NyuWa Chinese Population Variant Database

Basic
Region Annotation
Population
Linkage disequilibrium
GWAS Catalog
Epigenetic markers

Variant: 2-203515801-DEL

Allele Count:	709
Allele Number:	20914
Allele Frequency:	0.0339
SVTYPE:	DEL
START:	203515801
END:	203521099
SVLEN:	-5300
Number of Homozygotes:	36

Reference: T2T-CHM13

T2T-specific: not in

Browser:

Region annotation

	Region	Gene ID	Gene Detail
RefSeq	intronic	NBEAL1	.

Allele frequency distribution

Linkage disequilibrium Plot

LD results for 2-203515801-DEL

The R² statistic is the correlation coefficient of genotypes between pairs of loci. D' is the normalized LD statistic by dividing LD statistic D by its theoretical maximum, while D = p_AB - p_A * p_B.

GWAS Catalog

LD SNP	LD R2	Risk Allele	Gene	Trait Class	Trait	OR/Beta	P-value	Study	Ancestry
2-203447953-T-A	AFR:0.30 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs114123510-A	WDR12	Cardiovascular disease	Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease)	1.13	3E-19	GCST004787	European, NR
2-203412714-T-G	AFR:0.33 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs114393235-G		Biological process	Smoking initiation	0.0143	1E-30	GCST90243985	European, East Asian, Hispanic or Latin American, African unspecified
2-203292850-C-T	AFR:0.22 AMR:0.96 EAS: EUR:1.00 SAS:0.93 10K:0.60	rs115400054-C	FAM117B	Lipid or lipoprotein measurement	Cholesterol, total	0.054	5E-9	GCST002896	European
2-203738256-C-G	AFR:0.90 AMR:0.84 EAS:1.00 EUR:0.93 SAS:1.00 10K:0.91	rs115600411-?	CYP20A1	Cardiovascular disease	Non-lobar intracerebral hemorrhage (MTAG)	1.098901	1E-6	GCST008876	European
2-203738256-C-G	AFR:0.90 AMR:0.84 EAS:1.00 EUR:0.93 SAS:1.00 10K:0.91	rs115600411-G	NR	Hematological measurement	Hemoglobin concentration		5E-10	GCST90002314	African American or Afro-Caribbean, African unspecified, European, East Asian, Hispanic or Latin American, South Asian
2-203738256-C-G	AFR:0.90 AMR:0.84 EAS:1.00 EUR:0.93 SAS:1.00 10K:0.91	rs115600411-C	CYP20A1	Other measurement	Periventricular white matter hyperintensities	0.048	7E-8	GCST010726	Hispanic or Latin American, European, African American or Afro-Caribbean
2-203738256-C-G	AFR:0.90 AMR:0.84 EAS:1.00 EUR:0.93 SAS:1.00 10K:0.91	rs115600411-C		Neurological disorder	Insomnia	0.011	2E-10	GCST90131903	European
2-203738256-C-G	AFR:0.90 AMR:0.84 EAS:1.00 EUR:0.93 SAS:1.00 10K:0.91	rs115600411-C		Other measurement	Renin levels	0.136	2E-12	GCST90249281	European
2-203738256-C-G	AFR:0.90 AMR:0.84 EAS:1.00 EUR:0.93 SAS:1.00 10K:0.91	rs115600411-?		Other measurement	T2 brain MRIs Unsupervised Deep learning derived Imaging Phenotypes (dimension 6)		5E-12	GCST90320825	European
2-203510795-C-A	AFR:0.89 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.96	rs115654617-A	NBEAL1	Cardiovascular disease	Coronary artery disease	0.1179	2E-32	GCST005196	NR
2-203698452-C-T	AFR:0.93 AMR:0.92 EAS:1.00 EUR:0.97 SAS:1.00 10K:0.95	rs116219813-T	NR	Hematological measurement	Hemoglobin concentration	0.018803	1E-11	GCST90002310	European
2-203514744-A-G	AFR:1.00 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.98	rs140168762-?		Cardiovascular disease	Myocardial infarction	0.9002	1E-19	GCST90432175	Greater Middle Eastern (Middle Eastern, North African or Persian), European, NR
