Interaction Profile
Interaction ID
ncRI-40639210
Interaction Molecules
hsa-let-7f-1-3p -- TCF7L2
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
T-REx-293T;normal;tumor
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Molecule Profile
Alias
-
Class
mRNA
Ensembl id
ENSG00000148737
Description
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
Reference Information
| Pubmed ID | 28735896 | Journal | Molecular cell |
|---|---|---|---|
| Title | Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer. | ||
| Author | Luna JM, Barajas JM, Teng KY, Sun HL, Moore MJ, Rice CM, Darnell RB, Ghoshal K | ||
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
Network View
Disease Annotation
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-let-7f-1-3p | acute myeloid leukemia | MNDR Database |
| hsa-let-7f-1-3p | acute T cell leukemia | MNDR Database |
| hsa-let-7f-1-3p | adenocarcinoma | MNDR Database |
| hsa-let-7f-1-3p | adrenocortical carcinoma | MNDR Database |
| hsa-let-7f-1-3p | Adrenocortical Carcinoma | MNDR Database |
| hsa-let-7f-1-3p | Alzheimer's disease | MNDR Database |
| hsa-let-7f-1-3p | amyotrophic lateral sclerosis | MNDR Database |
| hsa-let-7f-1-3p | asthma | MNDR Database |
| hsa-let-7f-1-3p | autosomal recessive disease | MNDR Database |
| hsa-let-7f-1-3p | Barrett's adenocarcinoma | MNDR Database |
| hsa-let-7f-1-3p | B-cell lymphoma | MNDR Database |
| hsa-let-7f-1-3p | biliary tract cancer | MNDR Database |
| hsa-let-7f-1-3p | brain disease | MNDR Database |
| hsa-let-7f-1-3p | breast cancer | MNDR Database |
| hsa-let-7f-1-3p | Breast Neoplasms | MNDR Database |
| hsa-let-7f-1-3p | bronchiolo-alveolar adenocarcinoma | MNDR Database |
| hsa-let-7f-1-3p | Burkitt lymphoma | MNDR Database |
| hsa-let-7f-1-3p | cancer | MNDR Database |
| hsa-let-7f-1-3p | carcinoma | MNDR Database |
| hsa-let-7f-1-3p | Carcinoma, Ductal, Breast | MNDR Database |
| hsa-let-7f-1-3p | Carcinoma, Non-Small-Cell Lung | MNDR Database |
| hsa-let-7f-1-3p | Carcinoma, Renal Cell | MNDR Database |
| hsa-let-7f-1-3p | cholangiocarcinoma | MNDR Database |
| hsa-let-7f-1-3p | chronic kidney disease | MNDR Database |
| hsa-let-7f-1-3p | chronic lymphocytic leukemia | MNDR Database |
| hsa-let-7f-1-3p | Cocaine-Related Disorders | MNDR Database |
| hsa-let-7f-1-3p | colon adenocarcinoma | MNDR Database |
| hsa-let-7f-1-3p | colon cancer | MNDR Database |
| hsa-let-7f-1-3p | colorectal cancer | MNDR Database |
| hsa-let-7f-1-3p | Crohn's disease | MNDR Database |
| hsa-let-7f-1-3p | cystic nephroma | MNDR Database |
| hsa-let-7f-1-3p | dermatomyositis | MNDR Database |
| hsa-let-7f-1-3p | diabetes mellitus | MNDR Database |
| hsa-let-7f-1-3p | DiGeorge syndrome | MNDR Database |
| hsa-let-7f-1-3p | Digestive System Neoplasms | MNDR Database |
| hsa-let-7f-1-3p | dilated cardiomyopathy | MNDR Database |
| hsa-let-7f-1-3p | embryonal cancer | MNDR Database |
| hsa-let-7f-1-3p | encephalomyelitis | MNDR Database |
| hsa-let-7f-1-3p | endometrial cancer | MNDR Database |
| hsa-let-7f-1-3p | endometriosis | MNDR Database |
| hsa-let-7f-1-3p | Ependymoma | MNDR Database |
| hsa-let-7f-1-3p | esophageal cancer | MNDR Database |
| hsa-let-7f-1-3p | Ewing sarcoma | MNDR Database |
| hsa-let-7f-1-3p | eye disease | MNDR Database |
| hsa-let-7f-1-3p | familiar ovarian carcinoma | MNDR Database |
