SmProt

Specific Information of Small Protein : SPROHSA219922

General Information

Small Protein ID	SPROHSA219922
Organism	Human (Homo sapiens)
Small Protein Sequence	MWRSSARASVVMTVFALRGEGMCDHFQRLTCIPQIVWMSYNLNLQTQYSQTLGSDSLQASCTSPRKRACFPLDM*
RNA Sequence	ATGTGGCGCTCCTCGGCCCGCGCTTCAGTGGTTATGACAGTGTTCGCTCTAAGGGGAGAAGGAATGTGTGACCATTTCCAACGGTTAACTTGCATTCCCCAGATAGTTTGGATGAGTTACAACCTAAATCTGCAAACTCAATACAGCCAGACCCTGGGAAGTGACTCTCTCCAAGCCTCCTGTACAAGTCCCAGGAAAAGAGCCTGTTTTCCCTTGGACATGTGA
Protein Length	74
Start Codon	ATG
Location	chrX:46545544-46546607:+
Blocks	46545544-46545627,46546465-46546607
Mean PhyloCSF	-8.03997779846
Data Source	Ribosome profiling; Literature;
Related Genes	ENSG00000230844; ZNF674-AS1; NONHSAG054360;
Mass (Da)	mono. 8417; avg. 8422.7

Ribosome profiling

Ribo-seq ID	Ensembl Gene ID	Ensembl Transcript ID	Symbol	Gene Type	TIS Type	Ribo P value	TIS P value	Start On Trans	Stop On Trans	In-frame Count	Ribo-seq RPKM
SRR3208885	ENSG00000230844.3	ENST00000657382.1	ZNF674-AS1	LncRNA	Novel	0.042377	None	107	332	18	14.3728910
SRR3208885_alt	ENSG00000230844.3	ENST00000657382.1	ZNF674-AS1	LncRNA	Novel	0.042377	None	107	332	18	14.3728910
SRR4045276	ENSG00000230844.3	ENST00000657382.1	ZNF674-AS1	LncRNA	Novel	0.007171	None	107	332	7	7.36838828
SRR3317843	ENSG00000230844.3	ENST00000657382.1	ZNF674-AS1	LncRNA	Novel	0.007171	None	107	332	7	26.1817433
SRR3317843_alt	ENSG00000230844.3	ENST00000657382.1	ZNF674-AS1	LncRNA	Novel	0.007171	None	107	332	7	26.1817433
SRR3208921	ENSG00000230844.3	ENST00000657382.1	ZNF674-AS1	LncRNA	Novel	0.029214	None	107	332	22	21.7344613
SRR3208921_alt	ENSG00000230844.3	ENST00000657382.1	ZNF674-AS1	LncRNA	Novel	0.029214	None	107	332	22	21.7344613
GSE105082	ENSG00000230844.3	ENST00000657382.1	ZNF674-AS1	LncRNA	Novel	0.000279	None	107	332	34	10.2687294
GSE58207_alt	ENSG00000230844.3	ENST00000657382.1	ZNF674-AS1	LncRNA	Novel	0.000308	4.225E-05	107	332	43	19.6818675
SRR5047771	ENSG00000230844.3	ENST00000657382.1	ZNF674-AS1	LncRNA	Novel	4.875E-06	None	107	332	37	7.52040694
SRR5047772	ENSG00000230844.3	ENST00000657382.1	ZNF674-AS1	LncRNA	Novel	9.929E-05	None	107	332	24	18.8611029
SRR618770,618771,618772,618773_alt	ENSG00000230844.3	ENST00000657382.1	ZNF674-AS1	LncRNA	Novel	1.466E-05	6.304E-05	107	332	22	16.5065902
SRR3208885	ENSG00000230844.3	ENST00000421685.2	ZNF674-AS1	LncRNA	Novel	0.042377	None	52	277	18	14.3728910
SRR3208885_alt	ENSG00000230844.3	ENST00000421685.2	ZNF674-AS1	LncRNA	Novel	0.042377	None	52	277	18	14.3728910
SRR4045276	ENSG00000230844.3	ENST00000421685.2	ZNF674-AS1	LncRNA	Novel	0.007171	None	52	277	7	7.36838828
SRR3317843	ENSG00000230844.3	ENST00000421685.2	ZNF674-AS1	LncRNA	Novel	0.007171	None	52	277	7	26.1817433
SRR3317843_alt	ENSG00000230844.3	ENST00000421685.2	ZNF674-AS1	LncRNA	Novel	0.007171	None	52	277	7	26.1817433
SRR3208921	ENSG00000230844.3	ENST00000421685.2	ZNF674-AS1	LncRNA	Novel	0.029214	None	52	277	22	21.7344613
SRR3208921_alt	ENSG00000230844.3	ENST00000421685.2	ZNF674-AS1	LncRNA	Novel	0.029214	None	52	277	22	21.7344613
GSE105082	ENSG00000230844.3	ENST00000421685.2	ZNF674-AS1	LncRNA	Novel	0.000279	None	52	277	34	10.2687294
GSE58207_alt	ENSG00000230844.3	ENST00000421685.2	ZNF674-AS1	LncRNA	Novel	0.000308	4.225E-05	52	277	43	19.6818675
SRR5047771	ENSG00000230844.3	ENST00000421685.2	ZNF674-AS1	LncRNA	Novel	4.875E-06	None	52	277	37	7.52040694
SRR5047772	ENSG00000230844.3	ENST00000421685.2	ZNF674-AS1	LncRNA	Novel	9.929E-05	None	52	277	24	18.8611029
SRR618770,618771,618772,618773_alt	ENSG00000230844.3	ENST00000421685.2	ZNF674-AS1	LncRNA	Novel	1.466E-05	6.304E-05	52	277	22	16.5065902

