Detail Information of small proteins related to Human Microbiomes for Family ID: 10
General Information
Family ID10
No. Members2455
Small Protein Length50
Representative AA Seq (detail) MKRIKTIETRDLKKSVKTGGCGECQTSCQSACKTSCGVANQQCEKCMSEK
Representative DNA Seq (detail) ATGAAGAGAATTAAAACTATCGAAACTCGTGACCTCAAGAAGAGCGTTAAGACAGGCGGTTGCGGCGAGTGCCAGACTTCATGTCAGTCAGCGTGTAAGACATCTTGCGGCGTTGCTAACCAGCAGTGCGAAAAGTGCATGAGCGAGAAATAA
Example of a Refseq homologWP_042682158.1
Associated HGT genesHTH_MerR-trunc, Tn916-Xis, SR_IS607_transposase_like, INT_C_like_4, Y1_Tnp, PRK09871, INT_ICEBs1_C_like, Recombinase, INT_P4_C, recomb_XerD, PRK09870, SR_TndX_transposase, Phage_int_SAM_4, Zn_ribbon_recom, INT_StrepXerD_C_like, INT_RitA_C_like, SR_Res_par, INT_Lambda_C, RecA-like_NTPases, PHA02517, HTH_28, recomb_XerC, RAYT, DNA_BRE_C, XerC, recA, INT_C_like_2, xerC, Phage_int_SAM_1, Transposase_20, T_den_put_tspse, INT_RitC_C_like, SR_ResInv, INT_C_like_5, int, MULE, INT_C_like_3, RecA, PRK09409, HTH_Hin_like, DDE_Tnp_IS240, XerD, INT_Cre_C, xerD, xerS, INT_XerDC_C, DEDD_Tnp_IS110, INT_FimBE_like, Integrase_DNA, PinE, INT_Rci_Hp1_C, INT_C_like_6, INT_IntI_C, INT_C_like_1, PRK15417, Phage_integrase, integrase_gron, INT_RitB_C_like, Ser_Recombinase, Phage_int_SAM_3, PDDEXK_2, INTN1_C_like, HTH_Tnp_1
Number of non bacterial 1
Non bacterial classification_numbe of members that were classified to itcellular organisms_3
RNA code p-value assigned to family5.73E-11
number of species192
SpeciesBacteroides pectinophilus CAG:437_1, Roseburia sp. CAG:380_2, Streptococcus sp. 263_SSPC_1, Lachnoanaerobaculum saburreum_33, Butyrivibrio sp. MC2013_1, uncultured Oscillibacter sp._1, Clostridium sp. CAG:299_2, Eubacterium sp. CAG:581_3, Streptococcus timonensis_1, Clostridium sp. CAG:226_3, Peptoanaerobacter stomatis_2, Catabacter sp. UBA7707_2, Clostridiales bacterium UBA1246_1, Peptostreptococcaceae bacterium OBRC8_1, Ruminococcaceae bacterium UBA5904_6, Ruminococcaceae bacterium UBA1821_1, Christensenellaceae bacterium Phil1_3, Ruminococcus sp. UBA4350_3, Eubacterium ventriosum_2, Eubacterium sp. CAG:86_1, Clostridium hathewayi CAG:224_1, Ruminococcaceae bacterium UBA2089_7, Clostridiales bacterium 59_14_1, Ruminococcus bromii_15, Lachnospiraceae bacterium C7_1, Subdoligranulum variabile_3, Firmicutes bacterium CAG:83_51, Faecalibacterium sp. CAG:74_58_120_4, Clostridium sp. CAG:7_11, Ruminococcus sp. Phil11_2, Coprococcus sp. ART55/1_1, Lachnospiraceae bacterium UBA6987_25, Clostridium phoceensis_8, Firmicutes bacterium CAG:124_2, Lactobacillus iners_3, Mogibacterium pumilum_181, Clostridium sp. ATCC BAA-442_1, Oscillibacter sp. 57_20_3, Actinomyces oris_1, Roseburia inulinivorans_1, Oscillibacter sp. CAG:241_1, Anaerotruncus rubiinfantis_5, Coprococcus sp. CAG:131-related_45_246_2, Peptostreptococcaceae bacterium CM2_2, Firmicutes bacterium CAG:129_59_24_1, Peptoniphilus sp. HMSC075B08_1, Eubacterium