Interaction ID
ncRI-40118431
Interaction Molecules
TM2D1 -- hnRNPC
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Homo sapiens
Tissue or Cell Type
HeLa
Experiment
iCLIP
Description
Quantitative iCLIP reveals genome-wide competition of hnRNP C and U2AF65;CLIPseq data were analysed by CLIPdb
Alias
HNRPC
Class
protein
UniProt id
Description
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). Single HNRNPC tetramers bind 230-2
| Pubmed ID | 23374342 | Journal | Cell |
|---|---|---|---|
| Title | Direct competition between hnRNP C and U2AF65 protects the transcriptome from the exonization of Alu elements. | ||
| Author | Zarnack K, König J, Tajnik M, Martincorena I, Eustermann S, Stévant I, Reyes A, Anders S, Luscombe NM, Ule J | ||
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 462696 | chr1:62146861-62146881 | 0.5728 |
| 462706 | chr1:62146961-62146981 | 0.05115 |
| 462732 | chr1:62147981-62148001 | 0.03575 |
| 462734 | chr1:62148141-62148161 | 0.2262 |
| 462751 | chr1:62149561-62149581 | 0.0024 |
| 462758 | chr1:62150341-62150361 | 0.00085 |
| 462763 | chr1:62151021-62151041 | 0.67665 |
| 462764 | chr1:62151101-62151121 | 0.008 |
| 462774 | chr1:62151361-62151381 | 0.0776 |
| 462785 | chr1:62151681-62151701 | 0.09805 |
| 462795 | chr1:62151941-62151961 | 0.01205 |
| 462801 | chr1:62152121-62152141 | 0.00465 |
| 462806 | chr1:62152301-62152321 | 0.06595 |
| 462822 | chr1:62152841-62152861 | 0.27355 |
| 462841 | chr1:62153181-62153201 | 0.20555 |
| 462846 | chr1:62153341-62153361 | 0.01225 |
| 462848 | chr1:62153501-62153521 | 0.0023 |
| 462851 | chr1:62153881-62153901 | 0.01735 |
| 462860 | chr1:62154201-62154221 | 0.00725 |
| 462861 | chr1:62154361-62154381 | 0.10935 |
| 462863 | chr1:62154681-62154701 | 0.00345 |
| 462864 | chr1:62154901-62154941 | 0.0397 |
| 462873 | chr1:62155761-62155781 | 0.0077 |
| 462875 | chr1:62156081-62156101 | 0.0559 |
| 462880 | chr1:62156361-62156381 | 0.01035 |
| 462899 | chr1:62156821-62156841 | 0.0052 |
| 462901 | chr1:62156961-62156981 | 0.0668 |
| 462902 | chr1:62157161-62157181 | 0.0556 |
| 462904 | chr1:62157541-62157561 | 0.0026 |
| 462939 | chr1:62158701-62158721 | 0.0004 |
| 462972 | chr1:62160641-62160661 | 0.1034 |
| 462982 | chr1:62160801-62160821 | 0.00105 |
| 463000 | chr1:62161181-62161201 | 0.3905 |
| 463035 | chr1:62162181-62162201 | 0.00605 |
| 463226 | chr1:62164181-62164201 | 0.00355 |
| 463228 | chr1:62164301-62164321 | 0.1269 |
| 463241 | chr1:62164821-62164861 | 0.016 |
| 463643 | chr1:62174501-62174521 | 0.00035 |
| 463675 | chr1:62178801-62178821 | 0.01915 |
| 463676 | chr1:62179121-62179141 | 0.00205 |
| 463679 | chr1:62180581-62180601 | 0.1912 |
| 463701 | chr1:62180921-62180941 | 0.08775 |
| 463702 | chr1:62181281-62181301 | 0.1257 |
| 463729 | chr1:62183241-62183261 | 0.0336 |
| 463731 | chr1:62183641-62183661 | 0.0286 |
| 463732 | chr1:62183641-62183681 | 0.0311 |
| 463733 | chr1:62184121-62184141 | 0.00265 |
| 463734 | chr1:62184221-62184241 | 0.1035 |
| 463736 | chr1:62184501-62184541 | 0.4185 |
| 463749 | chr1:62185501-62185521 | 0.7499 |
| 463761 | chr1:62187001-62187021 | 0.4855 |
| 463762 | chr1:62187001-62187041 | 0.297075 |
| 463769 | chr1:62187261-62187281 | 0.0304 |
| 463773 | chr1:62187441-62187461 | 0.0042 |
| 463776 | chr1:62187581-62187601 | 0.0027 |
| 463777 | chr1:62187741-62187761 | 0.06895 |
| 463784 | chr1:62188541-62188561 | 0.01685 |
| 463821 | chr1:62189901-62189921 | 0.664 |
| 463822 | chr1:62190061-62190081 | 0.00865 |
| 463823 | chr1:62190161-62190181 | 0.00285 |
| 463825 | chr1:62190341-62190361 | 0.00195 |