Interaction ID
ncRI-40969679
Interaction Molecules
miR-1254 -- PSMD10
Interaction Level
RNA-RNA
Interaction Class
regulatory
Data Source
Literature mining
Tags
Organism
Homo sapiens
Tissue or Cell Type
HEK293T;HCT116;SW1116
Experiment
Luciferase reporter assay
Description
PSMD10 was a target gene of miR-1254
Alias
-
Class
mRNA
UniProt id
Description
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.
| Pubmed ID | 28296190 | Journal | Journal of digestive diseases |
|---|---|---|---|
| Title | MicroRNA-1254 inhibits the migration of colon adenocarcinoma cells by targeting PSMD10. | ||
| Author | Chu YM, Peng HX, Xu Y, Yang DM, Zhou FL, Li J, Kuai R, Lin Y | ||