Interaction ID
ncRI-50117214
Interaction Molecules
1700026D11Rik -- AGO2
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Mus musculus
Tissue or Cell Type
CD4+ T cells
Experiment
CLIP-Seq
Description
AGO HITS-CLIP librarires were generated from wildtype and miR-29 deficient CD4 T cells under various stimulation conditions after crosslinking immunoprecipiation of AGO2; Th2_B6_6hrStim; GEO id: GSE130655
Alias
AGO
Class
protein
UniProt id
Description
Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA
| Pubmed ID | 31433990 | Journal | Cell reports |
|---|---|---|---|
| Title | miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival. | ||
| Author | John D Gagnon, Robin Kageyama, Hesham M Shehata, Marlys S Fassett, Darryl J Mar, Eric J Wigton, Kristina Johansson, Adam J Litterman, Pamela Odorizzi, Dimitre Simeonov, Brian J Laidlaw, Marisella Panduro, Sana Patel, Lukas T Jeker, Margaret E Feeney, Michael T McManus, Alexander Marson, Mehrdad Matloubian, Shomyseh Sanjabi, K Mark Ansel | ||