Interaction ID

ncRI-41007116

Interaction Molecules

AC006548 -- IPO11

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

RISE database

Tags

Organism

Homo sapiens

Tissue or Cell Type

HEK293T

Experiment

PARIS

Description

RNA-RNA interaction from RISE database

Alias

-

Class

lncRNA

NONCODE id

-

Description

-

Alias

-

Class

mRNA

Ensembl id

ENSG00000086200

Description

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).