Interaction: ncRI-50137967

Interaction Profile

Interaction ID

ncRI-50137967

Interaction Molecules

Gm16151 -- DAZL

Interaction Level

RNA-Protein

Interaction Class

binding

Data Source

High-throughput data

Tags

Organism

Mus musculus

Tissue or Cell Type

GC1-spg cells

Experiment

CLIP-Seq

Description

Dazl regulates germ cell survival through a network of polA-proximal mRNA interactions [GC1-spg cells (parental line) iCLIP]; GEO id: GSE120098.

Molecule Profile

Alias

-

Class

lncRNA

NONCODE id

NONMMUG000448

Description

Antisense

Alias

-

Class

protein

UniProt id

Q64368

Description

RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts.

Reference Information
Pubmed ID 30380414 Journal Cell reports
Title DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions.
Author Leah L Zagore, Thomas J Sweet, Molly M Hannigan, Sebastien M Weyn-Vanhentenryck, Raul Jobava, Maria Hatzoglou, Chaolin Zhang, Donny D Licatalosi
Network View