Interaction Profile
Interaction ID
ncRI-40643002
Interaction Molecules
hsa-miR-152-3p -- ATP2A2
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda and TargetScan with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
T-REx-293T;Left ventricle;motor cortex
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by TargetScan and miRanda overlap with the AGO CLIP dataset
Molecule Profile
Alias
-
Class
mRNA
Ensembl id
ENSG00000174437
Description
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle (PubMed:16402920). Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11- induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (By similarity).
Reference Information
| Pubmed ID | 24389009 | Journal | Neuron |
|---|---|---|---|
| Title | Transcriptome-wide discovery of microRNA binding sites in human brain. | ||
| Author | Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL | ||
| Pubmed ID | 27418678 | Journal | Nucleic acids research |
|---|---|---|---|
| Title | Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP. | ||
| Author | Spengler RM, Zhang X, Cheng C, McLendon JM, Skeie JM, Johnson FL, Davidson BL, Boudreau RL | ||
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
Network View
Disease Annotation
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-152-3p | acute myeloid leukemia | MNDR Database |
| hsa-miR-152-3p | adenocarcinoma | MNDR Database |
| hsa-miR-152-3p | Alzheimer's disease | MNDR Database |
| hsa-miR-152-3p | amyotrophic lateral sclerosis | MNDR Database |
| hsa-miR-152-3p | anxiety disorder | MNDR Database |
| hsa-miR-152-3p | arthritis | MNDR Database |
| hsa-miR-152-3p | asthma | MNDR Database |
| hsa-miR-152-3p | atherosclerosis | MNDR Database |
| hsa-miR-152-3p | autosomal recessive disease | MNDR Database |
| hsa-miR-152-3p | autosomal recessive limb-girdle muscular dystrophy type 2A | MNDR Database |
| hsa-miR-152-3p | autosomal recessive limb-girdle muscular dystrophy type 2B | MNDR Database |
| hsa-miR-152-3p | B-cell lymphoma | MNDR Database |
| hsa-miR-152-3p | bladder urothelial carcinoma | MNDR Database |
| hsa-miR-152-3p | bone disease | MNDR Database |
| hsa-miR-152-3p | brain cancer | MNDR Database |
| hsa-miR-152-3p | brain disease | MNDR Database |
| hsa-miR-152-3p | breast cancer | MNDR Database |
| hsa-miR-152-3p | Breast Neoplasms | MNDR Database |
| hsa-miR-152-3p | cancer | MNDR Database |
| hsa-miR-152-3p | carcinoma | MNDR Database |
| hsa-miR-152-3p | Carcinoma, Ductal, Breast | MNDR Database |
| hsa-miR-152-3p | Carcinoma, Non-Small-Cell Lung | MNDR Database |
| hsa-miR-152-3p | Carcinoma, Renal Cell | MNDR Database |
| hsa-miR-152-3p | cervical adenocarcinoma | MNDR Database |
| hsa-miR-152-3p | cholangiocarcinoma | MNDR Database |
| hsa-miR-152-3p | chronic fatigue syndrome | MNDR Database |
| hsa-miR-152-3p | chronic lymphocytic leukemia | MNDR Database |
| hsa-miR-152-3p | colon adenocarcinoma | MNDR Database |
| hsa-miR-152-3p | colon cancer | MNDR Database |
| hsa-miR-152-3p | colorectal cancer | MNDR Database |
| hsa-miR-152-3p | dengue disease | MNDR Database |
| hsa-miR-152-3p | diabetes mellitus | MNDR Database |
| hsa-miR-152-3p | endometrial cancer | MNDR Database |
| hsa-miR-152-3p | esophageal cancer | MNDR Database |
| hsa-miR-152-3p | eye disease | MNDR Database |
| hsa-miR-152-3p | familiar ovarian carcinoma | MNDR Database |
| hsa-miR-152-3p | gastric adenocarcinoma | MNDR Database |
| hsa-miR-152-3p | gastrointestinal system cancer | MNDR Database |
| hsa-miR-152-3p | Gaucher's disease | MNDR Database |
| hsa-miR-152-3p | Glioblastoma | MNDR Database |
| hsa-miR-152-3p | head and neck cancer | MNDR Database |