sp. CAG:180_7, [Bacteroides] pectinophilus_2, Firmicutes bacterium CAG:24_1, Ruminococcus sp. CAG:177_1, Campylobacter concisus_2, Lachnoclostridium phytofermentans_1, Parasutterella excrementihominis CAG:233_1, Firmicutes bacterium CAG:24053_14_9, Dialister sp. UBA734_1, Flavonifractor sp. An100_1, Lachnoanaerobaculum sp. ICM7_52, Neisseria sp. oral taxon 014_1, Peptoniphilus sp. KHD2_1, Holdemanella biformis_4, [Clostridium] symbiosum_1, Prevotella shahii_1, Streptococcus sp. 400_SSPC_1, Pseudoflavonifractor sp. Marseille-P3106_1, Lactonifactor longoviformis_12, Atopobium sp. BV3Ac4_1, Oribacterium sp. oral taxon 108_1, Clostridium sp. CAG:217_53_7_1, Eubacterium siraeum CAG:80_5, Anaerococcus provencensis_4, Intestinimonas butyriciproducens_1, Bacteroides sp. AR29_1, Neglecta timonensis_2, Veillonella sp. HPA0037_1, Phascolarctobacterium succinatutens_1, Actinomyces sp. ICM47_1, Ruminococcus albus_1, Clostridium sp. CAG:138_4, uncultured Faecalibacterium sp._99, Neisseria mucosa_1, Clostridiales bacterium_5, Massilioclostridium coli_1, Anaeromassilibacillus sp. An172_1, Prevotella histicola_1, Anaerococcus sp. Marseille-P3625_1, Oribacterium asaccharolyticum_2, Clostridium sp. CAG:75_23, Eubacterium sp. CAG:841_1, Oribacterium sinus_190, [Eubacterium] rectale_1, uncultured Coprococcus sp._5, Lachnospiraceae bacterium TF01-11_1, Firmicutes bacterium CAG:176_63_11_1, Clostridiales bacterium UBA7273_1, Faecalitalea sp. UBA637_10, Gemmiger sp. An120_1, Faecalibacterium sp. CAG:82_32, [Clostridium] saccharolyticum_1, Clostridium sp. CAG:58_7, Clostridium sp. CAG:277_1, Lachnospiraceae bacterium oral taxon 082_49, Ruminococcaceae bacterium UBA1213_1, Peptoniphilus sp. EL1_1, Ruminococcaceae bacterium UBA6842_1, Ruminococcus sp. CAG:108_16, Rothia sp. HMSC061D12_1, Clostridium sp. AT4_7, Coprococcus sp. CAG:131_1, Firmicutes bacterium CAG:534_3, Roseburia hominis_1, Clostridiales bacterium 52_15_101, Coprococcus eutactus CAG:665_2, Paenisporosarcina quisquiliarum_1, Lachnospiraceae bacterium UBA7093_8, Coprococcus comes_2, Lachnoanaerobaculum sp. OBRC5-5_7, Streptococcus sp. HMSC034E03_1, Ruminococcaceae bacterium D5_2, Dialister invisus_2, Coprococcus eutactus_27, Eubacterium sp. CAG:202_12, Ruminococcaceae bacterium UBA6434_1, Eubacterium sp. CAG:115_1, Parvimonas sp. oral taxon 110_1, Clostridiales bacterium 42_27_24, Firmicutes bacterium UBA5911_1, Subdoligranulum sp. 60_17_84, Clostridium sp. 42_12_3, Fenollaria massiliensis_1, Bacteroidetes bacterium UBA4416_1, Faecalibacterium prausnitzii_344, Firmicutes bacterium CAG:94_2, Prevotella sp. HJM029_1, [Clostridium] sporosphaeroides_3, Bacteroides caccae CAG:21_1, Clostridiales bacterium 41_21_two_genomes_2, Clostridium sp. CAG:964_1, Ruminococcaceae bacterium UBA4650_2, Lachnoanaerobaculum sp. MSX33_5, Ruminococcaceae bacterium UBA7067_3, Gemmiger formicilis_50, Roseburia intestinalis_2, Johnsonella ignava_5, Clostridiales