Alias
-
Class
mRNA
Ensembl id
ENSG00000154277
Organism
Homo sapiens
Description
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (Probable). This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (PubMed:9774100, PubMed:8639624, PubMed:12408865, PubMed:23359680). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (PubMed:12408865).
| Interaction ID | Interact With | Tissue or Cell line | Pubmed | Data source |
|---|
| Disease Name | Data Source | PubMed |
|---|---|---|
| neurodegeneration with optic atrophy, childhood-onset | eDGAR Database | |
| parkinson disease | eDGAR Database |