SmProt

Specific Information of Small Protein : SPROHSA316611

General Information

Small Protein ID	SPROHSA316611
Organism	Human (Homo sapiens)
Small Protein Sequence	LFQEHQFEALGLLILLRLWRVARIINGIIISVKTRSERQLLRLKQMNVQLAAKIQHLEFSCSEKEQEIERLNKLLRQHGLLGEVN*
RNA Sequence	CTGTTCCAGGAGCACCAGTTTGAGGCTCTGGGCCTGCTGATTCTGCTCCGGCTGTGGCGGGTGGCCCGGATCATCAATGGGATTATCATCTCAGTTAAGACACGTTCAGAACGGCAACTCTTAAGGTTAAAACAGATGAATGTACAATTGGCCGCCAAGATTCAACACCTTGAGTTCAGCTGCTCTGAGAAGGAACAAGAAATTGAAAGACTTAACAAACTATTGCGACAGCATGGACTTCTTGGTGAAGTGAACTAG
Protein Length	85
Start Codon	CTG
Location	chr12:110649409-110651295:-
Blocks	110649409-110649475,110650167-110650280,110651216-110651295
Mean PhyloCSF	2.7861666639
Data Source	Ribosome profiling;
Related Genes	ENSG00000204852; TCTN1; ENSG00000122986; HVCN1;
Mass (Da)	mono. 10006.6; avg. 10012.7

Ribosome profiling

Ribo-seq ID	Ensembl Gene ID	Ensembl Transcript ID	Symbol	Gene Type	TIS Type	Ribo P value	TIS P value	Start On Trans	Stop On Trans	In-frame Count	Ribo-seq RPKM
GSE81802_alt	ENSG00000122986.13	ENST00000356742.9	HVCN1	Protein_coding	Truncated	0.002539	0.026545	1318	1576	NA	NA
GSE81802_alt	ENSG00000122986.13	ENST00000620084.4	HVCN1	Protein_coding	Truncated	0.002539	0.041309	586	844	NA	NA
GSE81802_alt	ENSG00000122986.13	ENST00000439744.6	HVCN1	Protein_coding	Truncated	0.002539	0.041309	680	938	NA	NA
GSE81802_alt	ENSG00000122986.13	ENST00000242607.12	HVCN1	Protein_coding	Truncated	0.002539	0.041309	745	1003	NA	NA

Min Ribo P value	0.002539
Min TIS P value	0.026545

Ribo-seq ID	Cell or Tissue	Phenotype	Ribo-seq Source Details	PMID
GSE81802_alt	CD19+ B cells	WT	GSM2175737	29529302;

Database information

No results

Literature information

No results

Mass Spectrometry Information

No results

Function and Disease

Functional domain prediction

Analysis	Signature Accession	Signature Description	Start location	Stop location	Score	Status of the match	InterPro accession	InterPro description	GO	Pathways
Gene3D	G3DSA:1.20.5.170		28	85	1.3E-34	T
Pfam	PF16799	C-terminal membrane-localisation domain of ion-channel, VCN1	38	84	1.8E-28	T	IPR031844	Voltage-gated hydrogen channel 1, C-terminal membrane-localisation domain		Reactome: R-HSA-1222556\|Reactome: R-HSA-1300642\|Reactome: R-HSA-6798695
Coils	Coil		54	74	-	T
PANTHER	PTHR46480		3	80	2.7E-25	T	IPR031846	Voltage-gated hydrogen channel 1	GO:0005887\|GO:0030171\|GO:1902600	Reactome: R-HSA-1222556\|Reactome: R-HSA-1300642\|Reactome: R-HSA-6798695

Disease	Detected
No results

Related Variants

Variant ID	Consequence to sORF	rsID	Ribo-seq ID
12-110650222-C-G	Non-Synonymous p.M46I	.	SRR5239057

Related Small Proteins with Different TISs

SmProt ID	Small Protein Length	Start Codon	Strand	Blocks
SPROHSA230188	32	ATT	-	110649409-110649475, 110650167-110650200