Interaction Profile
Interaction ID
ncRI-40193799
Interaction Molecules
NSUN4 -- FUS
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Homo sapiens
Tissue or Cell Type
human brain
Experiment
CLIP-Seq
Description
CLIP of Fus/Tls in adult human brain.
Molecule Profile
Alias
FUS_mutant;FUS/TLS
Class
protein
UniProt id
Description
Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.
Reference Information
| Pubmed ID | 23023293 | Journal | Nature neuroscience |
|---|---|---|---|
| Title | Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. | ||
| Author | Lagier-Tourenne C, Polymenidou M, Hutt KR, Vu AQ, Baughn M, Huelga SC, Clutario KM, Ling SC, Liang TY, Mazur C, Wancewicz E, Kim AS, Watt A, Freier S, Hicks GG, Donohue JP, Shiue L, Bennett CF, Ravits J, Cleveland DW, Yeo GW | ||
Binding Sites
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 3801080 | chr1:46806511-46806546 | 0.226885714286 |
| 3801081 | chr1:46807027-46807062 | 0.592085714286 |
| 3801086 | chr1:46810490-46810525 | 0.886542857143 |
| 3801087 | chr1:46810573-46810608 | 0.998828571429 |
| 3801088 | chr1:46810612-46810668 | 0.475767857143 |
| 3801090 | chr1:46810794-46810829 | 0.820685714286 |
Network View
Disease Annotation
| Molecule | Disease | Data Source |
|---|---|---|
| NSUN4 | amyotrophic lateral sclerosis | eDGAR Database |
| NSUN4 | tremor, hereditary essential | eDGAR Database |