2-203412489-G-A	AFR:0.33 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs142250318-?		Cardiovascular disease	Coronary artery disease or fibrinogen levels (pleiotropy)		5E-29	GCST90129546	European, South Asian, East Asian, European
2-203310657-A-C	AFR: AMR:0.94 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.86	rs143805266-?		Cardiovascular disease	Myocardial infarction	0.9009	2E-19	GCST90432175	Greater Middle Eastern (Middle Eastern, North African or Persian), European, NR
2-203267724-G-A	AFR: AMR:0.88 EAS:1.00 EUR:0.98 SAS:0.93 10K:0.84	rs143911965-A		Biological process	Smoking initiation	0.0148	1E-32	GCST90243985	European, East Asian, Hispanic or Latin American, African unspecified
2-203509563-T-C	AFR:0.89 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.96	rs145538381-?	NBEAL1	Cardiovascular disease	Non-lobar intracerebral hemorrhage (MTAG)	1.1111112	2E-7	GCST008876	European
2-203343235-G-A	AFR:0.33 AMR:0.96 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs145664840-A		Neurological disorder	Insomnia	0.009	3E-11	GCST90131901	European
2-203568623-T-C	AFR:0.91 AMR:0.90 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.96	rs147932234-?		Cardiovascular disease	Coronary heart disease		1E-10	GCST90446534	European
2-203494025-C-T	AFR:0.89 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.96	rs148812085-T		Cardiovascular disease	Coronary artery disease	1.121	5E-50	GCST90132314	European, NR
2-203393957-C-T	AFR:0.33 AMR:0.98 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs149163995-?	ALS2CR8	Cardiovascular disease	Migraine	1.0822511	4E-10	GCST003986	European
2-203449759-G-A	AFR:0.30 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs149268645-G	NR	Biological process	Suicide attempts in major depressive disorder or bipolar disorder or schizophrenia	1.1764705	4E-7	GCST008123	European
2-203449759-G-A	AFR:0.30 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs149268645-G	NR	Biological process	Suicide attempts in major depressive disorder or bipolar disorder or schizophrenia	1.1764705	4E-7	GCST008123	European
2-203333540-G-C	AFR:0.33 AMR:0.96 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs150622102-C		Neurological disorder	Alzheimer's disease		3E-8	GCST90301303	European, African American or Afro-Caribbean, African unspecified, East Asian, Hispanic or Latin American
2-203521093-T-C	AFR:1.00 AMR:0.96 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.97	rs181256816-C		Other measurement	Vertex-wise cortical thickness	8.87	7E-19	GCST90095131	European
2-203521093-T-C	AFR:1.00 AMR:0.96 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.97	rs181256816-C	NR	Other measurement	Cortical surface area		8E-15	GCST90091060	European
2-203521093-T-C	AFR:1.00 AMR:0.96 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.97	rs181256816-?		Other measurement	Personality traits or cognitive traits (multivariate analysis)		4E-9	GCST90270074	European
2-203521094-G-A	AFR:1.00 AMR:0.96 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.97	rs185726277-A	NR	Other measurement	Cortical thickness		1E-17	GCST90091061	European
2-203345718-C-T	AFR:0.33 AMR:0.96 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs186399184-?	NR	Other measurement	White matter microstructure (radial diusivities)		8E-9	GCST009540	European
2-203345718-C-T	AFR:0.33 AMR:0.96 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs186399184-?	NR	Other measurement	White matter microstructure (radial diusivities)		2E-12	GCST009540	European