bacterium VE202-28_1, [Eubacterium] yurii_5, Anaerococcus sp. UBA2626_14, Clostridium sp. CAG:1013_1, Stomatobaculum longum_351, Niameybacter massiliensis_1, Clostridiales bacterium UBA7568_1, butyrate-producing bacterium SS3/4_2, Catabacter sp. UBA7597_1, Lachnospiraceae bacterium ND2006_1, Ruminococcaceae bacterium UBA3315_1, Clostridium sp. CAG:217_6, Catonella morbi_1, Selenomonas bovis_1, Peptoniphilus sp. BV3C26_2, Peptoniphilus rhinitidis_4, Ruminococcus sp. UBA1409_2, Anaerococcus tetradius_1, Clostridiales bacterium 43-6_1, Catabacter sp. UBA1259_1, Acidimicrobiaceae bacterium TMED77_1, Clostridium botulinum_1, Clostridium sp. 28_17_1, Lachnospiraceae bacterium oral taxon 500_42, Oscillibacter sp. 1-3_1, Clostridium sp. L2-50_11, Clostridium sp. CAG:253_3, Oscillibacter sp. ER4_19, Faecalibacterium sp. UBA2087_12, Firmicutes bacterium CAG:114_5, [Eubacterium] siraeum_77, Firmicutes bacterium CAG:272_52_7_1, Selenomonas sp. CM52_25, Ruminococcus sp. 37_24_17, Clostridiales bacterium 41_12_two_minus_1, Ruminococcus sp. A254.MGS-108_6, Oribacterium sp. oral taxon 078_3, Ruminococcus bicirculans_1, Mogibacterium sp. CM50_1, Lachnospira sp. UBA2821_2, Parvimonas micra_1, Lachnospiraceae bacterium UBA3772_1, Alistipes sp. An66_1, [Clostridium] clostridioforme_2, Lachnospiraceae bacterium 6_1_37FAA_1, Clostridium sp. CAG:12237_41_2, Unclassified_13, Hungatella hathewayi_1, Fusobacterium periodonticum_1, Selenomonas sputigena_13

Sample Origin
Body SitesNo. SamplesFraction
Mouth2030.918552036
Skin110.379310345
Vagina50.113636364
Gut2170.87854251
Number of homologs from non-human metagenomesNumber of different types of non-human environmentsNon human environments in which homologs exist_number of homologs
253Mammals_23, Wastewater_1, Bioreactor_1

Function prediction
% of family members that are predicted to have a transmembrane domain (TMHMM)0
Is family classified as Transmembrane (TMHMM)0
% of family members that are predicted to have a signal peptide in gram+ (SignalP_v5.0)0.991038697
Is family predicted to be secreted in gram+ (SignalP_v5.0)1
% of family members that are predicted to have a signal peptide in gram- (SignalP_v5.0)0.706720978
Is family predicted to be secreted in gram- (SignalP_v5.0)0
Number of members the are transmembrane (Phobius)0
Fraction of members that are transmembrane (Phobius)0
Number of members that are secreted (Phobius)0
Fraction of members that are secreted (Phobius)0
Number of significant complete CDD hits that were assigned to family representative sequence2
PSSMs assigned274891, 315759
Domains assignedsix_Cys_in_45, SCIFF

References
PubMed ID31402174
TitleLarge-Scale Analyses of Human Microbiomes Reveal Thousands of Small, Novel Genes
AuthorsHila Sberro, Brayon J. Fremin, Soumaya Zlitni, Fredrik Edfors, Nicholas Greenfield, Michael P. Snyder, Georgios A. Pavlopoulos, Nikos C. Kyrpides, and Ami S. Bhatt
JournalCell 178, 1–15, August 22, 2019