Specific Information of Small Protein : SPROHSA145930
General Information
Small Protein IDSPROHSA145930
Organismhuman (Homo sapiens)
Small Protein SequenceMTDSSARTEALSILYPAVRYWRRKTFNKYLLNDEYALGVAK*
RNA SequenceATGACAGACagctctgcaagaacggaggccctgtctattttgtacccagctgtacggtactggcgccgaaagacgttcaataaatacttattgaatgacgaatACGCGTTAGGAGTTGCAAAATAA
Protein Length41
Start CodonATG
Locationchr2:174396175-174397343:+
Blocks174396175-174396293,174397335-174397343
Mean PhyloCSF-7.10054760509
Data SourceRibosome profiling;
Related GenesENSG00000144306; SCRN3; NONHSAG077962;
Ribosome profiling
RiboIDGeneIDTransIDSymbolGeneTypeTISTypeRiboPvalueTISPvalueStartOnTransStopOnTrans
SRR5047772ENSG00000144306.14ENST00000488349.1SCRN3protein_codingNovel0.035269None381507
GSE94613_2ENSG00000144306.14ENST00000488349.1SCRN3protein_codingNovel0.003483None381507
GSE94613_2_altENSG00000144306.14ENST00000488349.1SCRN3protein_codingNovel0.003483None381507
Min Ribo Pvalue0.003483
Min TIS PvalueNone
RiboIDCellORTissuePhenotypeRiboSourcePMID
GSE94613_2MOLM13acute myeloid leukemiaGSM248105329186125;
GSE94613_2_altMOLM13acute myeloid leukemiaGSM248105329186125;
SRR5047772iPSC-differentiated dopamine neuronsParkinson DiseaseNANA;

Database information
No results
Literature information
No results
Mass Spectrometry Information
No results
Function and Disease
Functional domain prediction Funtion   
AnalysisSignature AccessionSignature DescriptionStart locationStop locationScoreStatus of the matchInterPro accessionInterPro descriptionGOPathways
No results
DiseaseDetected
acute myeloid leukemiaPredictedByRibo
Related Variants
VarIDConsequence To sORFrsIDRiboID
2-174396181-A-TSynonymous p.T2Trs79355383SRR5239057;SRR5239058
Related Small Proteins with Different TISs
IDSmall Protein LengthStart CodonStrandBlocks
No results
References
PMID29186125
TitlePromoter-bound METTL3 maintains myeloid leukaemia by m 6 A-dependent translation control
JournalNature.2017 Dec 7;552(7683):126-131.doi: 10.1038/nature24678.Epub 2017 Nov 27.
AuthorsIsaia Barbieri,Konstantinos Tzelepis,Luca Pandolfini,Junwei Shi,Gonzalo Millán-Zambrano,Samuel C Robson,Demetrios Aspris,Valentina Migliori,Andrew J Bannister,Namshik Han,Etienne De Braekeleer,Hannes Ponstingl,Alan Hendrick,Christopher R Vakoc,George S Vassiliou,Tony Kouzarides