94613_1_alt	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.038041	None	243	498	10	22.6527197
SRR7207252	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.000282	None	243	498	33	34.2234132
SRR7207252_alt	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.000282	None	243	498	33	34.2234132
GSE83493	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.011215	None	243	498	32	15.0388411
SRR5350745	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.036164	None	243	498	3	6.91711942
SRR5350745_alt	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	0.036164	None	243	498	3	6.91711942
SRR618770,618771,618772,618773_alt	ENSG00000112234.9	ENST00000229971.2	FBXL4	Protein_coding	5'UTR	8.622E-06	0.025107	243	498	67	44.3559444
SRR5512738	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	0.032483	None	301	556	14	6.95986037
GSE45833_4	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	0.016684	None	301	556	8	6.77834558
GSE123564_1_alt	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	0.011768	None	301	556	6	4.69160766
GSE123564_1	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	0.011768	None	301	556	6	4.69160766
GSE103308	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	0.021511	None	301	556	38	13.2554897
GSE105082	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	0.000216	None	301	556	27	7.19521702
GSE94454	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	8.465E-06	None	301	556	45	7.85570953
GSE94454_alt	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	8.465E-06	None	301	556	45	7.85570953
GSE94613_1	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	0.038041	None	301	556	10	22.6527197
GSE94613_1_alt	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	0.038041	None	301	556	10	22.6527197
SRR7207252	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	0.000282	None	301	556	33	34.2234132
SRR7207252_alt	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	0.000282	None	301	556	33	34.2234132
GSE83493	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	0.011215	None	301	556	32	15.0388411
SRR5350745	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	0.036164	None	301	556	3	6.91711942
SRR5350745_alt	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	0.036164	None	301	556	3	6.91711942
SRR618770,618771,618772,618773_alt	ENSG00000112234.9	ENST00000369244.7	FBXL4	Protein_coding	5'UTR	8.622E-06	0.025107	301	556	67	44.3559444

Min Ribo P value	8.465E-06
Min TIS P value	None

Ribo-seq ID	Cell or Tissue	Phenotype	Ribo-seq Source Details	PMID
GSE103308	RD-muscle	WT	GSM2760247	29696588;
GSE105082	HELA	Cervical cancer	GSM2817679; GSM2817680	30591072;
GSE123564_1	Skin fibroblasts	WT	GSM3507221; GSM3507222; GSM3507226; GSM3507227	30707697;
GSE123564_1_alt	Skin fibroblasts	WT	GSM3507221; GSM3507222; GSM3507226; GSM3507227	30707697;
GSE45833_4	BJ cells	Proliferation	GSM1047589	23594524;
GSE83493	HeLa S3	Cervical cancer	GSM2204389; GSM2204390; GSM2204391; GSM2204392	28460002;
GSE94454	Huh7	Hepatoma	GSM2476003; GSM2476004; GSM2476005	28323820;
GSE94454_alt	Huh7	Hepatoma	GSM2476003; GSM2476004; GSM2476005	28323820;
GSE94613_1	MOLM13	Acute myeloid leukemia	GSM2481052	29186125;
GSE94613_1_alt	MOLM13	Acute myeloid leukemia	GSM2481052	29186125;
SRR5350745	H1933	NSCLC	GSM2538904	28388414;
SRR5350745_alt	H1933	NSCLC	GSM2538904	28388414;
SRR5512738	GM19147-Lymphoblastoid Cell Line	WT	GSM2601312	29950183;
SRR618770,618771,618772,618773_alt	HEK293	WT	SRR618770; SRR618771; SRR618772; SRR618773	NA;
SRR7207252	MCF10A-ER-Src	Breast adenocarcinoma	GSM3150265	30089253;
SRR7207252_alt	MCF10A-ER-Src	Breast adenocarcinoma	GSM3150265	30089253;

Database information

No results

Literature information

No results

Mass Spectrometry Information

No results

Function and Disease

Functional domain prediction

Analysis	Signature Accession	Signature Description	Start location	Stop location	Score	Status of the match	InterPro accession	InterPro description	GO	Pathways
No results

Disease	Detected
No results

Related Variants

Variant ID	Consequence to sORF	rsID	Ribo-seq ID
6-98926884-A-T	Stop Loss p.*85K	rs34316889	SRR627627
6-98927762-G-T	Non-Synonymous p.L7M	rs195812	SRR5047770; SRR5047771; SRR5047772; SRR5350744; SRR1333393; SRR1333394; SRR1795425; SRR1795427; SRR1795428; SRR618771

Related Small Proteins with Different TISs

SmProt ID	Small Protein Length	Start Codon	Strand	Blocks
SPROHSA10890	8	AAG	-	98926881-98926908
SPROHSA170821	18	ATG	-	98926881-98926938
SPROHSA23712	42	AAG	-	98926881-98927010
SPROHSA66042	48	AGG	-	98926881-98927028
SPROHSA259355	49	CTG	-	98926881-98927031
SPROHSA134529	51	ATC	-	98926881-98927037
SPROHSA374324	72	TTG	-	98926881-98927060, 98927704-98927744
SPROHSA290599	78	CTG	-	98926881-98927060, 98927704-98927762
SPROHSA214299	93	ATG	-	98926881-98927060, 98927704-98927807

a reliable repository with comprehensive annotation of small proteins derived from ribosome profiling