2-203345718-C-T	AFR:0.33 AMR:0.96 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs186399184-?	NR	Other measurement	White matter microstructure (radial diusivities)		1E-8	GCST009540	European
2-203345718-C-T	AFR:0.33 AMR:0.96 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs186399184-?	NR	Other measurement	White matter microstructure (radial diusivities)		1E-8	GCST009540	European
2-203345718-C-T	AFR:0.33 AMR:0.96 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs186399184-?	NR	Other measurement	White matter microstructure (fractional anisotropy)		7E-10	GCST009539	European
2-203345718-C-T	AFR:0.33 AMR:0.96 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs186399184-?	NR	Other measurement	White matter microstructure (fractional anisotropy)		4E-8	GCST009539	European
2-203679497-A-T	AFR:0.93 AMR:0.90 EAS:1.00 EUR:0.91 SAS:0.63 10K:0.91	rs188186531-A		Cardiovascular disease	Ischemic stroke (small-vessel)	1.21	4E-7	GCST005841	East Asian, European, African American or Afro-Caribbean, South Asian, Asian unspecified, Hispanic or Latin American
2-203473762-T-G	AFR:0.33 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs188517380-T		Cardiovascular measurement	Pulse pressure	0.02	7E-11	GCST90301701	European
2-203412444-A-G	AFR:0.33 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs191602009-?		Cardiovascular disease	Migraine (MTAG)	0.022	7E-9	GCST90269766	European
2-203412444-A-G	AFR:0.33 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs191602009-?		Cardiovascular disease	Migraine (MTAG)	0.022	7E-9	GCST90269766	European
2-203412444-A-G	AFR:0.33 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs191602009-?		Cardiovascular disease	Small vessel stroke (MTAG)	0.025	8E-9	GCST90103795	European
2-203412444-A-G	AFR:0.33 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs191602009-?		Cardiovascular disease	Small vessel stroke (MTAG)	0.025	8E-9	GCST90103795	European
2-203497785-C-T	AFR:0.89 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.96	rs2351524-?		Cardiovascular disease	Coronary artery disease or plasminogen activator inhibitor 1 levels (pleiotropy)		2E-24	GCST90129548	European, South Asian, East Asian, European
2-203497785-C-T	AFR:0.89 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.96	rs2351524-?		Cardiovascular disease	Coronary artery disease or tissue plasminogen activator levels (pleiotropy)		2E-24	GCST90129547	European, South Asian, East Asian, European
2-203497785-C-T	AFR:0.89 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.96	rs2351524-T	NBEAL1	Other measurement	White matter hyperintensities		6E-9	GCST012580	European, African American or Afro-Caribbean
2-203382498-T-C	AFR:0.33 AMR:0.98 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs35212307-?		Cardiovascular disease	Coronary artery disease		5E-49	GCST90132314	European, NR
2-203382498-T-C	AFR:0.33 AMR:0.98 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs35212307-C	WDR12	Other measurement	White matter hyperintensities		4E-8	GCST012580	European, African American or Afro-Caribbean
2-203515877-A-G	AFR:0.97 AMR:0.90 EAS:1.00 EUR:0.95 SAS:1.00 10K:0.95	rs375380888-G		Other trait	Headache or HbA1c levels	0.97	6E-10	GCST90281122	European
2-203497627-A-G	AFR:0.89 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.96	rs4675310-A		Other trait	Angina pectoris	0.085	4E-9	GCST90018793	European, East Asian
