Interaction: ncRI-50167674

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Interaction Profile

Interaction ID

ncRI-50167674

Interaction Molecules

hsa-miR-573 -- CNOT4

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

miRanda with Ago CLIP data

Tags

Organism

Homo sapiens

Tissue or Cell Type

Prefrontal Cortex (PFC), Gestation Week 19.5

Experiment

AGO HITS-CLIP; Conserved miRNAs target sites predicted by TargetScan and miRanda overlap with the AGO CLIP dataset

Description

interactions between miRNA and mRNA; GEOid: GSE107468

Molecule Profile

hsa-miR-573

⇔

CNOT4

Alias

hsa-miR-573

Class

miRNA

miRBase id

MI0003580

Description

Homo sapiens miR-573 stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSG00000080802

Description

Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292). Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038). Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292).

Reference Information
Pubmed ID 30455455 Journal Nature neuroscience
Title Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development.
Author Nowakowski TJ, Rani N, Golkaram M, Zhou HR, Alvarado B, Huch K, West JA, Leyrat A, Pollen AA, Kriegstein AR, Petzold LR, Kosik KS
Network View
Disease Annotation
Molecule Disease Data Source
hsa-miR-573 Barrett's adenocarcinoma MNDR Database
hsa-miR-573 bone disease MNDR Database
hsa-miR-573 brain disease MNDR Database
hsa-miR-573 breast cancer MNDR Database
hsa-miR-573 Breast Neoplasms MNDR Database
hsa-miR-573 cancer MNDR Database
hsa-miR-573 carcinoma MNDR Database
hsa-miR-573 Cerebral Hemorrhage, Traumatic MNDR Database
hsa-miR-573 colorectal cancer MNDR Database
hsa-miR-573 diabetes mellitus MNDR Database
hsa-miR-573 eye disease MNDR Database
hsa-miR-573 Glioblastoma MNDR Database
hsa-miR-573 head and neck cancer MNDR Database
hsa-miR-573 heart disease MNDR Database
hsa-miR-573 hepatocellular carcinoma MNDR Database
hsa-miR-573 Her2-receptor positive breast cancer MNDR Database
hsa-miR-573 hypersensitivity reaction type II disease MNDR Database
hsa-miR-573 Intracranial Hemorrhage, Hypertensive MNDR Database
hsa-miR-573 leukemia MNDR Database
hsa-miR-573 lung adenocarcinoma MNDR Database
hsa-miR-573 lung cancer MNDR Database
hsa-miR-573 lung disease MNDR Database
hsa-miR-573 malignant glioma MNDR Database
hsa-miR-573 melanoma MNDR Database
hsa-miR-573 myopathy MNDR Database
hsa-miR-573 neurodegenerative disease MNDR Database
hsa-miR-573 pancreatic cancer MNDR Database
hsa-miR-573 pancreatic ductal adenocarcinoma MNDR Database
hsa-miR-573 progesterone-receptor negative breast cancer MNDR Database
hsa-miR-573 progesterone-receptor positive breast cancer MNDR Database
hsa-miR-573 Prostatic Neoplasms MNDR Database
hsa-miR-573 rectum cancer MNDR Database
hsa-miR-573 skin disease MNDR Database
hsa-miR-573 stomach cancer MNDR Database
hsa-miR-573 stomach carcinoma MNDR Database
hsa-miR-573 vascular disease MNDR Database