Interaction: ncRI-40646930

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Interaction Profile

Interaction ID

ncRI-40646930

Interaction Molecules

hsa-miR-513a-3p -- YAP1

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

miRanda with Ago CLIP data

Tags

Organism

Homo sapiens

Tissue or Cell Type

T-REx-293T

Experiment

AGO CLIP

Description

Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset

Molecule Profile

hsa-miR-513a-3p

⇔

YAP1

Alias

-

Class

miRNA

miRBase id

MI0003191

Description

Homo sapiens miR-513a-1 stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSG00000137693

Description

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750).

Reference Information
Pubmed ID 29273203 Journal Journal of molecular biology
Title Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets.
Author Li Y, Estep JA, Karginov FV
Network View
Disease Annotation
Molecule Disease Data Source
hsa-miR-513a-3p adrenocortical carcinoma MNDR Database
hsa-miR-513a-3p Adrenocortical Carcinoma MNDR Database
hsa-miR-513a-3p Alzheimer's disease MNDR Database
hsa-miR-513a-3p arthritis MNDR Database
hsa-miR-513a-3p asthma MNDR Database
hsa-miR-513a-3p autosomal recessive disease MNDR Database
hsa-miR-513a-3p B-cell lymphoma MNDR Database
hsa-miR-513a-3p biliary tract cancer MNDR Database
hsa-miR-513a-3p bone disease MNDR Database
hsa-miR-513a-3p brain disease MNDR Database
hsa-miR-513a-3p breast cancer MNDR Database
hsa-miR-513a-3p Breast Neoplasms MNDR Database
hsa-miR-513a-3p cancer MNDR Database
hsa-miR-513a-3p carcinoma MNDR Database
hsa-miR-513a-3p cholangiocarcinoma MNDR Database
hsa-miR-513a-3p colon cancer MNDR Database
hsa-miR-513a-3p colorectal cancer MNDR Database
hsa-miR-513a-3p diabetes mellitus MNDR Database
hsa-miR-513a-3p Down syndrome MNDR Database
hsa-miR-513a-3p esophageal cancer MNDR Database
hsa-miR-513a-3p eye disease MNDR Database
hsa-miR-513a-3p familiar ovarian carcinoma MNDR Database
hsa-miR-513a-3p heart disease MNDR Database
hsa-miR-513a-3p hepatocellular carcinoma MNDR Database
hsa-miR-513a-3p Her2-receptor positive breast cancer MNDR Database
hsa-miR-513a-3p Hodgkin's lymphoma MNDR Database
hsa-miR-513a-3p hypersensitivity reaction type II disease MNDR Database
hsa-miR-513a-3p intellectual disability MNDR Database
hsa-miR-513a-3p intrahepatic cholangiocarcinoma MNDR Database
hsa-miR-513a-3p kidney disease MNDR Database
hsa-miR-513a-3p leukemia MNDR Database
hsa-miR-513a-3p liposarcoma MNDR Database
hsa-miR-513a-3p liver cirrhosis MNDR Database
hsa-miR-513a-3p Liver Neoplasms MNDR Database
hsa-miR-513a-3p lung adenocarcinoma MNDR Database
hsa-miR-513a-3p lung cancer MNDR Database
hsa-miR-513a-3p lung disease MNDR Database
hsa-miR-513a-3p lung squamous cell carcinoma MNDR Database
hsa-miR-513a-3p lupus nephritis MNDR Database
hsa-miR-513a-3p lymphoma MNDR Database
hsa-miR-513a-3p male infertility MNDR Database
hsa-miR-513a-3p malignant glioma MNDR Database
hsa-miR-513a-3p melanoma MNDR Database
hsa-miR-513a-3p multiple myeloma MNDR Database
hsa-miR-513a-3p nephroblastoma MNDR Database
hsa-miR-513a-3p neurodegenerative disease MNDR Database
hsa-miR-513a-3p non-Hodgkin lymphoma MNDR Database
hsa-miR-513a-3p oral squamous cell carcinoma MNDR Database
hsa-miR-513a-3p osteosarcoma MNDR Database
hsa-miR-513a-3p ovarian clear cell carcinoma MNDR Database
hsa-miR-513a-3p Ovarian Neoplasms MNDR Database
hsa-miR-513a-3p pancreatic adenocarcinoma MNDR Database
hsa-miR-513a-3p pancreatic cancer MNDR Database
hsa-miR-513a-3p pancreatic ductal adenocarcinoma MNDR Database
hsa-miR-513a-3p pituitary adenoma MNDR Database
hsa-miR-513a-3p progesterone-receptor negative breast cancer MNDR Database
hsa-miR-513a-3p progesterone-receptor positive breast cancer MNDR Database
hsa-miR-513a-3p Prostatic Neoplasms MNDR Database
hsa-miR-513a-3p retinoblastoma MNDR Database
hsa-miR-513a-3p schizophrenia MNDR Database
hsa-miR-513a-3p skin disease MNDR Database
hsa-miR-513a-3p skin melanoma MNDR Database
hsa-miR-513a-3p stomach cancer MNDR Database
hsa-miR-513a-3p Stroke, Lacunar MNDR Database
hsa-miR-513a-3p tonsil cancer MNDR Database
hsa-miR-513a-3p urinary bladder cancer MNDR Database
hsa-miR-513a-3p vascular disease MNDR Database
hsa-miR-513a-3p coloboma, ocular, autosomal dominant eDGAR Database
hsa-miR-513a-3p coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation eDGAR Database