Interaction Profile
Interaction ID
ncRI-51487708
Interaction Molecules
LINC00511 -- EGR1
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
Literature mining
Tags
Organism
Homo sapiens
Tissue or Cell Type
-
Experiment
RIP
Description
This interaction was independently validated using RNA immunoprecipitation (RIP) assays, which enriched SLNCR (~4- to 10-fold) in RNAs immunoprecipitating with EGR1
Molecule Profile
Alias
EGR1
Class
protein
UniProt id
Description
Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.
Reference Information
| Pubmed ID | 31116991 | Journal | Cell reports |
|---|---|---|---|
| Title | The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21. | ||
| Author | Karyn Schmidt, Johanna S Carroll, Elaine Yee, Dolly D Thomas, Leon Wert-Lamas, Steven C Neier, Gloria Sheynkman, Justin Ritz, Carl D Novina | ||
Network View
Disease Annotation
| Molecule | Disease | Data Source |
|---|---|---|
| LINC00511 | acquired immunodeficiency syndrome | MNDR Database |
| LINC00511 | Alzheimer's disease | MNDR Database |
| LINC00511 | breast cancer | LncRNADisease Database |
| LINC00511 | breast cancer | MNDR Database |
| LINC00511 | cancer | MNDR Database |
| LINC00511 | Carcinoma, Non-Small-Cell Lung | MNDR Database |
| LINC00511 | colorectal cancer | MNDR Database |
| LINC00511 | hepatocellular carcinoma | MNDR Database |
| LINC00511 | Huntington's disease | MNDR Database |
| LINC00511 | lung adenocarcinoma | LncRNADisease Database |
| LINC00511 | lung adenocarcinoma | MNDR Database |
| LINC00511 | lung cancer | MNDR Database |
| LINC00511 | lymphoma | MNDR Database |
| LINC00511 | melanoma | MNDR Database |
| LINC00511 | osteosarcoma | MNDR Database |
| LINC00511 | Ovarian Neoplasms | MNDR Database |
| LINC00511 | pancreatic cancer | MNDR Database |
| LINC00511 | pancreatic ductal adenocarcinoma | MNDR Database |
| LINC00511 | Prostatic Neoplasms | MNDR Database |