Interaction Profile
Interaction ID
ncRI-40640697
Interaction Molecules
hsa-miR-138-2-3p -- IGF2BP3
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
T-REx-293T;tumor
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Molecule Profile
Alias
-
Class
mRNA
Ensembl id
ENSG00000136231
Description
RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta- actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.
Reference Information
| Pubmed ID | 28735896 | Journal | Molecular cell |
|---|---|---|---|
| Title | Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer. | ||
| Author | Luna JM, Barajas JM, Teng KY, Sun HL, Moore MJ, Rice CM, Darnell RB, Ghoshal K | ||
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
Network View
Disease Annotation
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-138-2-3p | Alzheimer's disease | MNDR Database |
| hsa-miR-138-2-3p | amyotrophic lateral sclerosis | MNDR Database |
| hsa-miR-138-2-3p | anencephaly | MNDR Database |
| hsa-miR-138-2-3p | arthritis | MNDR Database |
| hsa-miR-138-2-3p | astrocytoma | MNDR Database |
| hsa-miR-138-2-3p | autosomal recessive disease | MNDR Database |
| hsa-miR-138-2-3p | B-cell lymphoma | MNDR Database |
| hsa-miR-138-2-3p | bladder urothelial carcinoma | MNDR Database |
| hsa-miR-138-2-3p | bone disease | MNDR Database |
| hsa-miR-138-2-3p | brain disease | MNDR Database |
| hsa-miR-138-2-3p | breast cancer | MNDR Database |
| hsa-miR-138-2-3p | Breast Neoplasms | MNDR Database |
| hsa-miR-138-2-3p | Burkitt lymphoma | MNDR Database |
| hsa-miR-138-2-3p | cancer | MNDR Database |
| hsa-miR-138-2-3p | carcinoma | MNDR Database |
| hsa-miR-138-2-3p | Carcinoma, Non-Small-Cell Lung | MNDR Database |
| hsa-miR-138-2-3p | chronic lymphocytic leukemia | MNDR Database |
| hsa-miR-138-2-3p | chronic myeloid leukemia | MNDR Database |
| hsa-miR-138-2-3p | colon cancer | MNDR Database |
| hsa-miR-138-2-3p | colorectal cancer | MNDR Database |
| hsa-miR-138-2-3p | connective tissue disease | MNDR Database |
| hsa-miR-138-2-3p | cystic nephroma | MNDR Database |
| hsa-miR-138-2-3p | diabetes mellitus | MNDR Database |
| hsa-miR-138-2-3p | esophageal cancer | MNDR Database |
| hsa-miR-138-2-3p | eye disease | MNDR Database |
| hsa-miR-138-2-3p | familiar ovarian carcinoma | MNDR Database |
| hsa-miR-138-2-3p | fragile X syndrome | MNDR Database |
| hsa-miR-138-2-3p | gallbladder carcinoma | MNDR Database |
| hsa-miR-138-2-3p | gastric adenocarcinoma | MNDR Database |
| hsa-miR-138-2-3p | gastric lymphoma | MNDR Database |
| hsa-miR-138-2-3p | Glioblastoma | MNDR Database |
| hsa-miR-138-2-3p | head and neck cancer | MNDR Database |
| hsa-miR-138-2-3p | head and neck squamous cell carcinoma | MNDR Database |
| hsa-miR-138-2-3p | heart disease | MNDR Database |
| hsa-miR-138-2-3p | Heart Failure | MNDR Database |
| hsa-miR-138-2-3p | hepatocellular carcinoma | MNDR Database |
| hsa-miR-138-2-3p | Her2-receptor positive breast cancer | MNDR Database |
| hsa-miR-138-2-3p | HIV | MNDR Database |
| hsa-miR-138-2-3p | Huntington's disease | MNDR Database |
| hsa-miR-138-2-3p | hypersensitivity reaction type II disease | MNDR Database |
| hsa-miR-138-2-3p | hypertension | MNDR Database |
| hsa-miR-138-2-3p | intellectual disability | MNDR Database |
| hsa-miR-138-2-3p | kidney disease | MNDR Database |
| hsa-miR-138-2-3p | large cell neuroendocrine cancer | MNDR Database |
| hsa-miR-138-2-3p | leukemia | MNDR Database |
| hsa-miR-138-2-3p | liver disease | MNDR Database |
| hsa-miR-138-2-3p | lung adenocarcinoma | MNDR Database |
| hsa-miR-138-2-3p | lung cancer | MNDR Database |
| hsa-miR-138-2-3p | lung disease | MNDR Database |
