Welcome to Our Platform
We are dedicated to providing a comprehensive suite of tools and resources to support researchers and developers. Our platform offers state-of-the-art solutions tailored to your needs.
Features of Our Platform
- The platform hosts AF3 structures of nearly all human nuclear protein with nucleosome core particle.
- It offers integrated functions for online viewing, downloading, and analyzing these structures.
- Specialized analysis tools are available for both experimentally determined structures and AF2/AF3 predicted structures.
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About Our Laboratory
Research Focus: Dynamics of Chromatin Structure and Epigenetic Regulation
Various essential life processes in eukaryotes, such as DNA replication, gene transcription, DNA damage repair, and genome stability maintenance, are regulated by epigenetic mechanisms. The dynamic changes in chromatin structure play a critical role in modulating DNA folding, forming the foundation for epigenetic regulation. Modifications to the molecular structure and composition of DNA and histones can induce dynamic changes in chromatin structure. These changes, along with a variety of epigenetic factors such as histone variants, histone chaperones, histone modification enzymes, chromatin remodeling complexes, and non-coding RNAs, collaboratively regulate chromatin dynamics and ensure the orderly execution of vital biological activities. Our research group is dedicated to studying the regulation of chromatin dynamics and its epigenetic functions. Key discoveries include the recognition mechanisms of histone variants, the fundamental principles of “nucleosome editing,” and the determinants of DNA damage repair pathways.
"Nucleosome editing" refers to the process by which chromatin remodeling complexes catalyze the replacement of canonical H2A with the histone variant H2A.Z and precisely target it to specific genomic regions. Dysregulation of this process is closely linked to various diseases, including cancer. We aim to elucidate the mechanisms underlying nucleosome editing and develop techniques for artificial control of nucleosome editing. The mechanisms by which cells determine DNA damage repair pathways are crucial for maintaining genome stability. The discovery of DNA damage-induced synthetic lethality has led to the development of first-line anticancer drugs such as PARP inhibitors. We seek to understand how cells choose different repair pathways for DNA damage repair and to identify novel drug targets for anticancer drug development.
We employ structural biology, biochemistry, biophysics, yeast genetics, and single-molecule force spectroscopy to conduct these studies.