Interaction ID
ncRI-40640390
Interaction Molecules
hsa-miR-3151-5p -- STARD3
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
T-REx-293T
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSG00000131748
Description
Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544).
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-3151-5p | acute myeloid leukemia | MNDR Database |
| hsa-miR-3151-5p | breast cancer | MNDR Database |
| hsa-miR-3151-5p | cholangiocarcinoma | MNDR Database |
| hsa-miR-3151-5p | colon cancer | MNDR Database |
| hsa-miR-3151-5p | colorectal cancer | MNDR Database |
| hsa-miR-3151-5p | esophageal cancer | MNDR Database |
| hsa-miR-3151-5p | Liver Neoplasms | MNDR Database |
| hsa-miR-3151-5p | pancreatic cancer | MNDR Database |
| hsa-miR-3151-5p | progressive supranuclear palsy | MNDR Database |
| hsa-miR-3151-5p | stomach cancer | MNDR Database |
| hsa-miR-3151-5p | thyroid cancer | MNDR Database |