Interaction Profile
Interaction ID
ncRI-40046798
Interaction Molecules
RP11-540K16.1 -- WDR33
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Homo sapiens
Tissue or Cell Type
HEK293
Experiment
PAR-CLIP
Description
PAR-CLIP showed that WDR33 binds in and very close to the AAUAAA signal
Molecule Profile
Alias
WDR33
Class
protein
UniProt id
Description
Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.
Reference Information
| Pubmed ID | 25301781 | Journal | Genes & development |
|---|---|---|---|
| Title | Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33. | ||
| Author | Schönemann L, Kühn U, Martin G, Schäfer P, Gruber AR, Keller W, Zavolan M, Wahle E | ||
Binding Sites
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 153536 | chr1:181145529-181145549 | 0.0461 |
| 153537 | chr1:181150362-181150407 | 0.252 |
Network View
Disease Annotation
| Molecule | Disease | Data Source |
|---|---|---|
| RP11-540K16.1 | Carcinoma, Non-Small-Cell Lung | MNDR Database |
| RP11-540K16.1 | lymphoma | MNDR Database |
| RP11-540K16.1 | malignant glioma | MNDR Database |
| RP11-540K16.1 | stomach cancer | MNDR Database |
| RP11-540K16.1 | thyroid cancer | MNDR Database |
| RP11-540K16.1 | Urinary Bladder Neoplasms | MNDR Database |
| RP11-540K16.1 | Uterine Cervical Neoplasms | MNDR Database |