Interaction ID

ncRI-40983474

Interaction Molecules

MIR17HG -- LONP1

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

RISE database

Tags

Organism

Homo sapiens

Tissue or Cell Type

HEK293

Experiment

CLASH

Description

RNA-RNA interaction from RISE database

Alias

-

Class

ncRNA

Ensembl id

ENSG00000215417

Description

ncRNA

Alias

-

Class

mRNA

Ensembl id

ENSG00000196365

Description

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single- stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site- specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575).