Interaction ID
ncRI-40969320
Interaction Molecules
hsa-miR-1275 -- LRH-1
Interaction Level
RNA-RNA
Interaction Class
regulatory
Data Source
Literature mining
Tags
Organism
Homo sapiens
Tissue or Cell Type
HEK293
Experiment
Dual luciferase reporter assays
Description
LRH-1 is a direct functional target of miR-1275 in pGCs
Alias
-
Class
mRNA
UniProt id
Description
Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha- hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38 (By similarity).
| Pubmed ID | 29378329 | Journal | Biochimica et biophysica acta. Gene regulatory mechanisms |
|---|---|---|---|
| Title | miR-1275 controls granulosa cell apoptosis and estradiol synthesis by impairing LRH-1/CYP19A1 axis. | ||
| Author | Liu J, Li X, Yao Y, Li Q, Pan Z, Li Q | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-1275 | acute myeloid leukemia | MNDR Database |
| hsa-miR-1275 | adenoma | MNDR Database |
| hsa-miR-1275 | Alzheimer's disease | MNDR Database |
| hsa-miR-1275 | amyotrophic lateral sclerosis | MNDR Database |
| hsa-miR-1275 | breast cancer | MNDR Database |
| hsa-miR-1275 | Breast Neoplasms | MNDR Database |
| hsa-miR-1275 | cholangiocarcinoma | MNDR Database |
| hsa-miR-1275 | colorectal cancer | MNDR Database |
| hsa-miR-1275 | head and neck cancer | MNDR Database |
| hsa-miR-1275 | hepatocellular carcinoma | MNDR Database |
| hsa-miR-1275 | Her2-receptor positive breast cancer | MNDR Database |
| hsa-miR-1275 | Hodgkin's lymphoma | MNDR Database |
| hsa-miR-1275 | intracranial aneurysm | MNDR Database |
| hsa-miR-1275 | intrahepatic cholangiocarcinoma | MNDR Database |
| hsa-miR-1275 | Liver Neoplasms | MNDR Database |
| hsa-miR-1275 | lung adenocarcinoma | MNDR Database |
| hsa-miR-1275 | lung cancer | MNDR Database |
| hsa-miR-1275 | malignant glioma | MNDR Database |
| hsa-miR-1275 | multiple sclerosis | MNDR Database |
| hsa-miR-1275 | nasopharynx carcinoma | MNDR Database |
| hsa-miR-1275 | nephroblastoma | MNDR Database |
| hsa-miR-1275 | oral squamous cell carcinoma | MNDR Database |
| hsa-miR-1275 | Ovarian Neoplasms | MNDR Database |
| hsa-miR-1275 | pancreatic adenocarcinoma | MNDR Database |
| hsa-miR-1275 | pancreatic cancer | MNDR Database |
| hsa-miR-1275 | polycystic ovary syndrome | MNDR Database |
| hsa-miR-1275 | Precursor Cell Lymphoblastic Leukemia-Lymphoma | MNDR Database |
| hsa-miR-1275 | progesterone-receptor negative breast cancer | MNDR Database |
| hsa-miR-1275 | progesterone-receptor positive breast cancer | MNDR Database |
| hsa-miR-1275 | progressive supranuclear palsy | MNDR Database |
| hsa-miR-1275 | Pseudorabies | MNDR Database |
| hsa-miR-1275 | Stroke, Lacunar | MNDR Database |
| hsa-miR-1275 | Subarachnoid Hemorrhage, Traumatic | MNDR Database |
| hsa-miR-1275 | thyroid carcinoma | MNDR Database |