2-203497627-A-G	AFR:0.89 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.96	rs4675310-A		Other measurement	Extensive basal ganglia perivascular space burden		3E-9	GCST90244153	European
2-203369754-G-A	AFR:0.33 AMR:0.98 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs6435169-?		Cardiovascular disease	Body fat percentage or coronary artery disease (MTAG)	0.1334	7E-10	GCST90085924	European, East Asian, South Asian, African American or Afro-Caribbean, European, East Asian, South Asian, African American or Afro-Caribbean, Hispanic or Latin American
2-203369754-G-A	AFR:0.33 AMR:0.98 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs6435169-?		Cardiovascular disease	Body fat percentage or coronary artery disease (MTAG)	0.1334	7E-10	GCST90085924	European, East Asian, South Asian, African American or Afro-Caribbean, European, East Asian, South Asian, African American or Afro-Caribbean, Hispanic or Latin American
2-203278940-A-G	AFR: AMR:0.88 EAS:1.00 EUR:0.99 SAS:0.93 10K:0.85	rs6705330-G		Biological process	Smoking initiation	0.0145	1E-31	GCST90243985	European, East Asian, Hispanic or Latin American, African unspecified
2-203362617-T-C	AFR:0.33 AMR:0.98 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs6725887-C	WDR12	Cardiovascular disease	Myocardial infarction (early onset)	1.17	1E-8	GCST000340	European
2-203362617-T-C	AFR:0.33 AMR:0.98 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs6725887-C	WDR12	Cardiovascular disease	Coronary heart disease	1.14	1E-9	GCST000998	European
2-203362617-T-C	AFR:0.33 AMR:0.98 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs6725887-C	WDR12	Cardiovascular disease	Coronary artery disease	1.14	2E-8	GCST002289	NR
2-203362617-T-C	AFR:0.33 AMR:0.98 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs6725887-C	NR	Cardiovascular disease	Coronary artery disease	1.15	6E-8	GCST011488	South Asian, European
2-203490535-G-A	AFR:0.28 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.89	rs6728861-A	NBEAL1	Cardiovascular disease	Coronary artery disease	0.1054	1E-32	GCST005195	NR
2-203413541-C-G	AFR:0.33 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs72926767-G	CARF	Cardiovascular disease	Myocardial infarction	1.12	1E-21	GCST011365	European, NR, European, NR
2-203413541-C-G	AFR:0.33 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs72926767-?		Cardiovascular disease	Myocardial infarction	0.8998	7E-20	GCST90432175	Greater Middle Eastern (Middle Eastern, North African or Persian), European, NR
2-203421000-C-T	AFR:0.33 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs72926772-T	CARF	Cardiovascular disease	Coronary artery disease	1.13	5E-18	GCST010479	East Asian, European, East Asian
2-203448861-A-G	AFR: AMR:0.94 EAS: EUR:0.92 SAS:1.00 10K:0.56	rs72928605-?	FAM117B, ICA1L, WDR12, CARF, NBEAL1, CYP20A1, ABI2	Other measurement	Brain morphology (MOSTest)		1E-8	GCST010703	European
2-203456367-T-A	AFR:0.30 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs72928613-?		Cardiovascular disease	Headache or migraine		5E-9	GCST90267554	European
2-203463563-A-T	AFR:0.33 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs72932557-T	CARF	Other measurement	White matter hyperintensities		4E-8	GCST012580	European, African American or Afro-Caribbean