| hsa-let-7f-1-3p | fragile X syndrome | MNDR Database |
| hsa-let-7f-1-3p | gallbladder adenocarcinoma | MNDR Database |
| hsa-let-7f-1-3p | gastric adenocarcinoma | MNDR Database |
| hsa-let-7f-1-3p | gastric lymphoma | MNDR Database |
| hsa-let-7f-1-3p | gastrointestinal system cancer | MNDR Database |
| hsa-let-7f-1-3p | Glioblastoma | MNDR Database |
| hsa-let-7f-1-3p | gout | MNDR Database |
| hsa-let-7f-1-3p | head and neck cancer | MNDR Database |
| hsa-let-7f-1-3p | head and neck squamous cell carcinoma | MNDR Database |
| hsa-let-7f-1-3p | heart disease | MNDR Database |
| hsa-let-7f-1-3p | Heart Failure | MNDR Database |
| hsa-let-7f-1-3p | hepatitis B | MNDR Database |
| hsa-let-7f-1-3p | hepatitis C | MNDR Database |
| hsa-let-7f-1-3p | hepatocellular carcinoma | MNDR Database |
| hsa-let-7f-1-3p | Her2-receptor positive breast cancer | MNDR Database |
| hsa-let-7f-1-3p | Hodgkin's lymphoma | MNDR Database |
| hsa-let-7f-1-3p | hypertension | MNDR Database |
| hsa-let-7f-1-3p | Hypertrophy | MNDR Database |
| hsa-let-7f-1-3p | inclusion body myositis | MNDR Database |
| hsa-let-7f-1-3p | Inflammation | MNDR Database |
| hsa-let-7f-1-3p | Influenza, Human | MNDR Database |
| hsa-let-7f-1-3p | intellectual disability | MNDR Database |
| hsa-let-7f-1-3p | interstitial lung disease | MNDR Database |
| hsa-let-7f-1-3p | intracranial aneurysm | MNDR Database |
| hsa-let-7f-1-3p | Intracranial Hemorrhage, Hypertensive | MNDR Database |
| hsa-let-7f-1-3p | Kaposi's sarcoma | MNDR Database |
| hsa-let-7f-1-3p | keratitis | MNDR Database |
| hsa-let-7f-1-3p | kidney cancer | MNDR Database |
| hsa-let-7f-1-3p | Lafora disease | MNDR Database |
| hsa-let-7f-1-3p | leiomyoma | MNDR Database |
| hsa-let-7f-1-3p | Lesch-Nyhan syndrome | MNDR Database |
| hsa-let-7f-1-3p | leukemia | MNDR Database |
| hsa-let-7f-1-3p | liposarcoma | MNDR Database |
| hsa-let-7f-1-3p | liver cancer | MNDR Database |
| hsa-let-7f-1-3p | Liver Neoplasms | MNDR Database |
| hsa-let-7f-1-3p | lung adenocarcinoma | MNDR Database |
| hsa-let-7f-1-3p | lung cancer | MNDR Database |
| hsa-let-7f-1-3p | lung disease | MNDR Database |
| hsa-let-7f-1-3p | lung squamous cell carcinoma | MNDR Database |
| hsa-let-7f-1-3p | Lymphoblastoid | MNDR Database |
| hsa-let-7f-1-3p | lymphoma | MNDR Database |
| hsa-let-7f-1-3p | Lymphoma, Non-Hodgkin | MNDR Database |
| hsa-let-7f-1-3p | Lymphoma, Primary Effusion | MNDR Database |
| hsa-let-7f-1-3p | Machado-Joseph disease | MNDR Database |
| hsa-let-7f-1-3p | macular degeneration | MNDR Database |
| hsa-let-7f-1-3p | malignant glioma | MNDR Database |
| hsa-let-7f-1-3p | malignant pleural mesothelioma | MNDR Database |
| hsa-let-7f-1-3p | medulloblastoma | MNDR Database |
| hsa-let-7f-1-3p | medulloepithelioma | MNDR Database |
| hsa-let-7f-1-3p | melanoma | MNDR Database |
| hsa-let-7f-1-3p | Mesothelioma | MNDR Database |
| hsa-let-7f-1-3p | metabolic syndrome X | MNDR Database |
| hsa-let-7f-1-3p | multiple myeloma | MNDR Database |
| hsa-let-7f-1-3p | Multiple Sclerosis, Chronic Progressive | MNDR Database |
| hsa-let-7f-1-3p | Muscular Disorders, Atrophic | MNDR Database |
| hsa-let-7f-1-3p | myasthenia gravis | MNDR Database |
| hsa-let-7f-1-3p | Myasthenia Gravis, Autoimmune, Experimental | MNDR Database |
| hsa-let-7f-1-3p | mycosis fungoides | MNDR Database |
| hsa-let-7f-1-3p | myelodysplastic/myeloproliferative neoplasm | MNDR Database |
| hsa-let-7f-1-3p | nasopharynx carcinoma | MNDR Database |
| hsa-let-7f-1-3p | nemaline myopathy | MNDR Database |
| hsa-let-7f-1-3p | Neoplasms | MNDR Database |
| hsa-let-7f-1-3p | nephroblastoma | MNDR Database |
| hsa-let-7f-1-3p | neuroblastoma | MNDR Database |
| hsa-let-7f-1-3p | neurodegenerative disease | MNDR Database |
| hsa-let-7f-1-3p | neuromyelitis optica | MNDR Database |
| hsa-let-7f-1-3p | Niemann-Pick disease | MNDR Database |
| hsa-let-7f-1-3p | oligodendroglioma | MNDR Database |
| hsa-let-7f-1-3p | oral squamous cell carcinoma | MNDR Database |
| hsa-let-7f-1-3p | osteosarcoma | MNDR Database |
| hsa-let-7f-1-3p | ovarian clear cell carcinoma | MNDR Database |
| hsa-let-7f-1-3p | Ovarian Neoplasms | MNDR Database |
| hsa-let-7f-1-3p | pancreatic cancer | MNDR Database |
| hsa-let-7f-1-3p | pancreatic ductal adenocarcinoma | MNDR Database |
| hsa-let-7f-1-3p | papillary renal cell carcinoma | MNDR Database |
| hsa-let-7f-1-3p | Parkinson's disease | MNDR Database |
| hsa-let-7f-1-3p | periodontitis | MNDR Database |
| hsa-let-7f-1-3p | pituitary adenoma | MNDR Database |
| hsa-let-7f-1-3p | pleuropulmonary blastoma | MNDR Database |
| hsa-let-7f-1-3p | Precursor Cell Lymphoblastic Leukemia-Lymphoma | MNDR Database |
| hsa-let-7f-1-3p | pre-eclampsia | MNDR Database |
| hsa-let-7f-1-3p | progesterone-receptor negative breast cancer | MNDR Database |
| hsa-let-7f-1-3p | progesterone-receptor positive breast cancer | MNDR Database |
| hsa-let-7f-1-3p | prostate adenocarcinoma | MNDR Database |
| hsa-let-7f-1-3p | Prostatic Neoplasms | MNDR Database |
| hsa-let-7f-1-3p | Pseudorabies | MNDR Database |
| hsa-let-7f-1-3p | rectum adenocarcinoma | MNDR Database |
| hsa-let-7f-1-3p | relapsing-remitting multiple sclerosis | MNDR Database |
| hsa-let-7f-1-3p | renal cell carcinoma | MNDR Database |
| hsa-let-7f-1-3p | renal clear cell carcinoma | MNDR Database |
| hsa-let-7f-1-3p | retinoblastoma | MNDR Database |
| hsa-let-7f-1-3p | Sarcopenia | MNDR Database |
| hsa-let-7f-1-3p | schizophrenia | MNDR Database |
| hsa-let-7f-1-3p | serous cystadenocarcinoma | MNDR Database |
| hsa-let-7f-1-3p | Sertoli-Leydig cell tumor | MNDR Database |
| hsa-let-7f-1-3p | skin disease | MNDR Database |
| hsa-let-7f-1-3p | squamous cell carcinoma | MNDR Database |
| hsa-let-7f-1-3p | stomach cancer | MNDR Database |
| hsa-let-7f-1-3p | Stroke | MNDR Database |
| hsa-let-7f-1-3p | Stroke, Lacunar | MNDR Database |
| hsa-let-7f-1-3p | synovial sarcoma | MNDR Database |
| hsa-let-7f-1-3p | systemic lupus erythematosus | MNDR Database |
| hsa-let-7f-1-3p | T-cell leukemia | MNDR Database |
| hsa-let-7f-1-3p | temporal lobe epilepsy | MNDR Database |
| hsa-let-7f-1-3p | thrombotic thrombocytopenic purpura | MNDR Database |
| hsa-let-7f-1-3p | thyroid cancer | MNDR Database |
| hsa-let-7f-1-3p | ulcerative colitis | MNDR Database |
| hsa-let-7f-1-3p | Urinary Bladder Neoplasms | MNDR Database |
| hsa-let-7f-1-3p | uterine cancer | MNDR Database |
| hsa-let-7f-1-3p | Uterine Cervical Neoplasms | MNDR Database |
| hsa-let-7f-1-3p | vascular disease | MNDR Database |
| hsa-let-7f-1-3p | X-linked disease | MNDR Database |
| hsa-let-7f-1-3p | diabetes mellitus, noninsulin-dependent | eDGAR Database |