Interaction ID
ncRI-40641232
Interaction Molecules
hsa-miR-497-3p -- RORA
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
TargetScan with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
T-REx-293T;HEK293S
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by TargetScan overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSG00000069667
Description
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development (PubMed:29656859). Regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction. Regulates the circadian expression of several clock genes, including CLOCK, ARNTL/BMAL1, NPAS2 and CRY1. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1. Induces a rhythmic expression of some of these genes. In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism. Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC and PCK1. In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms. May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding. Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A. May inhibit cell growth in response to cellular stress. May exert an anti- inflammatory role by inducing CHUK expression and inhibiting NF- kappa-B signaling.
| Pubmed ID | 23824327 | Journal | Genes & development |
|---|---|---|---|
| Title | Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates. | ||
| Author | Karginov FV, Hannon GJ | ||
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-497-3p | adrenocortical carcinoma | MNDR Database |
| hsa-miR-497-3p | Adrenocortical Carcinoma | MNDR Database |
| hsa-miR-497-3p | AIDS Dementia Complex | MNDR Database |
| hsa-miR-497-3p | Alzheimer's disease | MNDR Database |
| hsa-miR-497-3p | arthritis | MNDR Database |
| hsa-miR-497-3p | astrocytoma | MNDR Database |
| hsa-miR-497-3p | atherosclerosis | MNDR Database |
| hsa-miR-497-3p | autosomal recessive disease | MNDR Database |
| hsa-miR-497-3p | autosomal recessive limb-girdle muscular dystrophy type 2A | MNDR Database |
| hsa-miR-497-3p | autosomal recessive limb-girdle muscular dystrophy type 2B | MNDR Database |
| hsa-miR-497-3p | Barrett's adenocarcinoma | MNDR Database |
| hsa-miR-497-3p | bladder urothelial carcinoma | MNDR Database |
| hsa-miR-497-3p | bone disease | MNDR Database |
| hsa-miR-497-3p | brain disease | MNDR Database |
| hsa-miR-497-3p | breast cancer | MNDR Database |
| hsa-miR-497-3p | Breast Neoplasms | MNDR Database |
| hsa-miR-497-3p | Burkitt lymphoma | MNDR Database |
| hsa-miR-497-3p | cancer | MNDR Database |
| hsa-miR-497-3p | carcinoma | MNDR Database |
| hsa-miR-497-3p | Carcinoma, Ductal, Breast | MNDR Database |
| hsa-miR-497-3p | Carcinoma, Non-Small-Cell Lung | MNDR Database |
| hsa-miR-497-3p | Carcinoma, Renal Cell | MNDR Database |
| hsa-miR-497-3p | cervical squamous cell carcinoma | MNDR Database |
| hsa-miR-497-3p | cholangiocarcinoma | MNDR Database |
| hsa-miR-497-3p | chordoma | MNDR Database |
| hsa-miR-497-3p | chromophobe renal cell carcinoma | MNDR Database |
| hsa-miR-497-3p | colon adenocarcinoma | MNDR Database |
| hsa-miR-497-3p | colon cancer | MNDR Database |
| hsa-miR-497-3p | colorectal cancer | MNDR Database |
| hsa-miR-497-3p | connective tissue disease | MNDR Database |
| hsa-miR-497-3p | diabetes mellitus | MNDR Database |
| hsa-miR-497-3p | diffuse large B-cell lymphoma | MNDR Database |
| hsa-miR-497-3p | dilated cardiomyopathy | MNDR Database |
| hsa-miR-497-3p | Duke A | MNDR Database |
| hsa-miR-497-3p | Duke C | MNDR Database |
| hsa-miR-497-3p | embryonal cancer | MNDR Database |
| hsa-miR-497-3p | esophageal cancer | MNDR Database |
| hsa-miR-497-3p | esophageal carcinoma | MNDR Database |
| hsa-miR-497-3p | eye disease | MNDR Database |
| hsa-miR-497-3p | familiar ovarian carcinoma | MNDR Database |
| hsa-miR-497-3p | gastric adenocarcinoma | MNDR Database |
| hsa-miR-497-3p | gastrointestinal system cancer | MNDR Database |
| hsa-miR-497-3p | gastrointestinal system disease | MNDR Database |
| hsa-miR-497-3p | Glioblastoma | MNDR Database |
| hsa-miR-497-3p | head and neck cancer | MNDR Database |
| hsa-miR-497-3p | head and neck squamous cell carcinoma | MNDR Database |