Min Ribo P value	4.875E-06
Min TIS P value	4.225E-05

Ribo-seq ID	Cell or Tissue	Phenotype	Ribo-seq Source Details	PMID
GSE105082	HELA	Cervical cancer	GSM2817679; GSM2817680	30591072;
GSE58207_alt	HCT116	Colorectal carcinoma	GSM1403307; GSM1403308	25510491;
SRR3208885	ES cell-derived neurons TSC2+/+	WT	GSM2082537	27655340;
SRR3208885_alt	ES cell-derived neurons TSC2+/+	WT	GSM2082537	27655340;
SRR3208921	ES cell-derived neurons TSC2-/-	Tuberous sclerosis complex	GSM2082573	27655340;
SRR3208921_alt	ES cell-derived neurons TSC2-/-	Tuberous sclerosis complex	GSM2082573	27655340;
SRR3317843	U2OS cells	WT	GSM2103080	27406171;
SRR3317843_alt	U2OS cells	WT	GSM2103080	27406171;
SRR4045276	Meg01 cells	WT	GSM2285909	27681415;
SRR5047771	iPSC-differentiated dopamine neurons	Parkinson Disease	NA	NA;
SRR5047772	iPSC-differentiated dopamine neurons	Parkinson Disease	NA	NA;
SRR618770,618771,618772,618773_alt	HEK293	WT	SRR618770; SRR618771; SRR618772; SRR618773	NA;

Database information

No results

Literature information

PMID	31155234;
Cell lines Or Tissues	left ventricle
Phenotype	WT
Gene ID	ENSG00000230844
Transcript ID	ENST00000421685
Symbol	NA
ORF Type	sORF
Gene Type	lincRNA
Throughput	High-throughput Literature Mining
Interaction	NA
Function Description	NA
PMID	26687005;
Cell lines Or Tissues	BJ
Phenotype	NULL
Gene ID	ENSG00000230844
Transcript ID	ENST00000609887
Symbol	NA
ORF Type	sORF
Gene Type	lincRNA
Throughput	High-throughput Literature Mining
Interaction	NA
Function Description	NA

Mass Spectrometry Information

No results

Function and Disease

Functional domain prediction

Analysis	Signature Accession	Signature Description	Start location	Stop location	Score	Status of the match	InterPro accession	InterPro description	GO	Pathways
No results

Disease	Detected
No results

Related Variants

Variant ID	Consequence to sORF	rsID	Ribo-seq ID
No results

Related Small Proteins with Different TISs

SmProt ID	Small Protein Length	Start Codon	Strand	Blocks
SPROHSA156231	37	ATG	+	46546493-46546607
SPROHSA107479	40	ATA	+	46546484-46546607
SPROHSA221227	53	ATG	+	46545607-46545627, 46546465-46546607
SPROHSA366005	61	GTG	+	46545583-46545627, 46546465-46546607
SPROHSA146469	63	ATG	+	46545577-46545627, 46546465-46546607
SPROHSA359362	65	GTG	+	46545571-46545627, 46546465-46546607
SPROHSA32941	83	AAG	+	46545517-46545627, 46546465-46546607

a reliable repository with comprehensive annotation of small proteins derived from ribosome profiling