Interaction Profile
Interaction ID
ncRI-40487007
Interaction Molecules
RP1-283E3.8 -- SFRS7
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Homo sapiens
Tissue or Cell Type
K562;HepG2
Experiment
eCLIP
Description
eCLIP experiment on HepG2 against SRSF7
Molecule Profile
Alias
SRSF7
Class
protein
UniProt id
Description
Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.
Reference Information
| Pubmed ID | 22955616 | Journal | Nature |
|---|---|---|---|
| Title | An integrated encyclopedia of DNA elements in the human genome. | ||
| Author | |||
Binding Sites
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 8993799 | chr1:1635032-1635056 | 0.990333 |
| 8993902 | chr1:1636348-1636404 | 0.964411 |
| 8993970 | chr1:1640205-1640232 | 0.188667 |
| 8994084 | chr1:1647831-1647837 | 0.992333 |
| 8994085 | chr1:1647876-1647879 | 0.928000 |
| 8994086 | chr1:1647886-1647919 | 0.794879 |
| 8994134 | chr1:1650839-1650866 | 0.990667 |
| 8994183 | chr1:1655692-1655756 | 0.823469 |
| 8994475 | chr1:1666234-1666255 | 0.967857 |
| 8994477 | chr1:1666241-1666267 | 0.869077 |
Network View
Disease Annotation
| Molecule | Disease | Data Source |
|---|---|---|
| RP1-283E3.8 | Carcinoma, Non-Small-Cell Lung | MNDR Database |
| RP1-283E3.8 | lymphoma | MNDR Database |
| RP1-283E3.8 | malignant glioma | MNDR Database |
| RP1-283E3.8 | stomach cancer | MNDR Database |
| RP1-283E3.8 | thyroid cancer | MNDR Database |
| RP1-283E3.8 | Urinary Bladder Neoplasms | MNDR Database |
| RP1-283E3.8 | Uterine Cervical Neoplasms | MNDR Database |