Interaction ID

ncRI-40999454

Interaction Molecules

Gm22507 -- Ipo7

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

RISE database

Tags

Organism

Mus musculus

Tissue or Cell Type

mES

Experiment

PARIS

Description

RNA-RNA interaction from RISE database

Alias

-

Class

snRNA

Ensembl id

ENSMUSG00000064707

Description

snRNA

Alias

-

Class

mRNA

Ensembl id

ENSMUSG00000066232

Description

Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation (By similarity). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones.