Interaction Profile
Interaction ID
ncRI-40006852
Interaction Molecules
Xist -- Fus
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
Literature mining;High-throughput data
Tags
Organism
Mus musculus
Tissue or Cell Type
ESC;trophoblast stem cells;EpiSC;mouse brain;cerebrums
Experiment
HITS-CLIP;CLIP-Seq;CHIRP-MS
Description
ChIRP-MS identi?es endogenous protein partners associated with Xist
Molecule Profile
Alias
Fus/TLS
Class
protein
UniProt id
Description
Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.
Reference Information
| Pubmed ID | 22829983 | Journal | Scientific reports |
|---|---|---|---|
| Title | Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions. | ||
| Author | Ishigaki S, Masuda A, Fujioka Y, Iguchi Y, Katsuno M, Shibata A, Urano F, Sobue G, Ohno K | ||
| Pubmed ID | 23023293 | Journal | Nature neuroscience |
|---|---|---|---|
| Title | Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. | ||
| Author | Lagier-Tourenne C, Polymenidou M, Hutt KR, Vu AQ, Baughn M, Huelga SC, Clutario KM, Ling SC, Liang TY, Mazur C, Wancewicz E, Kim AS, Watt A, Freier S, Hicks GG, Donohue JP, Shiue L, Bennett CF, Ravits J, Cleveland DW, Yeo GW | ||
| Pubmed ID | 25843628 | Journal | Cell |
|---|---|---|---|
| Title | Systematic discovery of Xist RNA binding proteins. | ||
| Author | Chu C, Zhang QC, da Rocha ST, Flynn RA, Bharadwaj M, Calabrese JM, Magnuson T, Heard E, Chang HY | ||
Binding Sites
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 8231313 | chrX:100655787-100655840 | 0.0340754716981 |
| 8231322 | chrX:100655946-100655983 | 0.0529189189189 |
| 8231328 | chrX:100655986-100656013 | 0.481037037037 |
| 8231334 | chrX:100656045-100656072 | 0.999666666667 |
| 8231337 | chrX:100656076-100656086 | 0.8489 |
| 8231340 | chrX:100656088-100656182 | 0.0627446808511 |
| 8231343 | chrX:100656337-100656452 | 0.00720869565217 |
| 8231346 | chrX:100656462-100656499 | 0.00318918918919 |
| 8231352 | chrX:100656605-100656639 | 0.654264705882 |
| 8231355 | chrX:100656648-100656662 | 0.0357142857143 |
| 8231358 | chrX:100656697-100656703 | 0.441833333333 |
| 8231361 | chrX:100656711-100656715 | 0.02475 |
| 8231364 | chrX:100656734-100656825 | 0.0370549450549 |
| 8231367 | chrX:100656837-100656872 | 0.0132857142857 |
| 8231370 | chrX:100656900-100656953 | 0.0112264150943 |
| 8231373 | chrX:100656958-100656990 | 0.078 |
| 8231376 | chrX:100656992-100657059 | 0.00688059701493 |
| 8231382 | chrX:100657146-100657184 | 0.0132368421053 |
| 8231385 | chrX:100657225-100657390 | 0.0509636363636 |
| 8231391 | chrX:100657418-100657484 | 0.0160909090909 |
| 8231397 | chrX:100657490-100657499 | 0.126 |
| 8231400 | chrX:100657523-100657548 | 0.01204 |
| 8231403 | chrX:100657672-100657742 | 0.0160571428571 |
| 8231409 | chrX:100657755-100657790 | 0.0307142857143 |
| 8231415 | chrX:100657833-100657888 | 0.0129272727273 |
| 8231418 | chrX:100657955-100657987 | 0.33340625 |
| 8231421 | chrX:100657989-100658024 | 0.00345714285714 |
| 8231424 | chrX:100658082-100658143 | 0.0793770491803 |
