Interaction ID
ncRI-50119062
Interaction Molecules
4632404H12Rik -- AGO2
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Mus musculus
Tissue or Cell Type
interscapular brown adipose tissue
Experiment
CLIP-Seq
Description
Ago-CLIP sequencing mRNA sequencing analysis for two types of wildtype mouse adipose tissue and miRNA sequencing analysis for six types of wildtype mouse adipose tissue; BAT_10t; GEO id: GSE142677
Alias
4632404H12Rik
Class
lncRNA
Ensembl id
ENSMUSG00000042579
Description
RIKEN cDNA 4632404H12 gene
Alias
AGO
Class
protein
UniProt id
Description
Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA
| Pubmed ID | 33832988 | Journal | Genes & development |
|---|---|---|---|
| Title | AGO HITS-CLIP reveals distinct miRNA regulation of white and brown adipose tissue identity. | ||
| Author | Sean O'Connor, Elisabeth A Murphy, Sarah K Szwed, Matt Kanke, François Marchildon, Praveen Sethupathy, Robert B Darnell, Paul Cohen | ||