Interaction ID
ncRI-40652995
Interaction Molecules
hsa-miR-664a-3p -- WDR61
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
T-REx-293T
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSG00000140395
Description
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C.
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-664a-3p | acute T cell leukemia | MNDR Database |
| hsa-miR-664a-3p | adrenocortical carcinoma | MNDR Database |
| hsa-miR-664a-3p | B-cell lymphoma | MNDR Database |
| hsa-miR-664a-3p | bladder urothelial carcinoma | MNDR Database |
| hsa-miR-664a-3p | breast cancer | MNDR Database |
| hsa-miR-664a-3p | Breast Neoplasms | MNDR Database |
| hsa-miR-664a-3p | cancer | MNDR Database |
| hsa-miR-664a-3p | Carcinoma, Renal Cell | MNDR Database |
| hsa-miR-664a-3p | cervical squamous cell carcinoma | MNDR Database |
| hsa-miR-664a-3p | cholangiocarcinoma | MNDR Database |
| hsa-miR-664a-3p | Chronic Pain | MNDR Database |
| hsa-miR-664a-3p | colon adenocarcinoma | MNDR Database |
| hsa-miR-664a-3p | colon cancer | MNDR Database |
| hsa-miR-664a-3p | colorectal cancer | MNDR Database |
| hsa-miR-664a-3p | esophageal carcinoma | MNDR Database |
| hsa-miR-664a-3p | familiar ovarian carcinoma | MNDR Database |
| hsa-miR-664a-3p | gastric adenocarcinoma | MNDR Database |
| hsa-miR-664a-3p | Glioblastoma | MNDR Database |
| hsa-miR-664a-3p | head and neck squamous cell carcinoma | MNDR Database |
| hsa-miR-664a-3p | hepatocellular carcinoma | MNDR Database |
| hsa-miR-664a-3p | Her2-receptor positive breast cancer | MNDR Database |
| hsa-miR-664a-3p | Hodgkin's lymphoma | MNDR Database |
| hsa-miR-664a-3p | Huntington's disease | MNDR Database |
| hsa-miR-664a-3p | leukemia | MNDR Database |
| hsa-miR-664a-3p | liposarcoma | MNDR Database |
| hsa-miR-664a-3p | lung adenocarcinoma | MNDR Database |
| hsa-miR-664a-3p | lung cancer | MNDR Database |
| hsa-miR-664a-3p | lung squamous cell carcinoma | MNDR Database |
| hsa-miR-664a-3p | malignant glioma | MNDR Database |
| hsa-miR-664a-3p | malignant pleural mesothelioma | MNDR Database |
| hsa-miR-664a-3p | medulloblastoma | MNDR Database |
| hsa-miR-664a-3p | melanoma | MNDR Database |
| hsa-miR-664a-3p | multiple sclerosis | MNDR Database |
| hsa-miR-664a-3p | Myasthenia Gravis, Autoimmune, Experimental | MNDR Database |
| hsa-miR-664a-3p | nasopharynx carcinoma | MNDR Database |
| hsa-miR-664a-3p | nephroblastoma | MNDR Database |
| hsa-miR-664a-3p | neuromyelitis optica | MNDR Database |
| hsa-miR-664a-3p | oral squamous cell carcinoma | MNDR Database |
| hsa-miR-664a-3p | osteosarcoma | MNDR Database |
| hsa-miR-664a-3p | ovarian carcinoma | MNDR Database |
| hsa-miR-664a-3p | Ovarian Neoplasms | MNDR Database |
| hsa-miR-664a-3p | pancreatic adenocarcinoma | MNDR Database |
| hsa-miR-664a-3p | pancreatic cancer | MNDR Database |
| hsa-miR-664a-3p | papillary renal cell carcinoma | MNDR Database |
| hsa-miR-664a-3p | Parkinson's disease | MNDR Database |
| hsa-miR-664a-3p | Precursor Cell Lymphoblastic Leukemia-Lymphoma | MNDR Database |
| hsa-miR-664a-3p | progesterone-receptor negative breast cancer | MNDR Database |
| hsa-miR-664a-3p | progesterone-receptor positive breast cancer | MNDR Database |
| hsa-miR-664a-3p | prolactinoma | MNDR Database |
| hsa-miR-664a-3p | prostate adenocarcinoma | MNDR Database |
| hsa-miR-664a-3p | rectum adenocarcinoma | MNDR Database |
| hsa-miR-664a-3p | relapsing-remitting multiple sclerosis | MNDR Database |
| hsa-miR-664a-3p | renal clear cell carcinoma | MNDR Database |
| hsa-miR-664a-3p | small intestine cancer | MNDR Database |
| hsa-miR-664a-3p | thyroid carcinoma | MNDR Database |
| hsa-miR-664a-3p | uterine corpus endometrial carcinoma | MNDR Database |
| hsa-miR-664a-3p | Uterine Cervical Neoplasms | MNDR Database |