NyuWa Genome Resource

Introduction

NyuWa, or NüWa, is the mother goddess who was the creator of the human population in Chinese mythology. Based on large number of high depth whole genome sequencing (WGS) of Chinese individuals, we generated the NyuWa Genome Resource series. The resouce mainly contains variant databases and haplotype reference panel webservers.

NyuWa Global 10K T2T Variant Database^New Go »

The NyuWa Global 10K T2T resource is based on high depth (mean 31.7X) whole genome sequencing (WGS) of 10,457 individuals. The dataset intergrates individuals from 1KGP, HGDP, and SGDP datasets, and includes over 100 populations from all over the world. The database included functions of variant search, annotation and imputation services.

NyuWa Chinese Population Variant Database Go »

NyuWa Chinese Population Variant Database(NCVD) archives 71 million (M) SNPs and 8 M indels from the NyuWa dataset of 2,999 Chinese individuals from 23 out of 34 administrative divisions in China, and comprehensively annotates the variants on allele frequency in our Chinese dataset and external datasets (including 1KGP3, gnomAD v3.0). Besides, Variant quality metrics, genome region annotation, nonsynonymous impact, loss of function predict, clinical annotation, pharmacogenomics annotation are also collected and presented.

NyuWa reference panel server Go »

NyuWa haplotype reference panel was constructed using 19,256,267 SNPs and short indels with minor allele count >= 5 (MAC5, approximately MAF > 0.1%) in 2,902 independent samples, in which 77.2k (0.4%) were novel variants in NyuWa dataset. Compared with 4 other public available reference panels including 1KGP3, Haplotype Reference Consortium release 1.1 (HRC.r1.1), GAsP and TOPMed r2, NyuWa reference panel had 3.25M specific variants not included in other panels.