Interaction Profile
Interaction ID
ncRI-40040368
Interaction Molecules
PVT1 -- RBPMS
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Homo sapiens
Tissue or Cell Type
HEK293
Experiment
PAR-CLIP
Description
RBPMS PAR-CLIP-identified transcriptome-wide RNA-binding sites
Molecule Profile
Alias
RBPMS
Class
protein
UniProt id
Description
Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.
Reference Information
| Pubmed ID | 24860013 | Journal | RNA (New York, N.Y.) |
|---|---|---|---|
| Title | Identification of the RNA recognition element of the RBPMS family of RNA-binding proteins and their transcriptome-wide mRNA targets. | ||
| Author | Farazi TA, Leonhardt CS, Mukherjee N, Mihailovic A, Li S, Max KE, Meyer C, Yamaji M, Cekan P, Jacobs NC, Gerstberger S, Bognanni C, Larsson E, Ohler U, Tuschl T | ||
Binding Sites
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 1236251 | chr8:128819899-128819924 | 0.00176 |
| 1236959 | chr8:128928203-128928230 | 0.000296296296296 |
| 1237267 | chr8:128961871-128961893 | 0.208454545455 |
| 1237505 | chr8:128987536-128987561 | 0.00512 |
| 1237897 | chr8:129020095-129020123 | 0.000142857142857 |
| 1238023 | chr8:129028185-129028205 | 0.00115 |
| 1238401 | chr8:129060337-129060365 | 0.00628571428571 |
| 1238453 | chr8:129068228-129068248 | 0.0003 |
| 1238562 | chr8:129082621-129082645 | 0.202416666667 |
Network View
Disease Annotation
| Molecule | Disease | Data Source |
|---|---|---|
| PVT1 | acquired immunodeficiency syndrome | MNDR Database |
| PVT1 | acute promyelocytic leukemia | LncRNADisease Database |
| PVT1 | acute promyelocytic leukemia | MNDR Database |
| PVT1 | Alzheimer's disease | MNDR Database |
| PVT1 | asthma | LncRNADisease Database |
| PVT1 | asthma | MNDR Database |
| PVT1 | astrocytoma | MNDR Database |
| PVT1 | B-cell lymphoma | LncRNADisease Database |
| PVT1 | B-cell lymphoma | MNDR Database |
| PVT1 | bladder cancer | LncRNADisease Database |
| PVT1 | breast cancer | LncRNADisease Database |
| PVT1 | breast cancer | MNDR Database |
| PVT1 | Burkitt lymphoma | LncRNADisease Database |
| PVT1 | Burkitt lymphoma | MNDR Database |
| PVT1 | cancer | LncRNADisease Database |
| PVT1 | cancer | MNDR Database |
| PVT1 | Carcinoma, Non-Small-Cell Lung | MNDR Database |
| PVT1 | cardiac hypertrophy | LncRNADisease Database |
| PVT1 | Cardiomegaly | MNDR Database |
| PVT1 | cervical cancer | LncRNADisease Database |
| PVT1 | cleft lip | LncRNADisease Database |
| PVT1 | cleft lip | MNDR Database |
| PVT1 | colorectal cancer | LncRNADisease Database |
| PVT1 | colorectal cancer | MNDR Database |
| PVT1 | diabetes mellitus | MNDR Database |
| PVT1 | diabetic kidney disease | LncRNADisease Database |
| PVT1 | diabetic nephropathy | LncRNADisease Database |
| PVT1 | Diabetic Nephropathies | MNDR Database |
| PVT1 | esophageal cancer | LncRNADisease Database |
| PVT1 | esophageal cancer | MNDR Database |
| PVT1 | gastric cancer | LncRNADisease Database |
| PVT1 | hematologic cancer | MNDR Database |
| PVT1 | hematological malignancies | LncRNADisease Database |
| PVT1 | hepatocellular carcinoma | LncRNADisease Database |
| PVT1 | hepatocellular carcinoma | MNDR Database |
| PVT1 | Hodgkin's lymphoma | LncRNADisease Database |
| PVT1 | Hodgkin's lymphoma | MNDR Database |
| PVT1 | Huntington's disease | MNDR Database |
| PVT1 | kidney cancer | LncRNADisease Database |
| PVT1 | kidney cancer | MNDR Database |
| PVT1 | lung cancer | MNDR Database |
| PVT1 | lung squamous cell carcinoma | LncRNADisease Database |
| PVT1 | lung squamous cell carcinoma | MNDR Database |
| PVT1 | lymphoma | LncRNADisease Database |
| PVT1 | lymphoma | MNDR Database |
| PVT1 | malignant glioma | MNDR Database |
| PVT1 | malignant pleural mesothelioma | MNDR Database |
| PVT1 | melanoma | MNDR Database |
| PVT1 | multiple myeloma | LncRNADisease Database |
| PVT1 | multiple myeloma | MNDR Database |
| PVT1 | neuroblastoma | MNDR Database |
| PVT1 | non-small cell lung cancer | LncRNADisease Database |
| PVT1 | osteosarcoma | MNDR Database |
| PVT1 | ovarian cancer | LncRNADisease Database |
| PVT1 | Ovarian Neoplasms | MNDR Database |
| PVT1 | pancreatic cancer | LncRNADisease Database |
| PVT1 | pancreatic cancer | MNDR Database |
| PVT1 | pancreatic ductal adenocarcinoma | MNDR Database |
| PVT1 | plasmacytoma | LncRNADisease Database |
| PVT1 | plasmacytoma | MNDR Database |
| PVT1 | pleural mesothelioma | LncRNADisease Database |
| PVT1 | Prader-Willi syndrome | MNDR Database |
| PVT1 | prostate cancer | LncRNADisease Database |
| PVT1 | Prostatic Neoplasms | MNDR Database |
| PVT1 | renal carcinoma | LncRNADisease Database |
| PVT1 | renal carcinoma | MNDR Database |
| PVT1 | renal cell carcinoma | LncRNADisease Database |
| PVT1 | renal cell carcinoma | MNDR Database |
| PVT1 | schizophrenia | MNDR Database |
| PVT1 | stomach cancer | MNDR Database |
| PVT1 | thyroid cancer | LncRNADisease Database |
| PVT1 | thyroid cancer | MNDR Database |
| PVT1 | type 1 diabetes mellitus | MNDR Database |
| PVT1 | type 2 diabetes mellitus | LncRNADisease Database |
| PVT1 | type 2 diabetes mellitus | MNDR Database |
| PVT1 | urinary bladder cancer | MNDR Database |
| PVT1 | Urinary Bladder Neoplasms | MNDR Database |
| PVT1 | Uterine Cervical Neoplasms | MNDR Database |