Interaction: ncRI-40647672

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Interaction Profile

Interaction ID

ncRI-40647672

Interaction Molecules

hsa-miR-520d-3p -- UBE2B

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

miRanda and TargetScan with Ago CLIP data

Tags

Organism

Homo sapiens

Tissue or Cell Type

T-REx-293T;motor cortex

Experiment

AGO CLIP

Description

Conserved miRNAs target sites predicted by TargetScan and miRanda overlap with the AGO CLIP dataset

Molecule Profile

hsa-miR-520d-3p

⇔

UBE2B

Alias

-

Class

miRNA

miRBase id

MI0003164

Description

Homo sapiens miR-520d stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSG00000119048

Description

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys- 164'. May be involved in neurite outgrowth.

Reference Information
Pubmed ID 24389009 Journal Neuron
Title Transcriptome-wide discovery of microRNA binding sites in human brain.
Author Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL
Pubmed ID 29273203 Journal Journal of molecular biology
Title Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets.
Author Li Y, Estep JA, Karginov FV
Network View
Disease Annotation
Molecule Disease Data Source
hsa-miR-520d-3p acute myeloid leukemia MNDR Database
hsa-miR-520d-3p adenocarcinoma MNDR Database
hsa-miR-520d-3p Alzheimer's disease MNDR Database
hsa-miR-520d-3p arthritis MNDR Database
hsa-miR-520d-3p astrocytoma MNDR Database
hsa-miR-520d-3p autism spectrum disorder MNDR Database
hsa-miR-520d-3p autistic disorder MNDR Database
hsa-miR-520d-3p autosomal dominant disease MNDR Database
hsa-miR-520d-3p autosomal recessive disease MNDR Database
hsa-miR-520d-3p azoospermia MNDR Database
hsa-miR-520d-3p bone disease MNDR Database
hsa-miR-520d-3p brain disease MNDR Database
hsa-miR-520d-3p breast cancer MNDR Database
hsa-miR-520d-3p Breast Neoplasms MNDR Database
hsa-miR-520d-3p cancer MNDR Database
hsa-miR-520d-3p carcinoma MNDR Database
hsa-miR-520d-3p Carcinoma, Non-Small-Cell Lung MNDR Database
hsa-miR-520d-3p Chronic Pain MNDR Database
hsa-miR-520d-3p colon cancer MNDR Database
hsa-miR-520d-3p colorectal cancer MNDR Database
hsa-miR-520d-3p diabetes mellitus MNDR Database
hsa-miR-520d-3p dilated cardiomyopathy MNDR Database
hsa-miR-520d-3p embryonal cancer MNDR Database
hsa-miR-520d-3p endometriosis MNDR Database
hsa-miR-520d-3p Ependymoma MNDR Database
hsa-miR-520d-3p esophageal cancer MNDR Database
hsa-miR-520d-3p eye disease MNDR Database
hsa-miR-520d-3p familiar ovarian carcinoma MNDR Database
hsa-miR-520d-3p germ cell cancer MNDR Database
hsa-miR-520d-3p gout MNDR Database
hsa-miR-520d-3p heart disease MNDR Database
hsa-miR-520d-3p Heart Failure MNDR Database
hsa-miR-520d-3p hepatocellular carcinoma MNDR Database
hsa-miR-520d-3p hypersensitivity reaction type II disease MNDR Database
hsa-miR-520d-3p hypertension MNDR Database
hsa-miR-520d-3p intellectual disability MNDR Database
hsa-miR-520d-3p kidney cancer MNDR Database
hsa-miR-520d-3p kidney disease MNDR Database
hsa-miR-520d-3p leukemia MNDR Database
hsa-miR-520d-3p liposarcoma MNDR Database
hsa-miR-520d-3p Liver Neoplasms MNDR Database
hsa-miR-520d-3p lung adenocarcinoma MNDR Database
hsa-miR-520d-3p lung cancer MNDR Database
hsa-miR-520d-3p lung disease MNDR Database
hsa-miR-520d-3p lung squamous cell carcinoma MNDR Database
hsa-miR-520d-3p lymphoblastic leukemia MNDR Database
hsa-miR-520d-3p lymphoma MNDR Database
hsa-miR-520d-3p malignant glioma MNDR Database
hsa-miR-520d-3p melanoma MNDR Database
hsa-miR-520d-3p middle cerebral artery infarction MNDR Database
hsa-miR-520d-3p multiple myeloma MNDR Database
hsa-miR-520d-3p Multiple Sclerosis, Chronic Progressive MNDR Database
hsa-miR-520d-3p Myasthenia Gravis, Autoimmune, Experimental MNDR Database
hsa-miR-520d-3p myopathy MNDR Database
hsa-miR-520d-3p nasopharynx carcinoma MNDR Database
hsa-miR-520d-3p nephroblastoma MNDR Database
hsa-miR-520d-3p neuroblastoma MNDR Database
hsa-miR-520d-3p neurodegenerative disease MNDR Database
hsa-miR-520d-3p oral squamous cell carcinoma MNDR Database
hsa-miR-520d-3p Ovarian Neoplasms MNDR Database
hsa-miR-520d-3p pancreatic adenocarcinoma MNDR Database
hsa-miR-520d-3p pancreatic cancer MNDR Database
hsa-miR-520d-3p periodontitis MNDR Database
hsa-miR-520d-3p Peripheral Nervous System Diseases MNDR Database
hsa-miR-520d-3p progesterone-receptor negative breast cancer MNDR Database
hsa-miR-520d-3p Prostatic Neoplasms MNDR Database
hsa-miR-520d-3p pulmonary tuberculosis MNDR Database
hsa-miR-520d-3p relapsing-remitting multiple sclerosis MNDR Database
hsa-miR-520d-3p retinal degeneration MNDR Database
hsa-miR-520d-3p schizophrenia MNDR Database
hsa-miR-520d-3p skin disease MNDR Database
hsa-miR-520d-3p squamous cell carcinoma MNDR Database
hsa-miR-520d-3p stomach cancer MNDR Database
hsa-miR-520d-3p tonsil cancer MNDR Database
hsa-miR-520d-3p vascular disease MNDR Database