| hsa-miR-138-2-3p | lung small cell carcinoma | MNDR Database |
| hsa-miR-138-2-3p | lung squamous cell carcinoma | MNDR Database |
| hsa-miR-138-2-3p | Lymphoblastoid | MNDR Database |
| hsa-miR-138-2-3p | lymphoma | MNDR Database |
| hsa-miR-138-2-3p | Lymphoma, Non-Hodgkin | MNDR Database |
| hsa-miR-138-2-3p | malignant glioma | MNDR Database |
| hsa-miR-138-2-3p | malignant pleural mesothelioma | MNDR Database |
| hsa-miR-138-2-3p | medulloblastoma | MNDR Database |
| hsa-miR-138-2-3p | medulloepithelioma | MNDR Database |
| hsa-miR-138-2-3p | melanoma | MNDR Database |
| hsa-miR-138-2-3p | Multiple Sclerosis, Chronic Progressive | MNDR Database |
| hsa-miR-138-2-3p | myeloid leukemia | MNDR Database |
| hsa-miR-138-2-3p | Myocardial Ischemia | MNDR Database |
| hsa-miR-138-2-3p | myopathy | MNDR Database |
| hsa-miR-138-2-3p | nasopharynx carcinoma | MNDR Database |
| hsa-miR-138-2-3p | Neoplasms | MNDR Database |
| hsa-miR-138-2-3p | nephroblastoma | MNDR Database |
| hsa-miR-138-2-3p | neuroblastoma | MNDR Database |
| hsa-miR-138-2-3p | neurodegenerative disease | MNDR Database |
| hsa-miR-138-2-3p | Neuroendocrine Tumors | MNDR Database |
| hsa-miR-138-2-3p | non-Hodgkin lymphoma | MNDR Database |
| hsa-miR-138-2-3p | oral squamous cell carcinoma | MNDR Database |
| hsa-miR-138-2-3p | osteoarthritis | MNDR Database |
| hsa-miR-138-2-3p | osteosarcoma | MNDR Database |
| hsa-miR-138-2-3p | ovarian carcinoma | MNDR Database |
| hsa-miR-138-2-3p | ovarian clear cell carcinoma | MNDR Database |
| hsa-miR-138-2-3p | Ovarian Neoplasms | MNDR Database |
| hsa-miR-138-2-3p | pancreatic adenocarcinoma | MNDR Database |
| hsa-miR-138-2-3p | pancreatic cancer | MNDR Database |
| hsa-miR-138-2-3p | panic disorder | MNDR Database |
| hsa-miR-138-2-3p | papillary thyroid carcinoma | MNDR Database |
| hsa-miR-138-2-3p | Parkinson's disease | MNDR Database |
| hsa-miR-138-2-3p | Peripheral Nervous System Diseases | MNDR Database |
| hsa-miR-138-2-3p | pituitary adenoma | MNDR Database |
| hsa-miR-138-2-3p | pleuropulmonary blastoma | MNDR Database |
| hsa-miR-138-2-3p | Precursor Cell Lymphoblastic Leukemia-Lymphoma | MNDR Database |
| hsa-miR-138-2-3p | progesterone-receptor positive breast cancer | MNDR Database |
| hsa-miR-138-2-3p | Prostatic Neoplasms | MNDR Database |
| hsa-miR-138-2-3p | psoriasis | MNDR Database |
| hsa-miR-138-2-3p | relapsing-remitting multiple sclerosis | MNDR Database |
| hsa-miR-138-2-3p | renal cell carcinoma | MNDR Database |
| hsa-miR-138-2-3p | renal clear cell carcinoma | MNDR Database |
| hsa-miR-138-2-3p | retinoblastoma | MNDR Database |
| hsa-miR-138-2-3p | Sertoli-Leydig cell tumor | MNDR Database |
| hsa-miR-138-2-3p | skin disease | MNDR Database |
| hsa-miR-138-2-3p | skin melanoma | MNDR Database |
| hsa-miR-138-2-3p | Sleep Deprivation | MNDR Database |
| hsa-miR-138-2-3p | squamous cell carcinoma | MNDR Database |
| hsa-miR-138-2-3p | stomach cancer | MNDR Database |
| hsa-miR-138-2-3p | T-cell leukemia | MNDR Database |
| hsa-miR-138-2-3p | temporal lobe epilepsy | MNDR Database |
| hsa-miR-138-2-3p | thyroid cancer | MNDR Database |
| hsa-miR-138-2-3p | thyroid carcinoma | MNDR Database |
| hsa-miR-138-2-3p | thyroid Hurthle cell carcinoma | MNDR Database |
| hsa-miR-138-2-3p | Thyroid Carcinoma, Anaplastic | MNDR Database |
| hsa-miR-138-2-3p | type 2 diabetes mellitus | MNDR Database |
| hsa-miR-138-2-3p | Urinary Bladder Neoplasms | MNDR Database |
| hsa-miR-138-2-3p | Uterine Cervical Neoplasms | MNDR Database |
| hsa-miR-138-2-3p | vascular disease | MNDR Database |
| hsa-miR-138-2-3p | X-linked disease | MNDR Database |