Interaction ID
ncRI-40059756
Interaction Molecules
RP11-206L10.11 -- ELAVL1
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Homo sapiens
Tissue or Cell Type
HEK293
Experiment
PAR-CLIP
Description
PAR-CLIP identifies transcriptome-wide binding sites of ELAVL1 under Mnase treated condition.
Alias
ELAVL1
Class
protein
UniProt id
Description
RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element o
| Pubmed ID | 21572407 | Journal | Nature methods |
|---|---|---|---|
| Title | A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins. | ||
| Author | Kishore S, Jaskiewicz L, Burger L, Hausser J, Khorshid M, Zavolan M | ||
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 1462132 | chr1:789368-789408 | 0.003425 |