Interaction ID

ncRI-41009947

Interaction Molecules

RP11-371A22 -- MET

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

RISE database

Tags

Organism

Homo sapiens

Tissue or Cell Type

HEK293T

Experiment

PARIS

Description

RNA-RNA interaction from RISE database

Alias

-

Class

lncRNA

Ensembl id

ENSG00000283041

Description

pseudogene

Alias

-

Class

mRNA

Ensembl id

ENSG00000105976

Description

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity).