Interaction ID
ncRI-40639291
Interaction Molecules
hsa-miR-544a -- ZBTB33
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
T-REx-293T
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSG00000177485
Description
Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-544a | adenocarcinoma | MNDR Database |
| hsa-miR-544a | amyotrophic lateral sclerosis | MNDR Database |
| hsa-miR-544a | autosomal recessive disease | MNDR Database |
| hsa-miR-544a | bone disease | MNDR Database |
| hsa-miR-544a | brain disease | MNDR Database |
| hsa-miR-544a | breast cancer | MNDR Database |
| hsa-miR-544a | cancer | MNDR Database |
| hsa-miR-544a | carcinoma | MNDR Database |
| hsa-miR-544a | cholangiocarcinoma | MNDR Database |
| hsa-miR-544a | colon cancer | MNDR Database |
| hsa-miR-544a | colorectal cancer | MNDR Database |
| hsa-miR-544a | diabetes mellitus | MNDR Database |
| hsa-miR-544a | eye disease | MNDR Database |
| hsa-miR-544a | familiar ovarian carcinoma | MNDR Database |
| hsa-miR-544a | Gaucher's disease | MNDR Database |
| hsa-miR-544a | Glioblastoma | MNDR Database |
| hsa-miR-544a | heart disease | MNDR Database |
| hsa-miR-544a | hepatocellular carcinoma | MNDR Database |
| hsa-miR-544a | hypersensitivity reaction type II disease | MNDR Database |
| hsa-miR-544a | intellectual disability | MNDR Database |
| hsa-miR-544a | kidney disease | MNDR Database |
| hsa-miR-544a | leukemia | MNDR Database |
| hsa-miR-544a | lung cancer | MNDR Database |
| hsa-miR-544a | lung disease | MNDR Database |
| hsa-miR-544a | lymphoma | MNDR Database |
| hsa-miR-544a | malignant glioma | MNDR Database |
| hsa-miR-544a | malignant pleural mesothelioma | MNDR Database |
| hsa-miR-544a | melanoma | MNDR Database |
| hsa-miR-544a | multiple myeloma | MNDR Database |
| hsa-miR-544a | nasopharynx carcinoma | MNDR Database |
| hsa-miR-544a | nephroblastoma | MNDR Database |
| hsa-miR-544a | neurodegenerative disease | MNDR Database |
| hsa-miR-544a | Neuroendocrine Tumors | MNDR Database |
| hsa-miR-544a | oligometastasis | MNDR Database |
| hsa-miR-544a | Ovarian Neoplasms | MNDR Database |
| hsa-miR-544a | pancreatic cancer | MNDR Database |
| hsa-miR-544a | progesterone-receptor positive breast cancer | MNDR Database |
| hsa-miR-544a | relapsing-remitting multiple sclerosis | MNDR Database |
| hsa-miR-544a | skin disease | MNDR Database |
| hsa-miR-544a | squamous cell carcinoma | MNDR Database |
| hsa-miR-544a | stomach cancer | MNDR Database |
| hsa-miR-544a | Uterine Cervical Neoplasms | MNDR Database |
| hsa-miR-544a | vascular disease | MNDR Database |