Interaction: ncRI-40640352

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Interaction Profile

Interaction ID

ncRI-40640352

Interaction Molecules

hsa-miR-381-3p -- YTHDC1

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

TargetScan with Ago CLIP data

Tags

Organism

Homo sapiens

Tissue or Cell Type

T-REx-293T;Cingulategyrus

Experiment

AGO CLIP

Description

Conserved miRNAs target sites predicted by TargetScan and miRanda overlap with the AGO CLIP dataset

Molecule Profile

hsa-miR-381-3p

⇔

YTHDC1

Alias

-

Class

miRNA

miRBase id

MI0000789

Description

Homo sapiens miR-381 stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSG00000083896

Description

Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Involved in S- adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity).

Reference Information
Pubmed ID 24389009 Journal Neuron
Title Transcriptome-wide discovery of microRNA binding sites in human brain.
Author Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL
Pubmed ID 29273203 Journal Journal of molecular biology
Title Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets.
Author Li Y, Estep JA, Karginov FV
Network View
Disease Annotation
Molecule Disease Data Source
hsa-miR-381-3p acromegaly MNDR Database
hsa-miR-381-3p adrenocortical carcinoma MNDR Database
hsa-miR-381-3p Alzheimer's disease MNDR Database
hsa-miR-381-3p amyotrophic lateral sclerosis MNDR Database
hsa-miR-381-3p autism spectrum disorder MNDR Database
hsa-miR-381-3p autistic disorder MNDR Database
hsa-miR-381-3p autosomal recessive limb-girdle muscular dystrophy type 2A MNDR Database
hsa-miR-381-3p autosomal recessive limb-girdle muscular dystrophy type 2B MNDR Database
hsa-miR-381-3p Barrett's adenocarcinoma MNDR Database
hsa-miR-381-3p bladder urothelial carcinoma MNDR Database
hsa-miR-381-3p bone disease MNDR Database
hsa-miR-381-3p brain disease MNDR Database
hsa-miR-381-3p breast cancer MNDR Database
hsa-miR-381-3p Breast Neoplasms MNDR Database
hsa-miR-381-3p cancer MNDR Database
hsa-miR-381-3p carcinoma MNDR Database
hsa-miR-381-3p Carcinoma, Ductal, Breast MNDR Database
hsa-miR-381-3p Carcinoma, Renal Cell MNDR Database
hsa-miR-381-3p cervical squamous cell carcinoma MNDR Database
hsa-miR-381-3p cholangiocarcinoma MNDR Database
hsa-miR-381-3p chronic fatigue syndrome MNDR Database
hsa-miR-381-3p colon cancer MNDR Database
hsa-miR-381-3p colorectal cancer MNDR Database
hsa-miR-381-3p dermatomyositis MNDR Database
hsa-miR-381-3p dilated cardiomyopathy MNDR Database
hsa-miR-381-3p distal muscular dystrophy MNDR Database
hsa-miR-381-3p Duchenne muscular dystrophy MNDR Database
hsa-miR-381-3p esophageal cancer MNDR Database
hsa-miR-381-3p esophageal carcinoma MNDR Database
hsa-miR-381-3p familiar ovarian carcinoma MNDR Database
hsa-miR-381-3p fragile X syndrome MNDR Database
hsa-miR-381-3p gastric adenocarcinoma MNDR Database
hsa-miR-381-3p Glioblastoma MNDR Database
hsa-miR-381-3p Growth Hormone-Secreting Pituitary Adenoma MNDR Database
hsa-miR-381-3p head and neck squamous cell carcinoma MNDR Database
hsa-miR-381-3p Heart Failure MNDR Database
hsa-miR-381-3p hepatocellular carcinoma MNDR Database
hsa-miR-381-3p Her2-receptor positive breast cancer MNDR Database
hsa-miR-381-3p Huntington's disease MNDR Database
hsa-miR-381-3p inclusion body myositis MNDR Database
hsa-miR-381-3p intellectual disability MNDR Database
hsa-miR-381-3p leukemia MNDR Database
hsa-miR-381-3p liposarcoma MNDR Database
hsa-miR-381-3p lung adenocarcinoma MNDR Database
hsa-miR-381-3p lung cancer MNDR Database
hsa-miR-381-3p lung small cell carcinoma MNDR Database
hsa-miR-381-3p lung squamous cell carcinoma MNDR Database
hsa-miR-381-3p lupus nephritis MNDR Database
hsa-miR-381-3p lymphoma MNDR Database
hsa-miR-381-3p major depressive disorder MNDR Database
hsa-miR-381-3p malignant glioma MNDR Database
hsa-miR-381-3p melanoma MNDR Database
hsa-miR-381-3p Muscular Disorders, Atrophic MNDR Database
hsa-miR-381-3p Myotonic Dystrophy MNDR Database
hsa-miR-381-3p nemaline myopathy MNDR Database
hsa-miR-381-3p nephroblastoma MNDR Database
hsa-miR-381-3p neurodegenerative disease MNDR Database
hsa-miR-381-3p oral squamous cell carcinoma MNDR Database
hsa-miR-381-3p osteosarcoma MNDR Database
hsa-miR-381-3p ovarian carcinoma MNDR Database
hsa-miR-381-3p ovarian clear cell carcinoma MNDR Database
hsa-miR-381-3p Ovarian Neoplasms MNDR Database
hsa-miR-381-3p pancreatic cancer MNDR Database
hsa-miR-381-3p pancreatic ductal adenocarcinoma MNDR Database
hsa-miR-381-3p papillary renal cell carcinoma MNDR Database
hsa-miR-381-3p pituitary adenoma MNDR Database
hsa-miR-381-3p progesterone-receptor negative breast cancer MNDR Database
hsa-miR-381-3p progesterone-receptor positive breast cancer MNDR Database
hsa-miR-381-3p prostate adenocarcinoma MNDR Database
hsa-miR-381-3p psoriasis MNDR Database
hsa-miR-381-3p pulmonary tuberculosis MNDR Database
hsa-miR-381-3p rectum adenocarcinoma MNDR Database
hsa-miR-381-3p renal cell carcinoma MNDR Database
hsa-miR-381-3p renal clear cell carcinoma MNDR Database
hsa-miR-381-3p stomach cancer MNDR Database
hsa-miR-381-3p Stroke, Lacunar MNDR Database
hsa-miR-381-3p systemic mastocytosis MNDR Database
hsa-miR-381-3p thyroid cancer MNDR Database
hsa-miR-381-3p thyroid carcinoma MNDR Database
hsa-miR-381-3p tonsil cancer MNDR Database
hsa-miR-381-3p urinary bladder cancer MNDR Database
hsa-miR-381-3p uterine cancer MNDR Database
hsa-miR-381-3p uterine corpus endometrial carcinoma MNDR Database
hsa-miR-381-3p vascular disease MNDR Database