| hsa-miR-152-3p | head and neck squamous cell carcinoma | MNDR Database |
| hsa-miR-152-3p | heart disease | MNDR Database |
| hsa-miR-152-3p | hematologic cancer | MNDR Database |
| hsa-miR-152-3p | hepatocellular carcinoma | MNDR Database |
| hsa-miR-152-3p | Her2-receptor positive breast cancer | MNDR Database |
| hsa-miR-152-3p | Hodgkin's lymphoma | MNDR Database |
| hsa-miR-152-3p | hypertension | MNDR Database |
| hsa-miR-152-3p | intellectual disability | MNDR Database |
| hsa-miR-152-3p | kidney disease | MNDR Database |
| hsa-miR-152-3p | leukemia | MNDR Database |
| hsa-miR-152-3p | Liver Neoplasms | MNDR Database |
| hsa-miR-152-3p | lung adenocarcinoma | MNDR Database |
| hsa-miR-152-3p | lung cancer | MNDR Database |
| hsa-miR-152-3p | lung disease | MNDR Database |
| hsa-miR-152-3p | lung small cell carcinoma | MNDR Database |
| hsa-miR-152-3p | lung squamous cell carcinoma | MNDR Database |
| hsa-miR-152-3p | lymphoma | MNDR Database |
| hsa-miR-152-3p | malignant glioma | MNDR Database |
| hsa-miR-152-3p | melanoma | MNDR Database |
| hsa-miR-152-3p | meningioma | MNDR Database |
| hsa-miR-152-3p | multiple myeloma | MNDR Database |
| hsa-miR-152-3p | Multiple Sclerosis, Chronic Progressive | MNDR Database |
| hsa-miR-152-3p | myopathy | MNDR Database |
| hsa-miR-152-3p | nasopharynx carcinoma | MNDR Database |
| hsa-miR-152-3p | nemaline myopathy | MNDR Database |
| hsa-miR-152-3p | nephroblastoma | MNDR Database |
| hsa-miR-152-3p | neuroblastoma | MNDR Database |
| hsa-miR-152-3p | neurodegenerative disease | MNDR Database |
| hsa-miR-152-3p | neuromyelitis optica | MNDR Database |
| hsa-miR-152-3p | Niemann-Pick disease | MNDR Database |
| hsa-miR-152-3p | oral squamous cell carcinoma | MNDR Database |
| hsa-miR-152-3p | osteosarcoma | MNDR Database |
| hsa-miR-152-3p | ovarian carcinoma | MNDR Database |
| hsa-miR-152-3p | Ovarian epithelial cancer | MNDR Database |
| hsa-miR-152-3p | Ovarian Neoplasms | MNDR Database |
| hsa-miR-152-3p | pancreatic adenocarcinoma | MNDR Database |
| hsa-miR-152-3p | pancreatic cancer | MNDR Database |
| hsa-miR-152-3p | papillary renal cell carcinoma | MNDR Database |
| hsa-miR-152-3p | Peripheral Nervous System Diseases | MNDR Database |
| hsa-miR-152-3p | Precursor Cell Lymphoblastic Leukemia-Lymphoma | MNDR Database |
| hsa-miR-152-3p | pre-eclampsia | MNDR Database |
| hsa-miR-152-3p | progesterone-receptor negative breast cancer | MNDR Database |
| hsa-miR-152-3p | progesterone-receptor positive breast cancer | MNDR Database |
| hsa-miR-152-3p | prostate adenocarcinoma | MNDR Database |
| hsa-miR-152-3p | Prostatic Neoplasms | MNDR Database |
| hsa-miR-152-3p | rectum adenocarcinoma | MNDR Database |
| hsa-miR-152-3p | relapsing-remitting multiple sclerosis | MNDR Database |
| hsa-miR-152-3p | renal clear cell carcinoma | MNDR Database |
| hsa-miR-152-3p | rheumatoid arthritis | MNDR Database |
| hsa-miR-152-3p | schizophrenia | MNDR Database |
| hsa-miR-152-3p | skin melanoma | MNDR Database |
| hsa-miR-152-3p | stomach cancer | MNDR Database |
| hsa-miR-152-3p | Subarachnoid Hemorrhage, Traumatic | MNDR Database |
| hsa-miR-152-3p | testicular germ cell cancer | MNDR Database |
| hsa-miR-152-3p | thyroid cancer | MNDR Database |
| hsa-miR-152-3p | thyroid carcinoma | MNDR Database |
| hsa-miR-152-3p | type 2 diabetes mellitus | MNDR Database |
| hsa-miR-152-3p | urinary bladder cancer | MNDR Database |
| hsa-miR-152-3p | uterine corpus endometrial carcinoma | MNDR Database |
| hsa-miR-152-3p | vascular disease | MNDR Database |
| hsa-miR-152-3p | acrokeratosis verruciformis | eDGAR Database |
| hsa-miR-152-3p | darier-white disease | eDGAR Database |