Interaction: ncRI-40638503

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Interaction Profile

Interaction ID

ncRI-40638503

Interaction Molecules

hsa-miR-99b-3p -- CTNNB1

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

miRanda with Ago CLIP data

Tags

Organism

Homo sapiens

Tissue or Cell Type

HEK293T;T-REx-293T;tumor

Experiment

AGO CLIP

Description

Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset

Molecule Profile

hsa-miR-99b-3p

⇔

CTNNB1

Alias

-

Class

miRNA

miRBase id

MI0000746

Description

Homo sapiens miR-99b stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSG00000168036

Description

Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E- cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).

Reference Information
Pubmed ID 28735896 Journal Molecular cell
Title Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer.
Author Luna JM, Barajas JM, Teng KY, Sun HL, Moore MJ, Rice CM, Darnell RB, Ghoshal K
Pubmed ID 29273203 Journal Journal of molecular biology
Title Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets.
Author Li Y, Estep JA, Karginov FV
Network View
Disease Annotation
Molecule Disease Data Source
hsa-miR-99b-3p acromegaly MNDR Database
hsa-miR-99b-3p adenocarcinoma MNDR Database
hsa-miR-99b-3p Alzheimer's disease MNDR Database
hsa-miR-99b-3p amyotrophic lateral sclerosis MNDR Database
hsa-miR-99b-3p atherosclerosis MNDR Database
hsa-miR-99b-3p autosomal recessive limb-girdle muscular dystrophy type 2A MNDR Database
hsa-miR-99b-3p autosomal recessive limb-girdle muscular dystrophy type 2B MNDR Database
hsa-miR-99b-3p Barrett's adenocarcinoma MNDR Database
hsa-miR-99b-3p B-cell lymphoma MNDR Database
hsa-miR-99b-3p bone disease MNDR Database
hsa-miR-99b-3p brain disease MNDR Database
hsa-miR-99b-3p breast cancer MNDR Database
hsa-miR-99b-3p Breast Neoplasms MNDR Database
hsa-miR-99b-3p Burkitt lymphoma MNDR Database
hsa-miR-99b-3p cancer MNDR Database
hsa-miR-99b-3p Carcinoma, Ductal, Breast MNDR Database
hsa-miR-99b-3p Carcinoma, Renal Cell MNDR Database
hsa-miR-99b-3p cervical cancer MNDR Database
hsa-miR-99b-3p cholangiocarcinoma MNDR Database
hsa-miR-99b-3p chordoma MNDR Database
hsa-miR-99b-3p colon adenocarcinoma MNDR Database
hsa-miR-99b-3p colon cancer MNDR Database
hsa-miR-99b-3p colorectal cancer MNDR Database
hsa-miR-99b-3p dermatomyositis MNDR Database
hsa-miR-99b-3p diabetes mellitus MNDR Database
hsa-miR-99b-3p dilated cardiomyopathy MNDR Database
hsa-miR-99b-3p distal muscular dystrophy MNDR Database
hsa-miR-99b-3p Duke C MNDR Database
hsa-miR-99b-3p encephalomyelitis MNDR Database
hsa-miR-99b-3p endometriosis MNDR Database
hsa-miR-99b-3p esophageal cancer MNDR Database
hsa-miR-99b-3p facioscapulohumeral muscular dystrophy MNDR Database
hsa-miR-99b-3p familiar ovarian carcinoma MNDR Database
hsa-miR-99b-3p fibromyalgia MNDR Database
hsa-miR-99b-3p gastric lymphoma MNDR Database
hsa-miR-99b-3p Glioblastoma MNDR Database
hsa-miR-99b-3p Growth Hormone-Secreting Pituitary Adenoma MNDR Database
hsa-miR-99b-3p head and neck squamous cell carcinoma MNDR Database
hsa-miR-99b-3p hepatocellular carcinoma MNDR Database
hsa-miR-99b-3p Her2-receptor positive breast cancer MNDR Database
hsa-miR-99b-3p Hodgkin's lymphoma MNDR Database
hsa-miR-99b-3p Huntington's disease MNDR Database
hsa-miR-99b-3p Hypersomnolence, Idiopathic MNDR Database
hsa-miR-99b-3p intellectual disability MNDR Database
hsa-miR-99b-3p intracranial aneurysm MNDR Database
hsa-miR-99b-3p Intracranial Hemorrhage, Hypertensive MNDR Database
hsa-miR-99b-3p leukemia MNDR Database
hsa-miR-99b-3p liposarcoma MNDR Database
hsa-miR-99b-3p lung adenocarcinoma MNDR Database
hsa-miR-99b-3p lung cancer MNDR Database
hsa-miR-99b-3p lung small cell carcinoma MNDR Database
hsa-miR-99b-3p lung squamous cell carcinoma MNDR Database
hsa-miR-99b-3p Lymphoblastoid MNDR Database
hsa-miR-99b-3p lymphoma MNDR Database
hsa-miR-99b-3p Lymphoma, Non-Hodgkin MNDR Database
hsa-miR-99b-3p malignant glioma MNDR Database
hsa-miR-99b-3p malignant pleural mesothelioma MNDR Database
hsa-miR-99b-3p medulloblastoma MNDR Database
hsa-miR-99b-3p melanoma MNDR Database
hsa-miR-99b-3p multiple myeloma MNDR Database
hsa-miR-99b-3p Muscular Disorders, Atrophic MNDR Database
hsa-miR-99b-3p nasopharynx carcinoma MNDR Database
hsa-miR-99b-3p nemaline myopathy MNDR Database
hsa-miR-99b-3p nephroblastoma MNDR Database
hsa-miR-99b-3p neurodegenerative disease MNDR Database
hsa-miR-99b-3p oral squamous cell carcinoma MNDR Database
hsa-miR-99b-3p osteosarcoma MNDR Database
hsa-miR-99b-3p ovarian clear cell carcinoma MNDR Database
hsa-miR-99b-3p Ovarian Neoplasms MNDR Database
hsa-miR-99b-3p pancreatic adenocarcinoma MNDR Database
hsa-miR-99b-3p pancreatic cancer MNDR Database
hsa-miR-99b-3p pancreatic ductal adenocarcinoma MNDR Database
hsa-miR-99b-3p papillary renal cell carcinoma MNDR Database
hsa-miR-99b-3p pituitary adenoma MNDR Database
hsa-miR-99b-3p Polymyositis MNDR Database
hsa-miR-99b-3p Precursor Cell Lymphoblastic Leukemia-Lymphoma MNDR Database
hsa-miR-99b-3p progesterone-receptor negative breast cancer MNDR Database
hsa-miR-99b-3p progesterone-receptor positive breast cancer MNDR Database
hsa-miR-99b-3p prostate adenocarcinoma MNDR Database
hsa-miR-99b-3p Prostatic Neoplasms MNDR Database
hsa-miR-99b-3p psoriasis MNDR Database
hsa-miR-99b-3p rectum adenocarcinoma MNDR Database
hsa-miR-99b-3p relapsing-remitting multiple sclerosis MNDR Database
hsa-miR-99b-3p renal cell carcinoma MNDR Database
hsa-miR-99b-3p renal clear cell carcinoma MNDR Database
hsa-miR-99b-3p salivary gland cancer MNDR Database
hsa-miR-99b-3p Seizures MNDR Database
hsa-miR-99b-3p Sleep Deprivation MNDR Database
hsa-miR-99b-3p small intestine cancer MNDR Database
hsa-miR-99b-3p stomach cancer MNDR Database
hsa-miR-99b-3p Subarachnoid Hemorrhage, Traumatic MNDR Database
hsa-miR-99b-3p synovial sarcoma MNDR Database
hsa-miR-99b-3p temporal lobe epilepsy MNDR Database
hsa-miR-99b-3p thyroid cancer MNDR Database
hsa-miR-99b-3p thyroid carcinoma MNDR Database
hsa-miR-99b-3p urinary bladder cancer MNDR Database
hsa-miR-99b-3p Urinary Bladder Neoplasms MNDR Database
hsa-miR-99b-3p uterine corpus endometrial carcinoma MNDR Database
hsa-miR-99b-3p Uterine Cervical Neoplasms MNDR Database
hsa-miR-99b-3p vascular disease MNDR Database
hsa-miR-99b-3p colorectal cancer eDGAR Database
hsa-miR-99b-3p hepatocellular carcinoma eDGAR Database
hsa-miR-99b-3p medulloblastoma eDGAR Database
hsa-miR-99b-3p mental retardation, autosomal dominant eDGAR Database
hsa-miR-99b-3p ovarian cancer eDGAR Database
hsa-miR-99b-3p pilomatrixoma eDGAR Database