2-203266227-G-C	AFR: AMR:0.88 EAS:0.94 EUR:0.98 SAS:0.93 10K:0.85	rs72932727-G	ICA1L	Cardiovascular disease	Non-lobar intracerebral hemorrhage (MTAG)	1.1111112	2E-8	GCST008876	European
2-203266227-G-C	AFR: AMR:0.88 EAS:0.94 EUR:0.98 SAS:0.93 10K:0.85	rs72932727-?		Neurological disorder	Alzheimer’s disease polygenic risk score (upper quantile vs lower quantile)		7E-15	GCST90132260	European
2-203277777-A-T	AFR: AMR:0.88 EAS:1.00 EUR:0.99 SAS:0.93 10K:0.85	rs72932741-T		Biological process	Smoking initiation	0.0145	1E-31	GCST90243985	European, East Asian, Hispanic or Latin American, African unspecified
2-203533274-T-G	AFR:1.00 AMR:0.96 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.97	rs72934505-T	NBEAL1	Other measurement	White matter hyperintensity burden		6E-8	GCST003013	European, African American or Afro-Caribbean, South East Asian, Hispanic or Latin American, East Asian
2-203533274-T-G	AFR:1.00 AMR:0.96 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.97	rs72934505-T	NBEAL1	Other measurement	White matter hyperintensity burden		5E-8	GCST003013	European, African American or Afro-Caribbean, South East Asian, Hispanic or Latin American, East Asian
2-203533274-T-G	AFR:1.00 AMR:0.96 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.97	rs72934505-T	ICA1L, WDR12, CARF, NBEAL1, CYP20A1	Other measurement	White matter hyperintensities	6.793	4E-13	GCST010101	European, African unspecified, Hispanic or Latin American, Asian unspecified
2-203533274-T-G	AFR:1.00 AMR:0.96 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.97	rs72934505-?	ICA1L, WDR12, CARF, NBEAL1, CYP20A1	Other measurement	White matter integrity (fractional anisotropy)		7E-8	GCST010102	European
2-203585748-T-C	AFR: AMR:0.72 EAS: EUR:0.86 SAS: 10K:0.49	rs72934535-T	NBEAL1	Cardiovascular disease	Coronary artery disease	0.128	2E-32	GCST005194	NR
2-203585748-T-C	AFR: AMR:0.72 EAS: EUR:0.86 SAS: 10K:0.49	rs72934535-T	ICA1L, WDR12, CARF, NBEAL1	Cardiovascular disease	Lacunar stroke	1.25	4E-9	GCST90014122	European
2-203585748-T-C	AFR: AMR:0.72 EAS: EUR:0.86 SAS: 10K:0.49	rs72934535-T	WDR12, ICA1L, CARF, NBEAL1	Cardiovascular disease	Lacunar stroke	1.22	5E-8	GCST90014123	African American or Afro-Caribbean, European, Hispanic or Latin American
2-203585748-T-C	AFR: AMR:0.72 EAS: EUR:0.86 SAS: 10K:0.49	rs72934535-?		Cardiovascular disease	Coronary artery disease or von Willebrand factor levels (pleiotropy)		4E-26	GCST90129544	European, South Asian, East Asian, European, African American or Afro-Caribbean, Hispanic or Latin American
2-203585748-T-C	AFR: AMR:0.72 EAS: EUR:0.86 SAS: 10K:0.49	rs72934535-?		Cardiovascular disease	Coronary artery disease or factor VII levels (pleiotropy)		5E-26	GCST90129542	European, South Asian, East Asian, European, African American or Afro-Caribbean
2-203585748-T-C	AFR: AMR:0.72 EAS: EUR:0.86 SAS: 10K:0.49	rs72934535-?		Cardiovascular disease	Coronary artery disease or factor VIII levels (pleiotropy)		4E-26	GCST90129543	European, South Asian, East Asian, European, African American or Afro-Caribbean, East Asian, South Asian, Hispanic or Latin American
2-203585748-T-C	AFR: AMR:0.72 EAS: EUR:0.86 SAS: 10K:0.49	rs72934535-?		Cardiovascular disease	Coronary artery disease or factor XI levels (pleiotropy)		5E-26	GCST90129545	European, South Asian, East Asian, European
