Interaction ID
ncRI-40638671
Interaction Molecules
hsa-miR-603 -- YTHDC1
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
HEK293T;T-REx-293T;Cingulategyrus
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSG00000083896
Description
Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Involved in S- adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity).
| Pubmed ID | 24389009 | Journal | Neuron |
|---|---|---|---|
| Title | Transcriptome-wide discovery of microRNA binding sites in human brain. | ||
| Author | Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL | ||
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-603 | Alzheimer's disease | MNDR Database |
| hsa-miR-603 | arthritis | MNDR Database |
| hsa-miR-603 | Barrett's adenocarcinoma | MNDR Database |
| hsa-miR-603 | bone disease | MNDR Database |
| hsa-miR-603 | brain disease | MNDR Database |
| hsa-miR-603 | breast cancer | MNDR Database |
| hsa-miR-603 | Breast Neoplasms | MNDR Database |
| hsa-miR-603 | cancer | MNDR Database |
| hsa-miR-603 | carcinoma | MNDR Database |
| hsa-miR-603 | colon cancer | MNDR Database |
| hsa-miR-603 | colorectal cancer | MNDR Database |
| hsa-miR-603 | diabetes mellitus | MNDR Database |
| hsa-miR-603 | eye disease | MNDR Database |
| hsa-miR-603 | familiar ovarian carcinoma | MNDR Database |
| hsa-miR-603 | Glioblastoma | MNDR Database |
| hsa-miR-603 | Growth Hormone-Secreting Pituitary Adenoma | MNDR Database |
| hsa-miR-603 | heart disease | MNDR Database |
| hsa-miR-603 | intellectual disability | MNDR Database |
| hsa-miR-603 | kidney disease | MNDR Database |
| hsa-miR-603 | leukemia | MNDR Database |
| hsa-miR-603 | lung cancer | MNDR Database |
| hsa-miR-603 | lung disease | MNDR Database |
| hsa-miR-603 | malignant glioma | MNDR Database |
| hsa-miR-603 | melanoma | MNDR Database |
| hsa-miR-603 | multiple myeloma | MNDR Database |
| hsa-miR-603 | neurodegenerative disease | MNDR Database |
| hsa-miR-603 | osteosarcoma | MNDR Database |
| hsa-miR-603 | Ovarian Neoplasms | MNDR Database |
| hsa-miR-603 | pancreatic cancer | MNDR Database |
| hsa-miR-603 | pancreatic ductal adenocarcinoma | MNDR Database |
| hsa-miR-603 | pituitary adenoma | MNDR Database |
| hsa-miR-603 | progesterone-receptor negative breast cancer | MNDR Database |
| hsa-miR-603 | progesterone-receptor positive breast cancer | MNDR Database |
| hsa-miR-603 | stomach cancer | MNDR Database |
| hsa-miR-603 | vascular disease | MNDR Database |