Interaction: ncRI-40981401

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Interaction Profile

Interaction ID

ncRI-40981401

Interaction Molecules

hsa-miR-500a-3p -- FADS2

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

RISE database

Tags

Organism

Homo sapiens

Tissue or Cell Type

HEK293

Experiment

CLASH

Description

RNA-RNA interaction from RISE database

Molecule Profile

hsa-miR-500a-3p

⇔

FADS2

Alias

hsa-miR-500a-5p;MIR500A;hsa-miR-500a

Class

miRNA

miRBase id

MI0003184

Description

Homo sapiens miR-500a stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSG00000134824

Description

Acts as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n- 3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n- 3), respectively (PubMed:12713571). Subsequently, in the biosynthetic pathway of HUFA n-3 series, desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). Desaturates palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum (PubMed:12713571). Also desaturates (11E)-octadecenoate (trans- vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity).

Reference Information
Pubmed ID 23622248 Journal Cell
Title Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding.
Author Helwak A, Kudla G, Dudnakova T, Tollervey D
Network View
Disease Annotation
Molecule Disease Data Source
hsa-miR-500a-3p acute T cell leukemia MNDR Database
hsa-miR-500a-3p Adrenocortical Carcinoma MNDR Database
hsa-miR-500a-3p Alzheimer's disease MNDR Database
hsa-miR-500a-3p amyotrophic lateral sclerosis MNDR Database
hsa-miR-500a-3p autosomal recessive disease MNDR Database
hsa-miR-500a-3p autosomal recessive limb-girdle muscular dystrophy type 2B MNDR Database
hsa-miR-500a-3p brain disease MNDR Database
hsa-miR-500a-3p breast cancer MNDR Database
hsa-miR-500a-3p Breast Neoplasms MNDR Database
hsa-miR-500a-3p cancer MNDR Database
hsa-miR-500a-3p carcinoma MNDR Database
hsa-miR-500a-3p Carcinoma, Ductal, Breast MNDR Database
hsa-miR-500a-3p Carcinoma, Renal Cell MNDR Database
hsa-miR-500a-3p cholangiocarcinoma MNDR Database
hsa-miR-500a-3p chronic lymphocytic leukemia MNDR Database
hsa-miR-500a-3p colon adenocarcinoma MNDR Database
hsa-miR-500a-3p colon cancer MNDR Database
hsa-miR-500a-3p colorectal cancer MNDR Database
hsa-miR-500a-3p dilated cardiomyopathy MNDR Database
hsa-miR-500a-3p distal muscular dystrophy MNDR Database
hsa-miR-500a-3p Down syndrome MNDR Database
hsa-miR-500a-3p eye disease MNDR Database
hsa-miR-500a-3p familiar ovarian carcinoma MNDR Database
hsa-miR-500a-3p Friedreich ataxia MNDR Database
hsa-miR-500a-3p Gait Ataxia MNDR Database
hsa-miR-500a-3p gastric adenocarcinoma MNDR Database
hsa-miR-500a-3p Glioblastoma MNDR Database
hsa-miR-500a-3p head and neck squamous cell carcinoma MNDR Database
hsa-miR-500a-3p Heart Failure MNDR Database
hsa-miR-500a-3p hepatocellular carcinoma MNDR Database
hsa-miR-500a-3p Her2-receptor positive breast cancer MNDR Database
hsa-miR-500a-3p Hodgkin's lymphoma MNDR Database
hsa-miR-500a-3p interstitial cystitis MNDR Database
hsa-miR-500a-3p leukemia MNDR Database
hsa-miR-500a-3p liposarcoma MNDR Database
hsa-miR-500a-3p lung adenocarcinoma MNDR Database
hsa-miR-500a-3p lung cancer MNDR Database
hsa-miR-500a-3p lung disease MNDR Database
hsa-miR-500a-3p lung squamous cell carcinoma MNDR Database
hsa-miR-500a-3p lupus nephritis MNDR Database
hsa-miR-500a-3p Lupus Vulgaris MNDR Database
hsa-miR-500a-3p Machado-Joseph disease MNDR Database
hsa-miR-500a-3p malignant glioma MNDR Database
hsa-miR-500a-3p medulloblastoma MNDR Database
hsa-miR-500a-3p melanoma MNDR Database
hsa-miR-500a-3p multiple myeloma MNDR Database
hsa-miR-500a-3p Myasthenia Gravis, Autoimmune, Experimental MNDR Database
hsa-miR-500a-3p nasopharynx carcinoma MNDR Database
hsa-miR-500a-3p nephroblastoma MNDR Database
hsa-miR-500a-3p neurodegenerative disease MNDR Database
hsa-miR-500a-3p neuromyelitis optica MNDR Database
hsa-miR-500a-3p ovarian carcinoma MNDR Database
hsa-miR-500a-3p ovarian clear cell carcinoma MNDR Database
hsa-miR-500a-3p Ovarian Neoplasms MNDR Database
hsa-miR-500a-3p pancreatic adenocarcinoma MNDR Database
hsa-miR-500a-3p pancreatic cancer MNDR Database
hsa-miR-500a-3p papillary renal cell carcinoma MNDR Database
hsa-miR-500a-3p progesterone-receptor negative breast cancer MNDR Database
hsa-miR-500a-3p progesterone-receptor positive breast cancer MNDR Database
hsa-miR-500a-3p prostate adenocarcinoma MNDR Database
hsa-miR-500a-3p relapsing-remitting multiple sclerosis MNDR Database
hsa-miR-500a-3p renal cell carcinoma MNDR Database
hsa-miR-500a-3p renal clear cell carcinoma MNDR Database
hsa-miR-500a-3p retinoblastoma MNDR Database
hsa-miR-500a-3p Seizures MNDR Database
hsa-miR-500a-3p stomach cancer MNDR Database
hsa-miR-500a-3p stomach carcinoma MNDR Database
hsa-miR-500a-3p Stroke, Lacunar MNDR Database
hsa-miR-500a-3p Subarachnoid Hemorrhage, Traumatic MNDR Database
hsa-miR-500a-3p tonsil cancer MNDR Database
hsa-miR-500a-3p urinary bladder cancer MNDR Database
hsa-miR-500a-3p uterine corpus endometrial carcinoma MNDR Database
hsa-miR-500a-3p vascular disease MNDR Database