2-203585748-T-C	AFR: AMR:0.72 EAS: EUR:0.86 SAS: 10K:0.49	rs72934535-C		Cardiovascular disease	Ischemic heart disease (PheCode 411)		7E-9	GCST008370	European
2-203607571-T-G	AFR: AMR:0.86 EAS: EUR:0.93 SAS:1.00 10K:0.54	rs72934556-G		Other measurement	IDP dMRI TBSS L2 Anterior limb of internal capsule R	0.11	1E-13	GCST90004139	European
2-203621853-A-G	AFR:1.00 AMR:0.92 EAS:1.00 EUR:0.99 SAS:1.00 10K:0.97	rs72934573-G		Cardiovascular disease	Myocardial infarction	0.1351	7E-15	GCST90018877	European, East Asian
2-203625846-T-G	AFR:1.00 AMR:0.92 EAS:1.00 EUR:0.99 SAS:1.00 10K:0.97	rs72934583-T	NBEAL1	Other measurement	Periventricular white matter hyperintensities	0.0529	1E-9	GCST010726	Hispanic or Latin American, European, African American or Afro-Caribbean
2-203625846-T-G	AFR:1.00 AMR:0.92 EAS:1.00 EUR:0.99 SAS:1.00 10K:0.97	rs72934583-T	NBEAL1	Other measurement	White matter hyperintensity volume (adjusted for hypertension)	0.0627	1E-12	GCST011949	African American or Afro-Caribbean, African American or Afro-Caribbean, European
2-203625846-T-G	AFR:1.00 AMR:0.92 EAS:1.00 EUR:0.99 SAS:1.00 10K:0.97	rs72934583-T	NBEAL1	Cardiovascular disease	White matter hyperintensity volume x hypertension interaction (2df)		5E-12	GCST011952	European, African American or Afro-Caribbean
2-203625846-T-G	AFR:1.00 AMR:0.92 EAS:1.00 EUR:0.99 SAS:1.00 10K:0.97	rs72934583-T	NBEAL1	Other measurement	White matter hyperintensity volume	0.0627	7E-13	GCST011946	African American or Afro-Caribbean, European
2-203634725-C-T	AFR:1.00 AMR:0.92 EAS:1.00 EUR:0.99 SAS:1.00 10K:0.97	rs72934589-?	NBEAL1	Cardiovascular disease	Non-lobar intracerebral hemorrhage (MTAG)	1.1111112	2E-7	GCST008876	European
2-203634725-C-T	AFR:1.00 AMR:0.92 EAS:1.00 EUR:0.99 SAS:1.00 10K:0.97	rs72934589-C		Cardiovascular disease	Small vessel stroke	1.16	7E-7	GCST90104543	European
2-203634725-C-T	AFR:1.00 AMR:0.92 EAS:1.00 EUR:0.99 SAS:1.00 10K:0.97	rs72934589-C		Cardiovascular disease	Small vessel stroke (MTAG)	1.19	2E-14	GCST90162546	European
2-203636552-G-A	AFR:1.00 AMR:0.92 EAS:1.00 EUR:0.99 SAS:1.00 10K:0.97	rs72934591-?		Cardiovascular disease	Myocardial infarction	0.9014	3E-19	GCST90432175	Greater Middle Eastern (Middle Eastern, North African or Persian), European, NR
2-203647911-G-A	AFR:0.97 AMR:0.92 EAS:1.00 EUR:0.97 SAS:1.00 10K:0.96	rs72934601-?		Other measurement	Brain morphology (MOSTest)		1E-14	GCST90239729	European
2-203372482-G-A	AFR:0.33 AMR:0.98 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs72934760-A	intergenic	Other measurement	Periventricular white matter hyperintensities	0.054	2E-9	GCST010726	Hispanic or Latin American, European, African American or Afro-Caribbean
2-203653132-T-G	AFR:0.97 AMR:0.92 EAS:1.00 EUR:0.97 SAS:1.00 10K:0.96	rs72936304-T		Other measurement	Renin levels	0.0821	3E-10	GCST90012038	European
2-203405678-T-C	AFR:0.33 AMR:1.00 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs72936869-?	ALS2CR8	Cardiovascular disease	Non-lobar intracerebral hemorrhage (MTAG)	1.1111112	1E-7	GCST008876	European
2-203738174-C-G	AFR:0.90 AMR:0.84 EAS:1.00 EUR:0.93 SAS:1.00 10K:0.91	rs72938315-?		Other disease	Respiratory diseases		2E-8	GCST007076	European
2-203738174-C-G	AFR:0.90 AMR:0.84 EAS:1.00 EUR:0.93 SAS:1.00 10K:0.91	rs72938315-C	CYP20A1	Other measurement	Appendicular lean mass	0.0207	7E-15	GCST90000025	European
