Interaction: ncRI-40649757

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Interaction Profile

Interaction ID

ncRI-40649757

Interaction Molecules

hsa-miR-22-3p -- ZFP91

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

TargetScan with Ago CLIP data

Tags

Organism

Homo sapiens

Tissue or Cell Type

T-REx-293T;HEK293S

Experiment

AGO CLIP

Description

Conserved miRNAs target sites predicted by TargetScan and miRanda overlap with the AGO CLIP dataset

Molecule Profile

hsa-miR-22-3p

⇔

ZFP91

Alias

-

Class

miRNA

miRBase id

MI0000078

Description

Homo sapiens miR-22 stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSG00000186660

Description

Atypical E3 ubiquitin-protein ligase that mediates 'Lys- 63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.

Reference Information
Pubmed ID 23824327 Journal Genes & development
Title Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
Author Karginov FV, Hannon GJ
Pubmed ID 29273203 Journal Journal of molecular biology
Title Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets.
Author Li Y, Estep JA, Karginov FV
Network View
Disease Annotation
Molecule Disease Data Source
hsa-miR-22-3p acute myeloid leukemia MNDR Database
hsa-miR-22-3p acute myocardial infarction MNDR Database
hsa-miR-22-3p acute T cell leukemia MNDR Database
hsa-miR-22-3p adenocarcinoma MNDR Database
hsa-miR-22-3p adenoma MNDR Database
hsa-miR-22-3p Adenoviridae Infections MNDR Database
hsa-miR-22-3p adrenocortical carcinoma MNDR Database
hsa-miR-22-3p Adrenocortical Carcinoma MNDR Database
hsa-miR-22-3p Alzheimer's disease MNDR Database
hsa-miR-22-3p amyotrophic lateral sclerosis MNDR Database
hsa-miR-22-3p anencephaly MNDR Database
hsa-miR-22-3p anxiety disorder MNDR Database
hsa-miR-22-3p arthritis MNDR Database
hsa-miR-22-3p asthma MNDR Database
hsa-miR-22-3p autosomal recessive disease MNDR Database
hsa-miR-22-3p azoospermia MNDR Database
hsa-miR-22-3p B-cell lymphoma MNDR Database
hsa-miR-22-3p bladder urothelial carcinoma MNDR Database
hsa-miR-22-3p bone disease MNDR Database
hsa-miR-22-3p brain disease MNDR Database
hsa-miR-22-3p brain stem cancer MNDR Database
hsa-miR-22-3p breast cancer MNDR Database
hsa-miR-22-3p Breast Neoplasms MNDR Database
hsa-miR-22-3p Burkitt lymphoma MNDR Database
hsa-miR-22-3p cancer MNDR Database
hsa-miR-22-3p carcinoma MNDR Database
hsa-miR-22-3p Carcinoma, Ductal, Breast MNDR Database
hsa-miR-22-3p Carcinoma, Non-Small-Cell Lung MNDR Database
hsa-miR-22-3p Carcinoma, Renal Cell MNDR Database
hsa-miR-22-3p Cerebral Hemorrhage, Traumatic MNDR Database
hsa-miR-22-3p cervical squamous cell carcinoma MNDR Database
hsa-miR-22-3p cholangiocarcinoma MNDR Database
hsa-miR-22-3p chronic lymphocytic leukemia MNDR Database
hsa-miR-22-3p colon adenocarcinoma MNDR Database
hsa-miR-22-3p colon cancer MNDR Database
hsa-miR-22-3p colorectal cancer MNDR Database
hsa-miR-22-3p Crohn's disease MNDR Database
hsa-miR-22-3p dermatomyositis MNDR Database
hsa-miR-22-3p diabetes mellitus MNDR Database
