Alias
-
Class
protein
UniProt id
Organism
Homo sapiens
Description
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 ex
| Interaction ID | Interact With | Tissue or Cell line | Pubmed | Data source |
|---|
| Disease Name | Data Source | PubMed |
|---|---|---|
| adrenal gland cancer | MNDR Database | 9052405 |
| adrenocortical carcinoma, hereditary | eDGAR Database | |
| basal cell carcinoma, susceptibility to, 7 | eDGAR Database | |
| breast cancer | eDGAR Database | |
| breast cancer | MNDR Database | 9052405 |
| colon carcinoma | MNDR Database | 9052405 |
| colorectal cancer | eDGAR Database | |
| colorectal cancer | MNDR Database | 9052405 |
| endometrial cancer | MNDR Database | 9052405 |
| esophageal cancer | MNDR Database | 9052405 |
| esophageal carcinoma | MNDR Database | 9052405 |
| Glioblastoma | MNDR Database | 9052405 |
| glioma | eDGAR Database | |
| head and neck squamous cell carcinoma | MNDR Database | 9052405 |
| hepatocellular carcinoma | eDGAR Database | |
| hepatocellular carcinoma | MNDR Database | 9052405 |
| li-fraumeni syndrome | eDGAR Database | |
| lymphoma, non-hodgkin, familial | eDGAR Database | |
| malignant mesothelioma | MNDR Database | 9052405 |
| nasopharyngeal carcinoma | eDGAR Database | |
| osteogenic sarcoma | eDGAR Database | |
| Ovarian Neoplasms | MNDR Database | 9052405 |
| pancreatic cancer | eDGAR Database | |
| pancreatic cancer | MNDR Database | 9052405 |
| papilloma of choroid plexus | eDGAR Database | |
| Prostatic Neoplasms | MNDR Database | 9052405 |
| renal cell carcinoma | MNDR Database | 9052405 |
| stomach cancer | MNDR Database | 9052405 |
| Uterine Cervical Neoplasms | MNDR Database | 9052405 |