| 8231427 | chrX:100658264-100658301 | 0.0375675675676 |
| 8231436 | chrX:100658343-100658387 | 0.298159090909 |
| 8231442 | chrX:100658404-100658439 | 0.00334285714286 |
| 8231445 | chrX:100658443-100658486 | 0.12 |
| 8231448 | chrX:100658522-100658557 | 0.147542857143 |
| 8231451 | chrX:100658577-100658612 | 0.0322571428571 |
| 8231454 | chrX:100658615-100658657 | 0.0249761904762 |
| 8231460 | chrX:100658668-100658730 | 0.0105967741935 |
| 8231469 | chrX:100658761-100658810 | 0.0211224489796 |
| 8231472 | chrX:100658813-100658842 | 0.105413793103 |
| 8231478 | chrX:100658846-100658876 | 0.176433333333 |
| 8231481 | chrX:100658883-100658903 | 0.00375 |
| 8231484 | chrX:100658911-100658968 | 0.0185208333333 |
| 8231487 | chrX:100658973-100659045 | 0.125514285714 |
| 8231490 | chrX:100659049-100659110 | 0.170590163934 |
| 8231496 | chrX:100659134-100659198 | 0.06834375 |
| 8231499 | chrX:100659204-100659252 | 0.0149375 |
| 8231502 | chrX:100659264-100659299 | 0.00194285714286 |
| 8231505 | chrX:100659311-100659330 | 0.000789473684211 |
| 8231508 | chrX:100659334-100659404 | 0.0351428571429 |
| 8231511 | chrX:100659429-100659496 | 0.132373134328 |
| 8231517 | chrX:100659529-100659603 | 0.0531216216216 |
| 8231520 | chrX:100659650-100659727 | 0.0236233766234 |
| 8231526 | chrX:100659734-100659771 | 0.0442702702703 |
| 8231529 | chrX:100659813-100659861 | 0.00539583333333 |
| 8231532 | chrX:100659864-100660092 | 0.0596842105263 |
| 8231535 | chrX:100660096-100660166 | 0.000657142857143 |
| 8231541 | chrX:100660172-100660211 | 0.0107435897436 |
| 8231544 | chrX:100660261-100660352 | 0.0188241758242 |
| 8231550 | chrX:100660353-100660418 | 0.0631538461538 |
| 8231559 | chrX:100660438-100660592 | 0.0410844155844 |
| 8231565 | chrX:100660630-100660689 | 0.00403389830508 |
| 8231568 | chrX:100660694-100660794 | 0.01023 |
| 8231574 | chrX:100660797-100660835 | 0.0239736842105 |
| 8231577 | chrX:100660836-100660919 | 0.0165903614458 |
| 8231580 | chrX:100660926-100660958 | 0.28125 |
| 8231583 | chrX:100661065-100661091 | 0.359 |
| 8231589 | chrX:100661168-100661193 | 0.2246 |
| 8231592 | chrX:100661202-100661260 | 0.286862068966 |
| 8231598 | chrX:100661284-100661320 | 0.00730555555556 |
| 8231601 | chrX:100661354-100661648 | 0.0193639455782 |
| 8231613 | chrX:100661803-100661825 | 0.0174090909091 |
| 8231616 | chrX:100661826-100661832 | 0.00216666666667 |
| 8231622 | chrX:100661937-100662057 | 0.0843083333333 |
| 8231628 | chrX:100662077-100662082 | 0.0002 |
| 8231634 | chrX:100662108-100662112 | 0.002 |
| 8231646 | chrX:100662195-100662244 | 0.108387755102 |
| 8231649 | chrX:100662249-100662267 | 0.205333333333 |
| 8231652 | chrX:100662271-100662284 | 0.0574615384615 |
| 8231658 | chrX:100662300-100662306 | 0.00583333333333 |
| 8231661 | chrX:100662371-100662384 | 0.0214615384615 |
| 8231670 | chrX:100662493-100662531 | 0.0180789473684 |
| 8231676 | chrX:100662604-100662660 | 0.0522142857143 |
| 8231682 | chrX:100662671-100662689 | 0.000611111111111 |
| 8231688 | chrX:100662801-100662821 | 0.0179 |
| 8231691 | chrX:100662872-100662904 | 0.00625 |
