SmProt

Specific Information of Small Protein : SPROHSA388937

General Information

Small Protein ID	SPROHSA388937
Organism	Human (Homo sapiens)
Small Protein Sequence	LVATLGRLVGGHPTLPSSMETRRESPA*
RNA Sequence	TTGGTTGCCACACTGGGGAGACTGGTGGGTGGTCACCCCACCCTACCCTCATCCATGGAAACCCGGAGGGAGAGTCCCGCCTGA
Protein Length	27
Start Codon	TTG
Location	chr1:203627106-203627190:+
Blocks	203627106-203627190
Mean PhyloCSF	-4.39378574916
Data Source	Ribosome profiling;
Related Genes	ENSG00000058668; ATP2B4; NONHSAG105657;
Mass (Da)	mono. 2831.5; avg. 2833.2

Ribosome profiling

Ribo-seq ID	Ensembl Gene ID	Ensembl Transcript ID	Symbol	Gene Type	TIS Type	Ribo P value	TIS P value	Start On Trans	Stop On Trans	In-frame Count	Ribo-seq RPKM
SRR3208885_alt	ENSG00000058668.14	ENST00000367218.7	ATP2B4	Protein_coding	5'UTR	0.001435	None	320	404	66	141.162322
GSE45785_1_alt	ENSG00000058668.14	ENST00000367218.7	ATP2B4	Protein_coding	5'UTR	0.001443	None	320	404	22	171.704797
GSE45833_2_alt	ENSG00000058668.14	ENST00000367218.7	ATP2B4	Protein_coding	5'UTR	0.003826	None	320	404	24	39.2344765
GSE45833_6_alt	ENSG00000058668.14	ENST00000367218.7	ATP2B4	Protein_coding	5'UTR	0.00707	None	320	404	77	156.633493
SRR3208921_alt	ENSG00000058668.14	ENST00000367218.7	ATP2B4	Protein_coding	5'UTR	0.030472	None	320	404	87	230.222987
GSE129869_alt	ENSG00000058668.14	ENST00000367218.7	ATP2B4	Protein_coding	5'UTR	0.001486	None	320	404	17	367.362892
GSE103308_alt	ENSG00000058668.14	ENST00000367218.7	ATP2B4	Protein_coding	5'UTR	0.000459	None	320	404	23	24.3557166
GSE105082_alt	ENSG00000058668.14	ENST00000367218.7	ATP2B4	Protein_coding	5'UTR	0.000927	None	320	404	14	11.3258045
GSE94613_2_alt	ENSG00000058668.14	ENST00000367218.7	ATP2B4	Protein_coding	5'UTR	0.000429	None	320	404	54	133.768272
GSE94613_1_alt	ENSG00000058668.14	ENST00000367218.7	ATP2B4	Protein_coding	5'UTR	0.008445	None	320	404	22	151.287807
SRR7207252_alt	ENSG00000058668.14	ENST00000367218.7	ATP2B4	Protein_coding	5'UTR	0.01221	None	320	404	11	34.6308348
SRR2991181_alt	ENSG00000058668.14	ENST00000367218.7	ATP2B4	Protein_coding	5'UTR	0.025468	None	320	404	14	27.2412967
SRR964946_alt	ENSG00000058668.14	ENST00000367218.7	ATP2B4	Protein_coding	5'UTR	0.000261	0.007775	320	404	NA	NA
SRR3208885_alt	ENSG00000058668.14	ENST00000357681.9	ATP2B4	Protein_coding	5'UTR	0.001435	None	546	630	66	141.162322
GSE45785_1_alt	ENSG00000058668.14	ENST00000357681.9	ATP2B4	Protein_coding	5'UTR	0.001443	None	546	630	22	171.704797
GSE45833_2_alt	ENSG00000058668.14	ENST00000357681.9	ATP2B4	Protein_coding	5'UTR	0.003826	None	546	630	24	39.2344765
GSE45833_6_alt	ENSG00000058668.14	ENST00000357681.9	ATP2B4	Protein_coding	5'UTR	0.00707	None	546	630	77	156.633493
SRR3208921_alt	ENSG00000058668.14	ENST00000357681.9	ATP2B4	Protein_coding	5'UTR	0.030472	None	546	630	87	230.222987
GSE129869_alt	ENSG00000058668.14	ENST00000357681.9	ATP2B4	Protein_coding	5'UTR	0.001486	None	546	630	17	367.362892
GSE103308_alt	ENSG00000058668.14	ENST00000357681.9	ATP2B4	Protein_coding	5'UTR	0.000459	None	546	630	23	24.3557166
GSE105082_alt	ENSG00000058668.14	ENST00000357681.9	ATP2B4	Protein_coding	5'UTR	0.000927	None	546	630	14	11.3258045
GSE94613_2_alt	ENSG00000058668.14	ENST00000357681.9	ATP2B4	Protein_coding	5'UTR	0.000429	None	546	630	54	133.768272
GSE94613_1_alt	ENSG00000058668.14	ENST00000357681.9	ATP2B4	Protein_coding	5'UTR	0.008445	None	546	630	22	151.287807
SRR7207252_alt	ENSG00000058668.14	ENST00000357681.9	ATP2B4	Protein_coding	5'UTR	0.01221	None	546	630	11	34.6308348
SRR2991181_alt	ENSG00000058668.14	ENST00000357681.9	ATP2B4	Protein_coding	5'UTR	0.025468	None	546	630	14	27.2412967
SRR964946_alt	ENSG00000058668.14	ENST00000357681.9	ATP2B4	Protein_coding	5'UTR	0.000261	0.007775	546	630	NA	NA

Min Ribo P value	0.000261
Min TIS P value	None

Ribo-seq ID	Cell or Tissue	Phenotype	Ribo-seq Source Details	PMID
GSE103308_alt	RD-muscle	WT	GSM2760247	29696588;
GSE105082_alt	HELA	Cervical cancer	GSM2817679; GSM2817680	30591072;
GSE129869_alt	Foreskin Fibroblasts	WT	GSM3723750; GSM3723751; GSM3723752	31167946;
GSE45785_1_alt	BJ cells	WT	GSM1115204	23594524;
GSE45833_2_alt	BJ cells	Quiescence	GSM1047586; GSM1047587	23594524;
GSE45833_6_alt	BJ cells	Transformed	GSM1047591	23594524;
GSE94613_1_alt	MOLM13	Acute myeloid leukemia	GSM2481052	29186125;
GSE94613_2_alt	MOLM13	Acute myeloid leukemia	GSM2481053	29186125;
SRR2991181_alt	SH-SY5Y	Neuroblastoma	GSM1970518	31109297;
SRR3208885_alt	ES cell-derived neurons TSC2+/+	WT	GSM2082537	27655340;
SRR3208921_alt	ES cell-derived neurons TSC2-/-	Tuberous sclerosis complex	GSM2082573	27655340;
SRR7207252_alt	MCF10A-ER-Src	Breast adenocarcinoma	GSM3150265	30089253;
SRR964946_alt	HEK293	WT	SRR964946	22927429;

Database information

No results

Literature information

No results

Mass Spectrometry Information

No results

Function and Disease

Functional domain prediction

Analysis	Signature Accession	Signature Description	Start location	Stop location	Score	Status of the match	InterPro accession	InterPro description	GO	Pathways
MobiDBLite	mobidb-lite	consensus disorder prediction	1	27	-	T

Disease	Detected
No results

Related Variants

Variant ID	Consequence to sORF	rsID	Ribo-seq ID
1-203627152-C-T	Non-Synonymous p.P16S	rs76857273	SRR5047771
1-203627190-A-G	Stop Loss p.*28W	rs4600103	SRR3208885; SRR3208921; SRR4045276; SRR5047770; SRR5047771; SRR5047772; SRR5239056; SRR5239058; SRR5350745; SRR5382423; SRR6053333; SRR7207252; SRR8907185; SRR8907187; SRR8310196; SRR8310197; SRR8310201; SRR8310198; SRR8310199; SRR8310200; SRR8310205; SRR627622; SRR627623; SRR627625; SRR627626; SRR627627; SRR810100; SRR810101; SRR810102; SRR810103; SRR810104; SRR1795425; SRR964946

Related Small Proteins with Different TISs

SmProt ID	Small Protein Length	Start Codon	Strand	Blocks
SPROHSA179558	9	ATG	+	203627160-203627190
SPROHSA303150	23	CTG	+	203627118-203627190
SPROHSA73982	37	AGG	+	203627076-203627190

a reliable repository with comprehensive annotation of small proteins derived from ribosome profiling