Interaction ID

ncRI-40050708

Interaction Molecules

SNHG7 -- SFRS1

Interaction Level

RNA-Protein

Interaction Class

binding

Data Source

High-throughput data

Tags

Organism

Homo sapiens

Tissue or Cell Type

K562;HEK293T;HepG2;T-REx-293T

Experiment

eCLIP;CLIP-Seq;CLIP

Description

Cross-linking immunoprecipitation and high-throughput sequencing (CLIP-seq) identified binding sites for SFRS1 in the transcriptome of cultured human embryonic kidney cells. SFRS1 was found to engage many different classes of functionally distinct transcripts including mRNA, miRNA, snoRNAs, ncRNAs, and conserved intergenic transcripts of unknown function.

Alias

RPI001_1000983;RPI001_156466

Class

lncRNA

NONCODE id

NONHSAG053806

Description

Antisense

Alias

SRSF1

Class

protein

UniProt id

J3KTL2

Description

Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CG