Interaction ID
ncRI-40638802
Interaction Molecules
hsa-miR-559 -- MASTL
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
T-REx-293T;HEK293S
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSG00000120539
Description
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.
| Pubmed ID | 23824327 | Journal | Genes & development |
|---|---|---|---|
| Title | Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates. | ||
| Author | Karginov FV, Hannon GJ | ||
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-559 | adenoma | MNDR Database |
| hsa-miR-559 | brain disease | MNDR Database |
| hsa-miR-559 | breast cancer | MNDR Database |
| hsa-miR-559 | cancer | MNDR Database |
| hsa-miR-559 | colon cancer | MNDR Database |
| hsa-miR-559 | colorectal cancer | MNDR Database |
| hsa-miR-559 | familiar ovarian carcinoma | MNDR Database |
| hsa-miR-559 | hepatocellular carcinoma | MNDR Database |
| hsa-miR-559 | malignant glioma | MNDR Database |
| hsa-miR-559 | melanoma | MNDR Database |
| hsa-miR-559 | Multiple Sclerosis, Chronic Progressive | MNDR Database |
| hsa-miR-559 | nasopharynx carcinoma | MNDR Database |
| hsa-miR-559 | neurodegenerative disease | MNDR Database |
| hsa-miR-559 | pancreatic cancer | MNDR Database |
| hsa-miR-559 | relapsing-remitting multiple sclerosis | MNDR Database |
| hsa-miR-559 | stomach cancer | MNDR Database |
| hsa-miR-559 | vascular disease | MNDR Database |
| hsa-miR-559 | thrombocytopenia 2 | eDGAR Database |