| hsa-miR-497-3p | heart disease | MNDR Database |
| hsa-miR-497-3p | Heart Failure | MNDR Database |
| hsa-miR-497-3p | hepatocellular carcinoma | MNDR Database |
| hsa-miR-497-3p | Her2-receptor positive breast cancer | MNDR Database |
| hsa-miR-497-3p | Hodgkin's lymphoma | MNDR Database |
| hsa-miR-497-3p | hypersensitivity reaction type II disease | MNDR Database |
| hsa-miR-497-3p | hypertension | MNDR Database |
| hsa-miR-497-3p | intellectual disability | MNDR Database |
| hsa-miR-497-3p | intestinal disease | MNDR Database |
| hsa-miR-497-3p | intracranial aneurysm | MNDR Database |
| hsa-miR-497-3p | invasive ductal carcinoma | MNDR Database |
| hsa-miR-497-3p | kidney cancer | MNDR Database |
| hsa-miR-497-3p | kidney disease | MNDR Database |
| hsa-miR-497-3p | large cell carcinoma | MNDR Database |
| hsa-miR-497-3p | large cell neuroendocrine cancer | MNDR Database |
| hsa-miR-497-3p | leukemia | MNDR Database |
| hsa-miR-497-3p | lung adenocarcinoma | MNDR Database |
| hsa-miR-497-3p | lung cancer | MNDR Database |
| hsa-miR-497-3p | lung disease | MNDR Database |
| hsa-miR-497-3p | lung small cell carcinoma | MNDR Database |
| hsa-miR-497-3p | lung squamous cell carcinoma | MNDR Database |
| hsa-miR-497-3p | lupus erythematosus | MNDR Database |
| hsa-miR-497-3p | lymphoblastic leukemia | MNDR Database |
| hsa-miR-497-3p | lymphoma | MNDR Database |
| hsa-miR-497-3p | malignant glioma | MNDR Database |
| hsa-miR-497-3p | medulloblastoma | MNDR Database |
| hsa-miR-497-3p | melanoma | MNDR Database |
| hsa-miR-497-3p | meningioma | MNDR Database |
| hsa-miR-497-3p | Mesothelioma | MNDR Database |
| hsa-miR-497-3p | Multiple Sclerosis, Chronic Progressive | MNDR Database |
| hsa-miR-497-3p | muscular disease | MNDR Database |
| hsa-miR-497-3p | Muscular Disorders, Atrophic | MNDR Database |
| hsa-miR-497-3p | myopathy | MNDR Database |
| hsa-miR-497-3p | nasopharynx carcinoma | MNDR Database |
| hsa-miR-497-3p | Neoplasms | MNDR Database |
| hsa-miR-497-3p | nephroblastoma | MNDR Database |
| hsa-miR-497-3p | neuroblastoma | MNDR Database |
| hsa-miR-497-3p | neurodegenerative disease | MNDR Database |
| hsa-miR-497-3p | Neuroendocrine Tumors | MNDR Database |
| hsa-miR-497-3p | oral squamous cell carcinoma | MNDR Database |
| hsa-miR-497-3p | osteosarcoma | MNDR Database |
| hsa-miR-497-3p | Ovarian Neoplasms | MNDR Database |
| hsa-miR-497-3p | pancreatic adenocarcinoma | MNDR Database |
| hsa-miR-497-3p | pancreatic cancer | MNDR Database |
| hsa-miR-497-3p | Pancreatitis, Chronic | MNDR Database |
| hsa-miR-497-3p | papillary renal cell carcinoma | MNDR Database |
| hsa-miR-497-3p | Peripheral Nervous System Diseases | MNDR Database |
| hsa-miR-497-3p | pituitary adenoma | MNDR Database |
| hsa-miR-497-3p | progesterone-receptor negative breast cancer | MNDR Database |
| hsa-miR-497-3p | progesterone-receptor positive breast cancer | MNDR Database |
| hsa-miR-497-3p | prostate adenocarcinoma | MNDR Database |
| hsa-miR-497-3p | Prostatic Neoplasms | MNDR Database |
| hsa-miR-497-3p | rectum adenocarcinoma | MNDR Database |
| hsa-miR-497-3p | relapsing-remitting multiple sclerosis | MNDR Database |
| hsa-miR-497-3p | renal cell carcinoma | MNDR Database |
| hsa-miR-497-3p | renal clear cell carcinoma | MNDR Database |
| hsa-miR-497-3p | retinoblastoma | MNDR Database |
| hsa-miR-497-3p | sarcoma | MNDR Database |
| hsa-miR-497-3p | schizophrenia | MNDR Database |
| hsa-miR-497-3p | Seizures | MNDR Database |
| hsa-miR-497-3p | skin disease | MNDR Database |
| hsa-miR-497-3p | squamous cell carcinoma | MNDR Database |
| hsa-miR-497-3p | stomach cancer | MNDR Database |
| hsa-miR-497-3p | Stroke | MNDR Database |
| hsa-miR-497-3p | temporal lobe epilepsy | MNDR Database |
| hsa-miR-497-3p | testicular germ cell cancer | MNDR Database |
| hsa-miR-497-3p | thyroid cancer | MNDR Database |
| hsa-miR-497-3p | thyroid carcinoma | MNDR Database |
| hsa-miR-497-3p | urinary bladder cancer | MNDR Database |
| hsa-miR-497-3p | uterine corpus endometrial carcinoma | MNDR Database |
| hsa-miR-497-3p | Uterine Cervical Neoplasms | MNDR Database |
| hsa-miR-497-3p | vascular disease | MNDR Database |