| 8231694 | chrX:100662960-100662995 | 0.0103714285714 |
| 8231697 | chrX:100663040-100663072 | 0.04640625 |
| 8231700 | chrX:100663209-100663211 | 0.001 |
| 8231703 | chrX:100663224-100663237 | 0.00353846153846 |
| 8231709 | chrX:100663297-100663355 | 0.00515517241379 |
| 8231721 | chrX:100664235-100664270 | 0.00734285714286 |
| 8231726 | chrX:100664731-100664756 | 0.0094 |
| 8231728 | chrX:100664957-100664964 | 0.00214285714286 |
| 8231734 | chrX:100665091-100665127 | 0.901611111111 |
| 8231743 | chrX:100665974-100666004 | 0.0764 |
| 8231760 | chrX:100669059-100669082 | 0.973869565217 |
| 8231762 | chrX:100669114-100669149 | 0.329342857143 |
| 8231766 | chrX:100669211-100669251 | 0.234034482759 |
| 8231770 | chrX:100669294-100669338 | 0.558340909091 |
| 8231772 | chrX:100669343-100669375 | 0.216375 |
| 8231774 | chrX:100669384-100669554 | 0.102947058824 |
| 8231776 | chrX:100669557-100669578 | 0.112952380952 |
| 8231780 | chrX:100669617-100669645 | 0.0415 |
| 8231782 | chrX:100669668-100669716 | 0.0443958333333 |
| 8231786 | chrX:100669734-100669908 | 0.0198045977011 |
| 8231792 | chrX:100669909-100669941 | 0.5735 |
| 8231794 | chrX:100669959-100670070 | 0.191576576577 |
| 8231800 | chrX:100670195-100670217 | 0.00554545454545 |
| 8231802 | chrX:100670221-100670255 | 0.0186176470588 |
| 8231806 | chrX:100670320-100670345 | 0.21128 |
| 8231808 | chrX:100670366-100670416 | 0.1063 |
| 8231814 | chrX:100670433-100670509 | 0.128276315789 |
| 8231818 | chrX:100670517-100670542 | 0.01092 |
| 8231820 | chrX:100670564-100670587 | 0.114565217391 |
| 8231822 | chrX:100670592-100670676 | 0.0356428571429 |
| 8231824 | chrX:100670684-100670743 | 0.00277966101695 |
| 8231828 | chrX:100670772-100670824 | 0.00746153846154 |
| 8231830 | chrX:100670826-100670906 | 0.000725 |
| 8231834 | chrX:100670915-100670945 | 0.00446666666667 |
| 8231836 | chrX:100670956-100670977 | 0.00585714285714 |
| 8231840 | chrX:100671010-100671080 | 0.00945714285714 |
| 8231842 | chrX:100671094-100671129 | 0.001 |
| 8231846 | chrX:100671163-100671198 | 0.00197142857143 |
| 8231850 | chrX:100671270-100671291 | 0.00433333333333 |
| 8231852 | chrX:100671362-100671412 | 0.02714 |
| 8231856 | chrX:100671475-100671494 | 0.00373684210526 |
| 8231858 | chrX:100671496-100671497 | 0.0 |
| 8231860 | chrX:100671550-100671586 | 0.0551111111111 |
| 8231862 | chrX:100671651-100671740 | 0.00396629213483 |
| 8231864 | chrX:100671749-100671807 | 0.00491379310345 |
| 8231866 | chrX:100671826-100671888 | 0.00838709677419 |
| 8231868 | chrX:100672017-100672056 | 0.006 |
| 8231872 | chrX:100672264-100672277 | 0.00292307692308 |
| 8231874 | chrX:100672428-100672470 | 0.141595238095 |
| 8231876 | chrX:100672484-100672506 | 0.00409090909091 |
| 8231878 | chrX:100672542-100672569 | 0.531777777778 |
| 8231880 | chrX:100672593-100672613 | 0.02595 |
| 8231882 | chrX:100672615-100672637 | 0.002 |
| 8231884 | chrX:100672640-100672675 | 0.00162857142857 |
| 8231886 | chrX:100672706-100672829 | 0.0997154471545 |
| 8231890 | chrX:100672850-100672871 | 0.005 |