hsa-miR-22-3p dilated cardiomyopathy MNDR Database
hsa-miR-22-3p Down syndrome MNDR Database
hsa-miR-22-3p Duchenne muscular dystrophy MNDR Database
hsa-miR-22-3p encephalomyelitis MNDR Database
hsa-miR-22-3p endometrial cancer MNDR Database
hsa-miR-22-3p endometriosis MNDR Database
hsa-miR-22-3p esophageal cancer MNDR Database
hsa-miR-22-3p esophageal carcinoma MNDR Database
hsa-miR-22-3p eye disease MNDR Database
hsa-miR-22-3p familiar ovarian carcinoma MNDR Database
hsa-miR-22-3p gastric adenocarcinoma MNDR Database
hsa-miR-22-3p Glioblastoma MNDR Database
hsa-miR-22-3p gout MNDR Database
hsa-miR-22-3p Graves' disease MNDR Database
hsa-miR-22-3p head and neck cancer MNDR Database
hsa-miR-22-3p head and neck squamous cell carcinoma MNDR Database
hsa-miR-22-3p heart disease MNDR Database
hsa-miR-22-3p Heart Failure MNDR Database
hsa-miR-22-3p hepatitis B MNDR Database
hsa-miR-22-3p hepatocellular carcinoma MNDR Database
hsa-miR-22-3p Her2-receptor positive breast cancer MNDR Database
hsa-miR-22-3p Hodgkin's lymphoma MNDR Database
hsa-miR-22-3p Huntington's disease MNDR Database
hsa-miR-22-3p Hyperalgesia MNDR Database
hsa-miR-22-3p hypersensitivity reaction type II disease MNDR Database
hsa-miR-22-3p hypertension MNDR Database
hsa-miR-22-3p inclusion body myositis MNDR Database
hsa-miR-22-3p Inflammation MNDR Database
hsa-miR-22-3p intellectual disability MNDR Database
hsa-miR-22-3p interstitial cystitis MNDR Database
hsa-miR-22-3p intracranial aneurysm MNDR Database
hsa-miR-22-3p Intracranial Hemorrhage, Hypertensive MNDR Database
hsa-miR-22-3p intrahepatic cholangiocarcinoma MNDR Database
hsa-miR-22-3p kidney cancer MNDR Database
hsa-miR-22-3p kidney disease MNDR Database
hsa-miR-22-3p large cell neuroendocrine cancer MNDR Database
hsa-miR-22-3p leukemia MNDR Database
hsa-miR-22-3p liver disease MNDR Database
hsa-miR-22-3p Liver Neoplasms MNDR Database
hsa-miR-22-3p lung adenocarcinoma MNDR Database
hsa-miR-22-3p lung cancer MNDR Database
hsa-miR-22-3p lung disease MNDR Database
hsa-miR-22-3p lung small cell carcinoma MNDR Database
hsa-miR-22-3p lung squamous cell carcinoma MNDR Database
hsa-miR-22-3p lymphoma MNDR Database
hsa-miR-22-3p Lymphoma, T-Cell MNDR Database
hsa-miR-22-3p male infertility MNDR Database
hsa-miR-22-3p malignant glioma MNDR Database
hsa-miR-22-3p medulloblastoma MNDR Database
hsa-miR-22-3p melanoma MNDR Database
hsa-miR-22-3p meningioma MNDR Database
hsa-miR-22-3p Mesothelioma MNDR Database
hsa-miR-22-3p Mouth Neoplasms MNDR Database
hsa-miR-22-3p Moyamoya disease MNDR Database
hsa-miR-22-3p multiple myeloma MNDR Database
hsa-miR-22-3p multiple sclerosis MNDR Database
hsa-miR-22-3p Multiple Sclerosis, Chronic Progressive MNDR Database
hsa-miR-22-3p muscular dystrophy MNDR Database
hsa-miR-22-3p Muscular Disorders, Atrophic MNDR Database
hsa-miR-22-3p Myasthenia Gravis, Autoimmune, Experimental MNDR Database
hsa-miR-22-3p myelodysplastic syndrome MNDR Database
hsa-miR-22-3p myelodysplastic/myeloproliferative neoplasm MNDR Database
hsa-miR-22-3p myocardial infarction MNDR Database
hsa-miR-22-3p myopathy MNDR Database
hsa-miR-22-3p Myotonic Dystrophy MNDR Database
hsa-miR-22-3p nasopharynx carcinoma MNDR Database
hsa-miR-22-3p Neoplasms MNDR Database
hsa-miR-22-3p nephroblastoma MNDR Database
hsa-miR-22-3p neurodegenerative disease MNDR Database
hsa-miR-22-3p Neuroendocrine Tumors MNDR Database
hsa-miR-22-3p neuromyelitis optica MNDR Database
hsa-miR-22-3p Niemann-Pick disease MNDR Database
hsa-miR-22-3p Non-alcoholic Fatty Liver Disease MNDR Database
hsa-miR-22-3p oral squamous cell carcinoma MNDR Database
hsa-miR-22-3p osteosarcoma MNDR Database
hsa-miR-22-3p Ovarian Neoplasms MNDR Database
hsa-miR-22-3p oxyphilic adenoma MNDR Database
hsa-miR-22-3p pancreatic adenocarcinoma MNDR Database
hsa-miR-22-3p pancreatic cancer MNDR Database
hsa-miR-22-3p panic disorder MNDR Database
hsa-miR-22-3p papillary renal cell carcinoma MNDR Database
hsa-miR-22-3p Parkinson's disease MNDR Database
hsa-miR-22-3p Peripheral Nerve Injuries MNDR Database
hsa-miR-22-3p Peripheral Nervous System Diseases MNDR Database
hsa-miR-22-3p pituitary adenoma MNDR Database
hsa-miR-22-3p Precursor Cell Lymphoblastic Leukemia-Lymphoma MNDR Database
hsa-miR-22-3p progesterone-receptor negative breast cancer MNDR Database
hsa-miR-22-3p progesterone-receptor positive breast cancer MNDR Database
hsa-miR-22-3p prolactinoma MNDR Database
hsa-miR-22-3p prostate adenocarcinoma MNDR Database
hsa-miR-22-3p Prostatic Neoplasms MNDR Database
hsa-miR-22-3p psoriasis MNDR Database
hsa-miR-22-3p pulmonary emphysema MNDR Database
hsa-miR-22-3p rectum adenocarcinoma MNDR Database
hsa-miR-22-3p relapsing-remitting multiple sclerosis MNDR Database
hsa-miR-22-3p renal cell carcinoma MNDR Database
hsa-miR-22-3p renal clear cell carcinoma MNDR Database
hsa-miR-22-3p retinal degeneration MNDR Database
hsa-miR-22-3p retinoblastoma MNDR Database
hsa-miR-22-3p rhabdomyosarcoma MNDR Database
hsa-miR-22-3p Sarcopenia MNDR Database
hsa-miR-22-3p schizophrenia MNDR Database
hsa-miR-22-3p Seizures MNDR Database
hsa-miR-22-3p skin disease MNDR Database
hsa-miR-22-3p Sleep Deprivation MNDR Database
hsa-miR-22-3p squamous cell carcinoma MNDR Database
hsa-miR-22-3p stomach cancer MNDR Database
hsa-miR-22-3p Stroke, Lacunar MNDR Database
hsa-miR-22-3p systemic lupus erythematosus MNDR Database
hsa-miR-22-3p testicular cancer MNDR Database
hsa-miR-22-3p testicular germ cell cancer MNDR Database
hsa-miR-22-3p thoracic aortic aneurysm MNDR Database
hsa-miR-22-3p thrombocytopenia MNDR Database
hsa-miR-22-3p thyroid cancer MNDR Database
hsa-miR-22-3p thyroid carcinoma MNDR Database
hsa-miR-22-3p urinary bladder cancer MNDR Database
hsa-miR-22-3p Urinary Bladder Neoplasms MNDR Database
hsa-miR-22-3p uterine cancer MNDR Database
hsa-miR-22-3p uterine corpus endometrial carcinoma MNDR Database
hsa-miR-22-3p Uterine Cervical Neoplasms MNDR Database
hsa-miR-22-3p vascular disease MNDR Database
hsa-miR-22-3p viral hepatitis MNDR Database