Interaction ID
ncRI-40643084
Interaction Molecules
hsa-miR-3180-3p -- DNAJB12
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
T-REx-293T;HEK293S
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSG00000148719
Description
Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:21150129, PubMed:21148293). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912).
| Pubmed ID | 23824327 | Journal | Genes & development |
|---|---|---|---|
| Title | Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates. | ||
| Author | Karginov FV, Hannon GJ | ||
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-3180-3p | amyotrophic lateral sclerosis | MNDR Database |
| hsa-miR-3180-3p | cancer | MNDR Database |
| hsa-miR-3180-3p | cholangiocarcinoma | MNDR Database |
| hsa-miR-3180-3p | chordoma | MNDR Database |
| hsa-miR-3180-3p | colon cancer | MNDR Database |
| hsa-miR-3180-3p | colorectal cancer | MNDR Database |
| hsa-miR-3180-3p | Down syndrome | MNDR Database |
| hsa-miR-3180-3p | embryonal cancer | MNDR Database |
| hsa-miR-3180-3p | esophageal cancer | MNDR Database |
| hsa-miR-3180-3p | hepatocellular carcinoma | MNDR Database |
| hsa-miR-3180-3p | Liver Neoplasms | MNDR Database |
| hsa-miR-3180-3p | malignant glioma | MNDR Database |
| hsa-miR-3180-3p | Moyamoya disease | MNDR Database |
| hsa-miR-3180-3p | nephroblastoma | MNDR Database |
| hsa-miR-3180-3p | Ovarian Neoplasms | MNDR Database |
| hsa-miR-3180-3p | progressive supranuclear palsy | MNDR Database |
| hsa-miR-3180-3p | stomach cancer | MNDR Database |
| hsa-miR-3180-3p | Subarachnoid Hemorrhage, Traumatic | MNDR Database |
| hsa-miR-3180-3p | vascular disease | MNDR Database |