Interaction ID
ncRI-50036185
Interaction Molecules
RP11-34P13.13 -- SNRPA
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Homo sapiens
Tissue or Cell Type
HEK293T
Experiment
eCLIP
Description
binding derived from CLIP-seq dataset(GSE117290)
Alias
SNRPA
Class
protein
UniProt id
Description
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNA
| Pubmed ID | 32807991 | Journal | Nature structural & molecular biology |
|---|---|---|---|
| Title | Large-scale tethered function assays identify factors that regulate mRNA stability and translation. | ||
| Author | En-Ching Luo, Jason L Nathanson, Frederick E Tan, Joshua L Schwartz, Jonathan C Schmok, Archana Shankar, Sebastian Markmiller, Brian A Yee, Shashank Sathe, Gabriel A Pratt, Duy B Scaletta, Yuanchi Ha, David E Hill, Stefan Aigner, Gene W Yeo | ||
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 10012548 | chrX:13397350-13397400 | 0.802960 |
| Molecule | Disease | Data Source |
|---|---|---|
| RP11-34P13.13 | Alzheimer's disease | MNDR Database |
| RP11-34P13.13 | breast cancer | MNDR Database |
| RP11-34P13.13 | cancer | MNDR Database |
| RP11-34P13.13 | Carcinoma, Non-Small-Cell Lung | MNDR Database |
| RP11-34P13.13 | colorectal cancer | MNDR Database |
| RP11-34P13.13 | hepatocellular carcinoma | MNDR Database |
| RP11-34P13.13 | Huntington's disease | MNDR Database |
| RP11-34P13.13 | lung cancer | MNDR Database |
| RP11-34P13.13 | lymphoma | MNDR Database |
| RP11-34P13.13 | malignant glioma | MNDR Database |
| RP11-34P13.13 | melanoma | MNDR Database |
| RP11-34P13.13 | neuroblastoma | MNDR Database |
| RP11-34P13.13 | Ovarian Neoplasms | MNDR Database |
| RP11-34P13.13 | Prostatic Neoplasms | MNDR Database |
| RP11-34P13.13 | schizophrenia | MNDR Database |
| RP11-34P13.13 | stomach cancer | MNDR Database |
| RP11-34P13.13 | thyroid cancer | MNDR Database |
| RP11-34P13.13 | Urinary Bladder Neoplasms | MNDR Database |
| RP11-34P13.13 | Uterine Cervical Neoplasms | MNDR Database |