| 8231892 | chrX:100672878-100672960 | 0.37693902439 |
| 8231894 | chrX:100672961-100672963 | 0.649 |
| 8231896 | chrX:100672966-100673031 | 0.269815384615 |
| 8231898 | chrX:100673045-100673078 | 0.336272727273 |
| 8231904 | chrX:100673105-100673129 | 0.561625 |
| 8231908 | chrX:100673137-100673172 | 0.628285714286 |
| 8231910 | chrX:100673180-100673248 | 0.0339705882353 |
| 8231912 | chrX:100673256-100673365 | 0.00911926605505 |
| 8231914 | chrX:100673381-100673404 | 0.0285652173913 |
| 8231916 | chrX:100673420-100673459 | 0.00651282051282 |
| 8231918 | chrX:100673472-100673519 | 0.115723404255 |
| 8231920 | chrX:100673627-100673816 | 0.156026455026 |
| 8231924 | chrX:100673828-100673894 | 0.0700606060606 |
| 8231926 | chrX:100674074-100674113 | 0.0114102564103 |
| 8231928 | chrX:100674125-100674160 | 0.00817142857143 |
| 8231930 | chrX:100674239-100674274 | 0.121914285714 |
| 8231932 | chrX:100674278-100674361 | 0.168096385542 |
| 8231934 | chrX:100674450-100674480 | 0.0153 |
| 8231936 | chrX:100674579-100674608 | 0.00451724137931 |
| 8231938 | chrX:100674716-100674750 | 0.0809705882353 |
| 8231940 | chrX:100675114-100675169 | 0.00981818181818 |
| 8231942 | chrX:100675274-100675312 | 0.012 |
| 8231944 | chrX:100675450-100675533 | 0.0708915662651 |
| 8231946 | chrX:100675542-100675579 | 0.150081081081 |
| 8231950 | chrX:100675740-100675761 | 0.00514285714286 |
| 8231952 | chrX:100675770-100675915 | 0.0276551724138 |
| 8231958 | chrX:100675918-100675953 | 0.4648 |
| 8231960 | chrX:100675961-100676025 | 0.20571875 |
| 8231964 | chrX:100676036-100676073 | 0.00567567567568 |
| 8231966 | chrX:100676131-100676251 | 0.309708333333 |
| 8231970 | chrX:100676273-100676454 | 0.200966850829 |
| 8231978 | chrX:100676468-100676510 | 0.00914285714286 |
| 8231982 | chrX:100676516-100676591 | 0.08064 |
| 8231986 | chrX:100676595-100676706 | 0.0452972972973 |
| 8231990 | chrX:100676711-100676750 | 0.0158974358974 |
| 8231992 | chrX:100676775-100676937 | 0.191388888889 |
| 8231994 | chrX:100676980-100677007 | 0.160777777778 |
| 8231998 | chrX:100677084-100677119 | 0.0521428571429 |
| 8232000 | chrX:100677136-100677190 | 0.0307777777778 |
| 8232002 | chrX:100677200-100677286 | 0.108697674419 |
| 8232004 | chrX:100677308-100677371 | 0.122444444444 |
| 8232008 | chrX:100677421-100677467 | 0.0015 |
| 8232010 | chrX:100677471-100677620 | 0.0230402684564 |
| 8232026 | chrX:100677724-100677865 | 0.331638297872 |
| 8232030 | chrX:100677887-100677908 | 0.752 |
| 8232032 | chrX:100677977-100677997 | 0.74325 |
| 8232036 | chrX:100678045-100678079 | 0.317852941176 |
| 8232038 | chrX:100678214-100678240 | 0.773115384615 |
| 8232040 | chrX:100678259-100678316 | 0.0145614035088 |
| 8232046 | chrX:100678501-100678514 | 0.00615384615385 |
| 8232048 | chrX:100678516-100678554 | 0.0381052631579 |
Network View
Disease Annotation
| Molecule | Disease | Data Source |
|---|---|---|
| Xist | hematologic cancer | LncRNADisease Database |
| Xist | amyotrophic lateral sclerosis | eDGAR Database |
| Xist | tremor, hereditary essential | eDGAR Database |