2-203738174-C-G	AFR:0.90 AMR:0.84 EAS:1.00 EUR:0.93 SAS:1.00 10K:0.91	rs72938315-G	NR	Lipid or lipoprotein measurement	Apolipoprotein B levels	0.0263	2E-14	GCST90019496	European, African unspecified, South Asian
2-203738174-C-G	AFR:0.90 AMR:0.84 EAS:1.00 EUR:0.93 SAS:1.00 10K:0.91	rs72938315-G	NR	Lipid or lipoprotein measurement	Total cholesterol levels	0.027	2E-15	GCST90019501	European, African unspecified, South Asian
2-203738174-C-G	AFR:0.90 AMR:0.84 EAS:1.00 EUR:0.93 SAS:1.00 10K:0.91	rs72938315-G	NR	Liver enzyme measurement	Serum alkaline phosphatase levels	0.0305	4E-19	GCST90019494	European, African unspecified, South Asian
2-203738174-C-G	AFR:0.90 AMR:0.84 EAS:1.00 EUR:0.93 SAS:1.00 10K:0.91	rs72938315-G	NR	Lipid or lipoprotein measurement	Low density lipoprotein cholesterol levels	0.0254	1E-13	GCST90019512	European, African unspecified, South Asian
2-203289818-G-A	AFR: AMR:0.94 EAS:1.00 EUR:1.00 SAS:0.93 10K:0.86	rs74675536-?	NR	Other measurement	White matter microstructure (mean diusivities)		2E-11	GCST009538	European
2-203289818-G-A	AFR: AMR:0.94 EAS:1.00 EUR:1.00 SAS:0.93 10K:0.86	rs74675536-?	NR	Other measurement	White matter microstructure (mean diusivities)		5E-8	GCST009538	European
2-203369810-T-C	AFR:0.33 AMR:0.98 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs7582720-?	WDR12	Cardiovascular disease	Coronary artery disease or ischemic stroke		4E-9	GCST002287	NR
2-203369810-T-C	AFR:0.33 AMR:0.98 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs7582720-?	WDR12	Cardiovascular disease	Coronary artery disease or large artery stroke		3E-8	GCST002290	NR
2-203397246-A-G	AFR:0.33 AMR:0.98 EAS:1.00 EUR:1.00 SAS:1.00 10K:0.90	rs7603972-A	CARF1	Other measurement	White matter hyperintensity volume	0.07	2E-13	GCST011947	European
2-203281673-C-G	AFR: AMR:0.88 EAS:1.00 EUR:0.99 SAS:0.93 10K:0.85	rs76122535-G	ICA1L, WDR12, CARF, NBEAL1	Other measurement	White matter integrity (fractional anisotropy)	0.360912	6E-9	GCST010102	European
2-203281673-C-G	AFR: AMR:0.88 EAS:1.00 EUR:0.99 SAS:0.93 10K:0.85	rs76122535-G		Other measurement	White matter fractional anisotropy x age interaction (2df)		4E-12	GCST90100584	European
2-203280719-C-T	AFR: AMR:0.88 EAS:1.00 EUR:0.99 SAS:0.93 10K:0.85	rs78128841-T		Biological process	Smoking initiation	0.0145	1E-31	GCST90243985	European, East Asian, Hispanic or Latin American, African unspecified

Epigenetic markers

Marker	Cell type	Range
H3K27ac	22Rv1	203517452_203517841
H3K27ac	RWPE2	203519522_203521755
H3K27ac	RWPE1	203520112_203521347
H3K27ac	VCaP	203517056_203518549
H3K27ac	epithelial_cell_of_prostate_male	203519519_203521634;203517565_203517987
H3K36me3	MG63	203520308_203521397
H3K36me3	SJCRH30	203519789_203520656
H3K4me1	Caco-2	203521018_203523964;203519970_203520405
H3K4me1	HAP-1	203517627_203518686

Fixation index Fst

The Fixation index Fst was adopted as the measure for assessing population differences.

NyuWa Global 10K T2T Variant Database

Variant Database and Imputation service with world population genome resource

Variant: 2-203515801-DEL

Reference: T2T-CHM13

T2T-specific: not in

Browser:

LD results for 2-203515801-DEL

NyuWa Global 10K T2T Variant Database

Variant Database and Imputation service with world population genome resource

Variant: 2-203515801-DEL

Reference: T2T-CHM13 T2T-specific: not in

Browser: Browser

LD results for 2-203515801-DEL

Reference: T2T-CHM13

T2T-specific: not in

Browser: