Frequently Asked Questions

No result returned for a UniProt ID?

The database contains 7,653 candidate proteins. A blank result usually indicates that the queried UniProt ID is outside this set or has been entered incorrectly. Please verify the identifier and try again.

Prolonged loading for database-resident complexes?

The PAE files provided for multi-chain complexes are roughly 70 MB each. Depending on your connection speed and the rendering capability of your browser, loading and visualisation may take between 0 and 3 minutes. Re-submission before completion is discouraged.

What is the source of the candidate proteins in the database?

The proteins were principally derived from the human entries in UniProt, selecting one canonical sequence per gene, with 20654 proteins. After analysis with GO enrichment of cellular component, a final set of 7655 nuclear proteins was retained for subsequent workflows. Of the original 7,655 nuclear proteins, two were longer than 8,000 residues and were dropped, leaving 7,653 proteins to be analysed in prediction. If this database contributes to a publication, please cite the associated article.

How were the parameters for structure prediction determined?

Template structures dated 30 September 2021 were employed, and an identical random seed was specified to maximize comparability across predictions.

Are post-translational modifications included for histone in the structure prediction?

No. Histones in nucleosome were modeled without any post-translational modifications.

Does the structure prediction of histone include its tail domain?

No. The tail of histone was excluded from the structural model.