Interaction Profile
Interaction ID
ncRI-50158355
Interaction Molecules
Gm11607 -- DAZL
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Mus musculus
Tissue or Cell Type
testes
Experiment
CLIP-Seq
Description
Dazl maintains proliferating germ cells through a network of polyA-proximal mRNA interactions [Adult HITS-CLIP]; GEO id: GSE108181.
Molecule Profile
Alias
-
Class
protein
UniProt id
Description
RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts.
Reference Information
| Pubmed ID | 30380414 | Journal | Cell reports |
|---|---|---|---|
| Title | DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions. | ||
| Author | Leah L Zagore, Thomas J Sweet, Molly M Hannigan, Sebastien M Weyn-Vanhentenryck, Raul Jobava, Maria Hatzoglou, Chaolin Zhang, Donny D Licatalosi | ||
Network View